Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Hidemasa Katsumi"'
Autor:
Hidemasa Katsumi, Sho Kitada, Shintaro Yasuoka, Rie Takashima, Tomoki Imanishi, Rina Tanaka, Satoru Matsuura, Hiroyuki Kimura, Hidekazu Kawashima, Masaki Morishita, Akira Yamamoto
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1946 (2022)
In the present study, L-serine (Ser)-modified poly-L-lysine (PLL) was synthesized to develop a biodegradable, kidney-targeted drug carrier for efficient radionuclide therapy in renal cell carcinoma (RCC). Ser-PLL was labeled with 111In/90Y via diethy
Externí odkaz:
https://doaj.org/article/91dbc3c07233444ba57cd9aac5c41774
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 568 (2022)
To optimize the characteristics of stereocomplex polylactide-b-polyethylene glycol nanoparticles (SC-PEG NPs) in terms of pharmacokinetics (PK), we chose continuous anti-solvent precipitation with a T-junction as a preparation method and investigated
Externí odkaz:
https://doaj.org/article/880a4767b782413f888ead855946fa7f
Autor:
Hiroki Ukai, Kazuki Iwasa, Takamasa Deguchi, Masaki Morishita, Hidemasa Katsumi, Akira Yamamoto
Publikováno v:
Pharmaceutics, Vol 12, Iss 5, p 462 (2020)
Labrasol® is a self-emulsifying excipient that contains saturated polyglycolysed C6–C14 glycerides and this additive is known to improve the intestinal absorption of poorly absorbed drugs after oral administration. However, the effects of formulat
Externí odkaz:
https://doaj.org/article/24d78aa93a6944a88d88802c9c91ec8c
Autor:
Tomoyuki Furubayashi, Daisuke Inoue, Noriko Nishiyama, Akiko Tanaka, Reiko Yutani, Shunsuke Kimura, Hidemasa Katsumi, Akira Yamamoto, Toshiyasu Sakane
Publikováno v:
Pharmaceutics, Vol 12, Iss 1, p 79 (2020)
Recently, various types of cultured cells have been used to research the mechanisms of transport and metabolism of drugs. Although many studies using cultured cell systems have been published, a comparison of different cultured cell systems has never
Externí odkaz:
https://doaj.org/article/4f60b67f5cc64d0fa46c41ede7e3ddfb
Autor:
Tammam Alama, Kosuke Kusamori, Masaki Morishita, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto
Publikováno v:
Pharmaceutics, Vol 11, Iss 4, p 170 (2019)
Generally, the use of absorption enhancers might be the most effective approaches to ameliorate the enteric absorption of poorly absorbed substances. Among numerous absorption enhancers, we already reported that a gemini surfactant, sodium dilauramid
Externí odkaz:
https://doaj.org/article/6cd08605ed1346db80493b590565961c
Autor:
Satoru Matsuura, Hidemasa Katsumi, Hiroe Suzuki, Natsuko Hirai, Rie Takashima, Masaki Morishita, Toshiyasu Sakane, Akira Yamamoto
Publikováno v:
Pharmaceutics, Vol 10, Iss 4, p 251 (2018)
l-cysteine (Cys)- and l-serine (Ser)-modified, third-generation polyamidoamine (PAMAM) dendrimer with multiple reduced thiols (Ser-PAMAM-Cys) was synthesized as a kidney-targeting reactive oxygen species (ROS) scavenger to help prevent renal ischemia
Externí odkaz:
https://doaj.org/article/20cecb29c0eb46bd81d3c66890e68917
Autor:
Akiko Tanaka, Tomoyuki Furubayashi, Akifumi Matsushita, Daisuke Inoue, Shunsuke Kimura, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0159150 (2016)
The nasal absorption of macromolecules from powder formulations and the effect of sodium carboxymethyl cellulose (CMC-Na) as a pharmaceutical excipient on their absorption were studied. Model macromolecules were fluorescein isothiocyanate-labeled dex
Externí odkaz:
https://doaj.org/article/cf92a3bedd574651899f3a4f9a0be453
Autor:
Chihiro Naito, Hidemasa Katsumi, Tomoko Suzuki, Ying-shu Quan, Fumio Kamiyama, Toshiyasu Sakane, Akira Yamamoto
Publikováno v:
Pharmaceutics, Vol 10, Iss 4, p 215 (2018)
Human parathyroid hormone (1-34) (PTH) has been widely used as the subcutaneous injection formulation for the treatment of osteoporosis. In the present study, we developed an efficient transdermal delivery system of PTH by using dissolving microneedl
Externí odkaz:
https://doaj.org/article/a7e9b467d2064298b7633e28e9b4173c
Autor:
Hidemasa Katsumi, Jun-Ichi Sano, Makiya Nishikawa, Keiko Hanzawa, Toshiyasu Sakane, Akira Yamamoto
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135966 (2015)
To establish a rational molecular design for bisphosphonate (BP)-modified proteins for efficient bone targeting, a pharmacokinetic study was performed using a series of alendronate (ALN), a nitrogen-containing BP, modified proteins with various molec
Externí odkaz:
https://doaj.org/article/27dc9089af4e497a9dfab7b86aa373e6
Autor:
Hidemasa Katsumi, Yutaro Tanaka, Kaori Hitomi, Shu Liu, Ying-shu Quan, Fumio Kamiyama, Toshiyasu Sakane, Akira Yamamoto
Publikováno v:
Pharmaceutics, Vol 9, Iss 3, p 29 (2017)
To improve the transdermal bioavailability and safety of alendronate (ALN), a nitrogen-containing bisphosphonate, we developed self-dissolving microneedle arrays (MNs), in which ALN is loaded only at the tip portion of micron-scale needles by a dip-c
Externí odkaz:
https://doaj.org/article/c099ec5352f04f9499b9f750eea2316b