Zobrazeno 1 - 10
of 304
pro vyhledávání: '"Hidenao, Sasaki"'
Autor:
Hidenori Homma, Yuki Yoshioka, Kyota Fujita, Shinichi Shirai, Yuka Hama, Hajime Komano, Yuko Saito, Ichiro Yabe, Hideyuki Okano, Hidenao Sasaki, Hikari Tanaka, Hitoshi Okazawa
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-19 (2024)
Abstract Better understanding of the earliest molecular pathologies of all neurodegenerative diseases is expected to improve human therapeutics. We investigated the earliest molecular pathology of spinocerebellar ataxia type 1 (SCA1), a rare familial
Externí odkaz:
https://doaj.org/article/2b5f357966984137a40f33a05396b619
Autor:
Hisashi Uwatoko, Yuka Hama, Ikuko Takahashi Iwata, Shinichi Shirai, Masaaki Matsushima, Ichiro Yabe, Jun Utsumi, Hidenao Sasaki
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-10 (2019)
Abstract MicroRNAs (miRNAs) are endogenous small (18–25 nt), single-stranded, non-coding RNAs that play key roles in post-transcriptional gene expression regulation. The expression profiles of miRNAs in biofluids and tissues change in various disea
Externí odkaz:
https://doaj.org/article/c5d4f82c2c2e4de695ec27524b6f93f0
Autor:
Hidenao Sasaki, Asako Takei, Masaaki Matsushima, Ken Sakushima, Yasuhiro Kanatani, Naoki Nishimoto, Takeshi Matsuoka, Jun Sawada, Haruo Uesugi, Kazuya Sako, Shun Shimohama, Seiji Kikuchi
Publikováno v:
BMJ Open, Vol 11, Iss 2 (2021)
Objectives Multiple system atrophy (MSA) is a refractory neurodegenerative disease, but novel treatments are anticipated. An accurate natural history of MSA is important for clinical trials, but is insufficient. This regional registry was launched to
Externí odkaz:
https://doaj.org/article/aec6b9d1912147dfb19ddf3fbb9c81dc
Autor:
Takuma Ohmichi, Takashi Kasai, Makiko Shinomoto, Jun Matsuura, Takashi Koizumi, Fukiko Kitani-Morii, Harutsugu Tatebe, Hidenao Sasaki, Toshiki Mizuno, Takahiko Tokuda
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Caffeine is considered to be a neuroprotective agent against Parkinson's disease (PD) and is expected to offer a blood-based biomarker for the disease. We herein investigated the ability of this biomarker to discriminate between PD and neurodegenerat
Externí odkaz:
https://doaj.org/article/9fd87767385e4b8eb25577f7a1f5ef65
Autor:
Ryoji Naganuma, Ichiro Yabe, Megumi Takeuchi, Kirari Morishita, Shingo Nakane, Ryoken Takase, Ikuko Takahashi-Iwata, Masaaki Matsushima, Mika Otsuki, Hideaki Shiraishi, Hidenao Sasaki
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0232808 (2020)
Studies on evoked responses in Parkinson's disease (PD) may be useful for elucidating the etiology and quantitative evaluation of PD. However, in previous studies, the association between evoked responses and detailed motor symptoms or cognitive func
Externí odkaz:
https://doaj.org/article/ac29a694e53b4daaaabb42c2ba35328f
Autor:
Haruto Uchino, Masaki Ito, Ken Kazumata, Yuka Hama, Shuji Hamauchi, Shunsuke Terasaka, Hidenao Sasaki, Kiyohiro Houkin
Publikováno v:
BMC Medical Genomics, Vol 11, Iss 1, Pp 1-10 (2018)
Abstract Background Moyamoya disease (MMD) is characterized by progressive stenosis of intracranial arteries in the circle of Willis with unknown etiology even after the identification of a Moyamoya susceptible gene, RNF213. Recently, differences in
Externí odkaz:
https://doaj.org/article/dbd944def16e481787dafe73b1b549fd
Autor:
Kunikazu Tanji, Fumiaki Mori, Yasuo Miki, Jun Utsumi, Hidenao Sasaki, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi
Publikováno v:
Neurobiology of Disease, Vol 112, Iss , Pp 14-23 (2018)
Ubiquitination, a fundamental post-translational modification of intracellular proteins, is enzymatically reversed by deubiquitinase enzymes (deubiquitinases). >90 deubiquitinases have been identified. One of these enzymes, YOD1, possesses deubiquiti
Externí odkaz:
https://doaj.org/article/b51c0079eabe4dbdbb3e8d404e077029
Autor:
Yuka Hama, Masataka Katsu, Ichigaku Takigawa, Ichiro Yabe, Masaaki Matsushima, Ikuko Takahashi, Takayuki Katayama, Jun Utsumi, Hidenao Sasaki
Publikováno v:
Molecular Brain, Vol 10, Iss 1, Pp 1-11 (2017)
Abstract Genomic variation includes single-nucleotide variants, small insertions or deletions (indels), and copy number variants (CNVs). CNVs affect gene expression by altering the genome structure and transposable elements within a region. CNVs are
Externí odkaz:
https://doaj.org/article/2fcde5f2d7ed4c07bd06dcee62d07bf7
Autor:
Yasuo Nakahara, Jun Mitsui, Hidetoshi Date, Kristine Joyce Porto, Yasuhiro Hayashi, Atsushi Yamashita, Yoshio Kusakabe, Takashi Matsukawa, Hiroyuki Ishiura, Tsutomu Yasuda, Atsushi Iwata, Jun Goto, Yaeko Ichikawa, Yoshio Momose, Yuji Takahashi, Tatsushi Toda, Rikifumi Ohta, Jun Yoshimura, Shinichi Morishita, Emil K Gustavsson, Darren Christy, Melissa Maczis, Matthew J. Farrer, Han-Joon Kim, Sung-Sup Park, Beomseok Jeon, Jin Zhang, Weihong Gu, Sonja W. Scholz, Andrew B. Singleton, Henry Houlden, Ichiro Yabe, Hidenao Sasaki, Masaaki Matsushima, Hiroshi Takashima, Akio Kikuchi, Masashi Aoki, Kenju Hara, Akiyoshi Kakita, Mitsunori Yamada, Hitoshi Takahashi, Osamu Onodera, Masatoyo Nishizawa, Hirohisa Watanabe, Mizuki Ito, Gen Sobue, Kinya Ishikawa, Hidehiro Mizusawa, Kazuaki Kanai, Satoshi Kuwabara, Kimihito Arai, Shigeru Koyano, Yoshiyuki Kuroiwa, Kazuko Hasegawa, Tatsuhiko Yuasa, Kenichi Yasui, Kenji Nakashima, Hijiri Ito, Yuishin Izumi, Ryuji Kaji, Takeo Kato, Susumu Kusunoki, Yasushi Osaki, Masahiro Horiuchi, Ken Yamamoto, Mihoko Shimada, Taku Miyagawa, Yosuke Kawai, Nao Nishida, Katsushi Tokunaga, Alexandra Dürr, Alexis Brice, Alessandro Filla, Thomas Klockgether, Ullrich Wüllner, Caroline M. Tanner, Walter A. Kukull, Virginia M.-Y. Lee, Eliezer Masliah, Phillip A. Low, Paola Sandroni, Laurie Ozelius, Tatiana Foroud, Shoji Tsuji
To elucidate the molecular basis of multiple system atrophy (MSA), a neurodegenerative disease, we conducted a genome-wide association study (GWAS) in a Japanese MSA case/control series followed by replication studies in Japanese, Korean, Chinese, Eu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0ca23eb995d2b34d1429411448aeb26
https://doi.org/10.1101/2023.05.02.23289328
https://doi.org/10.1101/2023.05.02.23289328
Autor:
Kentaro Yoshii, Ikuko Takahashi-Iwata, Shinichi Shirai, Shintaro Kobayashi, Ichiro Yabe, Hidenao Sasaki
Publikováno v:
Microorganisms, Vol 8, Iss 11, p 1672 (2020)
Tick-borne encephalitis (TBE) is a zoonotic disease that usually presents as a moderate febrile illness followed by severe encephalitis, and various neurological symptoms are observed depending on the distinct central nervous system (CNS) regions aff
Externí odkaz:
https://doaj.org/article/e2e3d0f3d7e74480ba3df1fc01bdaaf9