Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Hidenari Hirano"'
Publikováno v:
Biological and Pharmaceutical Bulletin. 25:1084-1089
As a basic approach to identifying the distribution mechanism of quinolone antibiotics into saliva, salivary excretion of five fluoroquinolones, ciprofloxacin (CPFX), norfloxacin (NFLX), lomefloxacin (LFLX), ofloxacin (OFLX) and sparfloxacin (SPFX),
Publikováno v:
YAKUGAKU ZASSHI. 121:153-159
This study was carried out to investigate the effects of Sho-saiko-to (Xiao Chai Hu Tang), a Chinese traditional medicine, on the gastric function including the gastric emptying rate (GER) and intragastric pH in rats. Additionally, the effects of the
Publikováno v:
Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 27:598-604
To supply drug information using documents is very important to ensure patient safety and the proper use of prescribed drugs. Such documents should include easily understandable information for patients. In the development process of drug information
Publikováno v:
Biological and Pharmaceutical Bulletin. 24:409-413
Dissolution rate is considered an important factor affecting absorption and efficacy after the oral administration of tolbutamide. Since in many cases traditional Chinese medicines, including Sho-saiko-to (TJ-9, Xiao Chaihu Tang), are taken with othe
Publikováno v:
The American Journal of Chinese Medicine. 27:355-363
The effects of Sho-saiko-to on the pharmacokinetics of tolbutamide were investigated in rats. After intravenous administration of tolbutamide (5 mg/kg), no significant change in the pharma-cokinetics of tolbutamide was observed in both groups of sing
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 17:1415-1421
A simple and sensitive high-performance liquid chromatographic method for the analysis of acetazolamide (AZ) in rat blood (plasma/serum, whole blood and serum ultrafiltrate), brain tissue and cerebrospinal fluid (CSF) was described. Quantitative extr
Autor:
Takashi Tezen, Nobuhiro Ichikawa, Kohji Naora, Shinichi Takano, Tadanori Itakura, Shyun Yamamoto, Toshihiro Shizuku, Hidenari Hirano, Kikuo Iwamoto
Publikováno v:
Japanese Journal of Hospital Pharmacy. 22:482-489
Publikováno v:
Japanese Journal of Hospital Pharmacy. 21:310-318
Carmofur-loaded microspheres composed of polylactic acid (PLA) with a molecular weight of 20, 000 were prepared as a parenteral dosage form applicable as a sustained release preparation for cancer chemotherapy by a solvent evaporation method on a cle
Autor:
Hidenari Hirano, Kikuo Iwamoto, Kohji Naora, Nobuhiro Ichikawa, Yoshihiro Kano, Sadao Nagasako, Nobuhiro Nishimura
Publikováno v:
Japanese Journal of Hospital Pharmacy. 20:530-536
To investigate the in vitro metabolism of [6]-gingerol, one of the major pharmacological constituents of ginger, in the intestine, [6]-gingerol was added to the jejunal mucosal and muscular tissue homogenates isolated from rats in high (50μg/ml) and
Publikováno v:
Japanese Journal of Hospital Pharmacy. 20:466-473
Beta-methyldigoxin (MD), a new semi-synthesized cardiac glycoside, has been widely used for treatment of congestive heart failure. Since any dosage form other than tablet form is not commercially available for MD, it has been necessary to prepare pow