Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Hidenori Mikamiyama"'
Publikováno v:
Chemistry Letters; Jun2024, Vol. 53 Issue 6, p1-4, 4p
Autor:
Yoshifumi Kusumoto, Kyohei Hayashi, Soichiro Sato, Toru Yamada, Iori Kozono, Zenzaburo Nakata, Naoya Asada, Shungo Mitsuki, Ayahisa Watanabe, Chiaki Wakasa-Morimoto, Kentaro Uemura, Shuhei Arita, Shinobu Miki, Tohru Mizutare, Hidenori Mikamiyama
Publikováno v:
ACS medicinal chemistry letters. 13(10)
Human immunodeficiency virus type-1 (HIV-1) protease is essential for viral propagation, and its inhibitors are key anti-HIV-1 drug candidates. In this study, we discovered a novel HIV-1 protease inhibitor (compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce70e02630fb12dc340f6b4e77a44913
https://pubmed.ncbi.nlm.nih.gov/36262395
https://pubmed.ncbi.nlm.nih.gov/36262395
Autor:
Hidenori Mikamiyama, Taichi Ueda, Douglas R. Cary, Takashi Ono, Shota Uehara, Saki Yamamoto, Kyohei Hayashi, Junichi Nishikawa, Kousuke Mihara, Norito Yoshimura, Taeko Kawai, Shiho Yamamoto, Hiroki Ozasa, Masataka Fumoto
Publikováno v:
ACS Med Chem Lett
[Image: see text] Nicotinamide N-methyltransferase (NNMT), which catalyzes the methylation of nicotinamide, is a cytosolic enzyme that has attracted much attention as a therapeutic target for a variety of diseases. However, despite the considerable i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4bba1edf2b98ca3892e4c8581b120f6
https://pubmed.ncbi.nlm.nih.gov/34267879
https://pubmed.ncbi.nlm.nih.gov/34267879
Autor:
Takao Shishido, Minako Mikamiyama-Iwata, Yoshiyuki Taoda, Tomokazu Yoshinaga, Ryu Yoshida, Naoko Kurihara, Naoyuki Suzuki, Kenji Morimoto, Noriyuki Kurose, Masayoshi Miyagawa, Hidenori Mikamiyama, Makoto Kawai, Kazunari Hattori, Kenji Tomita, Chika Takahashi-Kageyama, Toshiyuki Akiyama, Kenji Matsuo, Kenji Takaya, Akihiko Sato
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(19)
We report the discovery of a novel series of influenza Cap-dependent EndoNuclease (CEN) inhibitors based on the 4-pyridone-carboxylic acid (PYXA) scaffold, which were found from our chelate library. Our SAR research revealed the lipophilic domain to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69232b20f8a66fc4e31959854f6ec6a1
https://pubmed.ncbi.nlm.nih.gov/27568084
https://pubmed.ncbi.nlm.nih.gov/27568084
Publikováno v:
Organic Process Research & Development. 11:1055-1058
HIV-integrase inhibitor S-1360 was synthesized by Claisen-type reaction of 5-(4-fluorobenzyl)-2-furyl methyl ketone with N-protected 1H-1,2,4-triazole-3-carboxylate. The protecting group on the triazole ring is essential for the reaction to proceed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79c64a41f628ca042638b215e7777026
https://doi.org/10.1021/op700116y
https://doi.org/10.1021/op700116y
Publikováno v:
The Journal of Organic Chemistry. 63:9782-9793
The first total synthesis of (−)-macrocarpal C (3) is described. The synthesis features a highly stereoselective coupling reaction of silyldienol ether 6 with biomimetic benzyl cation species (R)- and (S)-B, which were generated from novel hexasubs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebc3d04c6410c44b8de12e9cf84a83ad
https://doi.org/10.1021/jo981413+
https://doi.org/10.1021/jo981413+
Autor:
Kimiya Maeda, Kenji Uenaka, Chuzo Iwata, Yousuke Funakoshi, Hidenori Mikamiyama, Tetsuaki Tanaka
Publikováno v:
Tetrahedron. 52:4257-4268
The stereoselective total syntheses of (+)-aromadendrene ( 5 ) and (−)-alloaromadendrene ( 6 ) were achieved via (+)-(1 S ,2 R ,4 R ,7 S ,11 R )-7- tert -butyldimethylsiloxymethyl-3,3,11-trimethyltricyclo[6.3.0.0 2,4 ]undec-8-en-10-one ( 7 ) as a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a244b7f88e09d58d84275b07ec40b658
https://doi.org/10.1016/0040-4020(96)00086-5
https://doi.org/10.1016/0040-4020(96)00086-5
Autor:
Tetsuaki Tanaka, Chuzo Iwata, Hitoshi Yoshino, Sang-Wong Kim, Kazuo Murakami, Hidenori Mikamiyama, Atsushi Kanda, Osamu Okuda
Publikováno v:
Chemical and Pharmaceutical Bulletin. 43:1407-1411
Formal total synthesis of (±)-aphidicolin (1) was achieved via a Lewis acid-mediated stereoselective spiroannelation reaction as a key step. The bisbenzyl acetal (2) was synthesized from the readily available dimethyl acetal (4). Treatment of 2 with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::465e2eb754a277f3e3a8a85c40423b9c
https://doi.org/10.1248/cpb.43.1407
https://doi.org/10.1248/cpb.43.1407
Autor:
Chuzo Iwata, Hitoshi Yoshino, Hidenori Mikamiyama, Tetsuaki Tanaka, Atsushi Kanda, Kazuo Murakami, Osamu Okuda
Publikováno v:
Tetrahedron Letters. 35:4125-4128
Spiro[5.5]undecane derivatives 6A and 7S were obtained in moderate stereoselectivity by the intramolecular spiroannelation reaction of a bis-acetal 3 promoted by TMSOTf, and the selectivity was reversed by changing the solvent from acetonitrile to TH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a9b856c28d02707a94a3f5a6c75c260
https://doi.org/10.1016/s0040-4039(00)73130-3
https://doi.org/10.1016/s0040-4039(00)73130-3
Autor:
Kenji Uenaka, Yoshiji Takemoto, Kimiya Maeda, Chuzo Iwata, Hidenori Mikamiyama, Yousuke Funakoshi, Naoyoshi Maezaki, Tetsuaki Tanaka
Publikováno v:
Chemical and Pharmaceutical Bulletin. 42:300-305
As a preliminary study for the synthesis of aromadendrane- and alloaromadendrane-type compounds, trans and cis B/C-ring compounds (18 and 22) were synthesized from (+)-(1S, 2R, 4R, 7R)-3, 3, 7-trimethyltricyclo[6.3.0.02, 4]undec-8-en-10-one (3) as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4543b1e0c5f36a734f5d854c9f19d35a
https://doi.org/10.1248/cpb.42.300
https://doi.org/10.1248/cpb.42.300