Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Hideki Ukawa"'
Publikováno v:
Alimentary Pharmacology & Therapeutics. 16:74-82
Background/aims: Endogenous prostaglandins (PGs) are considered to play a pivotal role in maintaining the mucosal integrity of the stomach after injury. In the present study, we evaluated the mucosal ulcerogenic and mucosal blood flow (GMBF) response
Publikováno v:
Digestive Diseases and Sciences. 46:1690-1699
The gastric toxic effects of aspirin (ASA) and NCX-4016, a nitric oxide (NO)-releasing ASA, were compared in normal, cirrhotic, and arthritic rats. Oral administration of ASA (100 mg/kg) produced hemorrhagic lesions on the gastric mucosa in normal ra
Publikováno v:
Alimentary Pharmacology & Therapeutics. 14:116-124
Summary Aim: To investigate the EP receptor subtype involved in the gastroprotective action of prostaglandin (PG) E2 using various EP receptor agonists in rats, and using knockout mice lacking EP1 or EP3 receptors. Methods: Male SD rats and C57BL/6 m
Autor:
Koji Takeuchi, Hideo Araki, Shinichi Kato, Hideki Ukawa, Yukihiko Sugimoto, Shuh Narumiya, Osamu Furukawa, Fumitaka Ushikubi, Atsusi Ichikawa
Publikováno v:
Gastroenterology. 117:1128-1135
Background & Aims: To examine the involvement of EP 3 receptors in physiological regulation of duodenal HCO 3 − secretion, we disrupted the gene encoding EP receptors in mice by homologous recombination and evaluated acid-induced HCO 3 − secretio
Publikováno v:
Digestive Diseases and Sciences. 43:2003-2011
Effects of selective cyclooxygenase-2 (COX-2)inhibitors (NS-398) and nitric oxide (NO)-releasingaspirin (NO-ASA) on gastric ulcerogenic and healingresponses were examined in comparison with nonselective COX inhibitors such as indomethacin and aspirin
Publikováno v:
Gastroenterology. 113:1553-1559
BACKGROUND & AIMS: Receptors activated by prostaglandin (PG) E2 are pharmacologically subdivided into four subtypes (EP1-EP4). The EP- receptor subtype(s) involved in stimulation of gastroduodenal HCO3- secretion in rats were investigated. METHODS: U
Publikováno v:
British Journal of Pharmacology. 122:447-454
1 We examined the effects of selective and nonselective cyclo-oxygenase (COX) inhibitors on various functional changes in the rat stomach induced by topical application of taurocholate (TC) and investigated the preferential role of COX isozymes in th
Publikováno v:
Life Sciences. 61:1603-1611
Effects of the selective cyclooxygenase-2 (COX-2) inhibitors such as NS-398 and nimesulide on duodenal HCO3− secretory and ulcerogenic responses to mucosal acidification were examined in rats, in comparison with indomethacin, a nonselective COX inh
Autor:
Tadashi Kurimoto, Zen Itoh, Naoyoshi Miura, Toshiko Kinomoto, Takeshi Omata, Tomoyuki Yoneta, Runa Eta, Youichi Fukuda, Yukinori Mera, Hideki Ukawa
Publikováno v:
Gastroenterology. 120:A311
Autor:
Zen Itoh, Tomoyuki Yoneta, Naoyoshi Miura, Hitoshi Morita, Tadashi Kurimoto, Hideki Ukawa, Hiroshi Suda, Yuko Hori, Yugo Matsunaga
Publikováno v:
Gastroenterology. 120:A311-A311