Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Hideki Terashima"'
Autor:
Ken Ishii, Munefumi Torihata, Eisuke Tsuda, Keiichi Yotsumoto, Hideki Terashima, Isao Yasumatsu, Takashi Ishiyama, Katagiri Takahiro, Katsushi Katayama, Makoto Suzuki, Kumiko Hiramoto, Tsuyoshi Muto
Publikováno v:
ACS Med Chem Lett
[Image: see text] Therapeutic reactivation of the γ-globin genes for fetal hemoglobin (HbF) production is an attractive strategy for treating β-thalassemia and sickle cell disease. It was reported that genetic knockdown of the histone lysine methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac9b7958989207e99cc953ca19a627c
https://doi.org/10.1021/acsmedchemlett.0c00572
https://doi.org/10.1021/acsmedchemlett.0c00572
Autor:
Hideki Terashima, Misato Aonuma, Mikio Kato, Hiroshi Tsuchida, Kotaro Sugimoto, Mika Yokoyama
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 54:31-38
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease, and consequently, effective antifibrotic drugs are strongly desired. Although we have previously reported a validated Col1a1-Luc Tg rat model for fibrosis, there are only a few m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8212c8f11318cbd7fef79a6ebd743e9a
https://doi.org/10.1016/j.pupt.2018.11.005
https://doi.org/10.1016/j.pupt.2018.11.005
Autor:
Tomoyuki Tsunemi, Tomohiro Makino, Kazuo Miyazaki, Hideki Terashima, Kyoko Yamashiro, Katsushi Katayama, Maki Terakawa, Hiroaki Maeda, Kouichi Uoto, Munetada Haruyama, Ryosuke Yoshioka
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(19)
Pharmacological reactivation of the γ-globin gene for the production of fetal hemoglobin (HbF) is a promising approach for the management of β-thalassemia and sickle cell disease (SCD). We conducted a phenotypic screen in human erythroid progenitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ba426550decb5cd6a9356583181101
https://pubmed.ncbi.nlm.nih.gov/32717372
https://pubmed.ncbi.nlm.nih.gov/32717372
Autor:
Kyoko Yamashiro, Hiroaki Maeda, Hideki Terashima, Tomoyuki Tsunemi, Tomohiro Makino, Katsushi Katayama, Ryosuke Yoshioka, Kazuo Miyazaki, Munetada Haruyama, Maki Terakawa
Publikováno v:
Biochemical Pharmacology. 171:113717
Heritable disorders associated with hemoglobin production are the most common monogenic disorders. These are mainly represented by disorders such as β-thalassemia and sickle cell disease. Induction of fetal hemoglobin (HbF) has been known to amelior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63bc954411e2378fc0c617911d6e3fa3
https://doi.org/10.1016/j.bcp.2019.113717
https://doi.org/10.1016/j.bcp.2019.113717
Autor:
Toshiyuki Nakanishi, Madoka Hoshino, Yu Ohki, Kazuishi Kubota, Hiroki Shimizu, Hideki Kobayashi, Tomio Ishikawa, Hidetaka Sakurai, Yasunori Muramatsu, Hiroyuki Tsuruoka, Tomoko Ogiyama, Hideki Terashima, Shojiro Miyazaki
Publikováno v:
Cell chemical biology. 26(1)
Molecular target identification of small molecules, so-called target deconvolution, is a major obstacle to phenotype-based drug discovery. Here, we developed an approach called perturbation-based proteomic correlation profiling (PPCP) utilizing the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::665d5079cf04843f0ae211a9a73dd37e
https://pubmed.ncbi.nlm.nih.gov/30449674
https://pubmed.ncbi.nlm.nih.gov/30449674
Autor:
Satoko Wakimoto, Tsuneaki Ogata, Jun Ohsumi, Keita Kono, Yoshikazu Uto, Nobuya Kurikawa, Hideki Terashima, Toshiyuki Takagi
Publikováno v:
Biological and Pharmaceutical Bulletin. 36:259-267
Stearoyl-CoA desaturase-1 (SCD-1) catalyzes the biosynthesis of monounsaturated fatty acids, and their abnormality is possibly responsible for obesity, insulin resistance, hepatic steatosis and nonalcoholic steatohepatitis (NASH). A novel SCD-1 inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927dfc1ad0bfb12c86e664bbd9bb0562
https://doi.org/10.1248/bpb.b12-00702
https://doi.org/10.1248/bpb.b12-00702
Publikováno v:
American Journal of Physiology-Renal Physiology. 299:F792-F801
Fibrosis is the final common pathway for various tissue lesions that lead to chronic progressive organ failure, and consequently effective antifibrotic drugs are strongly desired. However, there are few animal models in which it is possible to evalua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aaa40334ce401822f0a6aaed023b4fb
https://doi.org/10.1152/ajprenal.00141.2009
https://doi.org/10.1152/ajprenal.00141.2009
Publikováno v:
Zisin (Journal of the Seismological Society of Japan. 2nd ser.). 61:247-254
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1ef56b1b27a02660ba178934c4c7035
https://doi.org/10.4294/zisin.61.247
https://doi.org/10.4294/zisin.61.247
Publikováno v:
Journal of Cardiovascular Pharmacology. 48:135-142
The effect of olmesartan medoxomil (OLM), an angiotensin II receptor blocker (ARB), on advanced nephropathy and mortality was evaluated in Zucker Diabetic Fatty (ZDF) rats, a type 2 diabetes model. OLM was administered from 36 weeks of age, when the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b5e2c41cec720359635b62e12208d08
https://doi.org/10.1097/01.fjc.0000245241.79959.d6
https://doi.org/10.1097/01.fjc.0000245241.79959.d6
Autor:
Kanae Suzuki, Toshio Sada, Yoshikazu Nezu, Hideki Terashima, Mikio Kato, Hideki Kobayashi, Masayuki Ebisawa
Publikováno v:
European journal of pharmacology. 734
R-268712 is a novel and specific inhibitor of activin receptor-like kinase 5 (ALK5), a transforming growth factor β (TGF-β) type I receptor. Evaluation of in vitro inhibition indicated that R-268712 is a potent and selective inhibitor of ALK5 with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c418866505a8d2469a2e796a1a829d9b
https://pubmed.ncbi.nlm.nih.gov/24726873
https://pubmed.ncbi.nlm.nih.gov/24726873