Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Hidenobu Miyazawa"'
Autor:
Hidenobu Miyazawa, Marteinn T Snaebjornsson, Nicole Prior, Eleni Kafkia, Henrik M Hammarén, Nobuko Tsuchida-Straeten, Kiran R Patil, Martin Beck, Alexander Aulehla
Publikováno v:
eLife, Vol 11 (2022)
How cellular metabolic state impacts cellular programs is a fundamental, unresolved question. Here, we investigated how glycolytic flux impacts embryonic development, using presomitic mesoderm (PSM) patterning as the experimental model. First, we ide
Externí odkaz:
https://doaj.org/article/0c5a0191332144eb9bf2c9c3950be861
Autor:
Hiroaki Semba, Norihiko Takeda, Takayuki Isagawa, Yuki Sugiura, Kurara Honda, Masaki Wake, Hidenobu Miyazawa, Yoshifumi Yamaguchi, Masayuki Miura, Dana M. R. Jenkins, Hyunsung Choi, Jung-whan Kim, Masataka Asagiri, Andrew S. Cowburn, Hajime Abe, Katsura Soma, Katsuhiro Koyama, Manami Katoh, Keimon Sayama, Nobuhito Goda, Randall S. Johnson, Ichiro Manabe, Ryozo Nagai, Issei Komuro
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Migration to the inflamed tissue demands energy production in an increasingly hypoxic environment. Here the authors show that during migration, HIF1α-induced PDK1 uniquely adapts macrophage metabolism to mild hypoxia by promoting glycolysis while pr
Externí odkaz:
https://doaj.org/article/656cb902beff4390965095a7899b983e
Author Reply to Peer Reviews of Glycolytic flux-signaling controls mouse embryo mesoderm development
Autor:
Hidenobu Miyazawa, Marteinn T. Snaebjornsson, Nicole Prior, Eleni Kafkia, Henrik M Hammarén, Nobuko Tsuchida-Straeten, Kiran Raosaheb Patil, Martin Beck, Alexander Aulehla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0ccb19990221545af9bae6e04fee3ef
https://doi.org/10.15252/rc.2022782040
https://doi.org/10.15252/rc.2022782040
Publikováno v:
Developmental Dynamics. 248:931-941
Background The timing of developmental events is tightly regulated along a time axis for normal development. Although the RNA-binding protein Lin28a plays a crucial role in the regulation of developmental timing in Caenorhabditis elegans, how the tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c8cf00e373e8f0d17ddf31504939ac6
https://doi.org/10.1002/dvdy.87
https://doi.org/10.1002/dvdy.87
This protocol is for the in situ hybridization chain reaction (HCR) of intact tails (somites and presomitic mesoderm, PSM) of mouse embryos. This is adapted from the in situ HCR v 3.0 protocol for whole-mount mouse embryos available in the website of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37830e53a67a1b0d97bea407c2709793
https://doi.org/10.17504/protocols.io.7pyhmpw
https://doi.org/10.17504/protocols.io.7pyhmpw
Autor:
Hidenobu Miyazawa, Alexander Aulehla
Publikováno v:
Development
An emerging view emphasizes that metabolism is highly regulated in both time and space. In addition, it is increasingly being recognized that metabolic pathways are tightly connected to specific biological processes such as cell signaling, proliferat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75c20a67e7e6dce23d5a4868c052c7b
https://doi.org/10.1242/dev.131110
https://doi.org/10.1242/dev.131110
Publikováno v:
Genes to cells : devoted to molecularcellular mechanisms. 23(9)
Developing embryos rewire energy metabolism for developmental processes. However, little is known about how metabolic rewiring is coupled with development in a spatiotemporal manner. Here, we show that mammalian embryos display plasticity of glucose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93a83b6d609ff1bc49675a24a1abb2d
https://pubmed.ncbi.nlm.nih.gov/30088697
https://pubmed.ncbi.nlm.nih.gov/30088697
Publikováno v:
Congenital anomalies. 57(5)
Neural tube closure (NTC) is an embryonic process during formation of the mammalian central nervous system. Disruption of the dynamic, sequential events of NTC can cause neural tube defects (NTD) leading to spina bifida and anencephaly in the newborn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de622d69f8692a095f476556d15270c
https://pubmed.ncbi.nlm.nih.gov/28295633
https://pubmed.ncbi.nlm.nih.gov/28295633
Autor:
Ichiro Manabe, Yuki Sugiura, Ryozo Nagai, Yoshifumi Yamaguchi, Takayuki Isagawa, Kurara Honda, Masaki Wake, Keimon Sayama, Katsura Soma, Randall S. Johnson, Hajime Abe, Hiroaki Semba, Norihiko Takeda, Manami Katoh, Katsuhiro Koyama, Andrew S. Cowburn, Dana M. R. Jenkins, Jung Whan Kim, Issei Komuro, Nobuhito Goda, Hyunsung Choi, Masayuki Miura, Masataka Asagiri, Hidenobu Miyazawa
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
In severely hypoxic condition, HIF-1α-mediated induction of Pdk1 was found to regulate glucose oxidation by preventing the entry of pyruvate into the tricarboxylic cycle. Monocyte-derived macrophages, however, encounter a gradual decrease in oxygen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0784b57733fc30c52cee05356570b74
http://europepmc.org/articles/PMC4873978
http://europepmc.org/articles/PMC4873978
Autor:
Masayuki Miura, Makoto Suematsu, Kurara Honda, Yoshifumi Yamaguchi, Takehiro Yamamoto, Fumio Matsuda, Hidenobu Miyazawa, Koki Kondo, Yuki Sugiura
Publikováno v:
Development (Cambridge, England)
Adapting the energy metabolism state to changing bioenergetic demands is essential for mammalian development accompanying massive cell proliferation and cell differentiation. However, it remains unclear how developing embryos meet the changing bioene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8140ca0246311c327403b6471185a3fe
https://pubmed.ncbi.nlm.nih.gov/28049690
https://pubmed.ncbi.nlm.nih.gov/28049690