Autocitrullination and Changes in the Activity of Peptidylarginine Deiminase 3 Induced by High Ca2+ Concentrations

Autor: Mizuki Sawata, Hiroki Shima, Kazutaka Murayama, Toshitaka Matsui, Kazuhiko Igarashi, Kazumasa Funabashi, Kenji Ite, Kenji Kizawa, Hidenari Takahara, Masaki Unno

Publikováno v: ACS Omega. 7:28378-28387

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1db649ef93554249d0e7fd04ceeb926
https://doi.org/10.1021/acsomega.2c02972

Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases

Autor: Michel Simon, Marie Claire Mechin, Hidenari Takahara

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2020, 21 (2), pp.566. ⟨10.3390/ijms21020566⟩
International Journal of Molecular Sciences, Vol 21, Iss 2, p 566 (2020)
International Journal of Molecular Sciences, 2020, 21 (2), pp.566. ⟨10.3390/ijms21020566⟩

International audience; Deimination, also known as citrullination, corresponds to the conversion of the amino acid arginine, within a peptide sequence, into the non-standard amino acid citrulline. This post-translational modification is catalyzed by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d426e953ccb2bd8b6e2833328c6dbfd
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03153570

Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design

Autor: Masaki Unno, Kenji Ite, Anna Nagai, Megumi Akimoto, Paul R. Thompson, Kenichi Kitanishi, Kazumasa Funabashi, Mizuki Sawata, Ryutaro Mashimo, Kenji Kizawa, Hidenari Takahara

Publikováno v: Archives of Biochemistry and Biophysics. 708:108911

Peptidylarginine deiminase type III (PAD3) is an isozyme belonging to the PAD enzyme family that converts arginine to citrulline residue(s) within proteins. PAD3 is expressed in most differentiated keratinocytes of the epidermis and hair follicles, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1025ae6b97a1f73b45f231ce6f287d74
https://doi.org/10.1016/j.abb.2021.108911

Peptidylarginine Deiminase Inhibitor Cl-Amidine Attenuates Cornification and Interferes with the Regulation of Autophagy in Reconstructed Human Epidermis

Autor: Paul R. Thompson, Hidenari Takahara, Laura Cau, Guy Serre, Michel Simon, Marie-Claire Méchin

Publikováno v: Journal of Investigative Dermatology
Journal of Investigative Dermatology, 2019, 139 (9), pp.1889-1897.e4. ⟨10.1016/j.jid.2019.02.026⟩
Journal of Investigative Dermatology, Nature Publishing Group, 2019, 139 (9), pp.1889-1897.e4. ⟨10.1016/j.jid.2019.02.026⟩
J Invest Dermatol

International audience; Deimination, a post-translational modification catalyzed by a family of enzymes called peptidylarginine deiminases (PADs), is the conversion of arginine into citrulline residues in a protein. Deimination has been associated wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f9749a5b19b13328a286eb478c2584
https://ut3-toulouseinp.hal.science/hal-03156447/document

A History of Deimination Research in Japan: The Founding Fathers

Autor: Hidenari Takahara

Publikováno v: Protein Deimination in Human Health and Disease ISBN: 9783319582436

The research on protein deimination and the enzymes responsible for catalyzing this posttranslational modification started from investigations of the hair follicle and myelin in central nerve system. About 60 years ago, in 1958, the presence of prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d81252c98b04b1121e782738bae6e364
https://doi.org/10.1007/978-3-319-58244-3_1