Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Hideki Sakagami"'
Autor:
Sadao Kuromitsu, Masaaki Hirano, Hiroyuki Koshio, Masahiro Takeuchi, Masamichi Mori, Yosuke Yamanaka, Masatoshi Yuri, Takahiro Matsuya, Hiroko Yamamoto, Satoshi Konagai, Naoki Kaneko, Hideki Sakagami, Hiroaki Tanaka
First- and second-generation EGFR tyrosine kinase inhibitors (TKI) are effective clinical therapies for patients with non–small cell lung cancer (NSCLC) harboring EGFR-activating mutations. However, almost all patients develop resistance to these d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::399d07bd79a380532a2aac2679fb5fc0
https://doi.org/10.1158/1535-7163.c.6538642.v1
https://doi.org/10.1158/1535-7163.c.6538642.v1
Autor:
Sadao Kuromitsu, Masafumi Kudoh, Hitoshi Doihara, Takashi Furutani, Hideki Sakagami, Takatoshi Soga, Nobuaki Shindou, Kenichi Mori, Rika Saito, Yutaka Kondoh, Itsuro Shimada, Hiroshi Fushiki, Satoshi Konagai, Yoko Ueno, Masamichi Mori
Activation of anaplastic lymphoma receptor tyrosine kinase (ALK) is involved in the pathogenesis of several carcinomas, including non–small cell lung cancer (NSCLC). Echinoderm microtubule–associated protein like 4 (EML4)-ALK, which is derived fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37459d8fd025c0aa252300682e939c06
https://doi.org/10.1158/1535-7163.c.6536752.v1
https://doi.org/10.1158/1535-7163.c.6536752.v1
Autor:
Sadao Kuromitsu, Masafumi Kudoh, Hitoshi Doihara, Takashi Furutani, Hideki Sakagami, Takatoshi Soga, Nobuaki Shindou, Kenichi Mori, Rika Saito, Yutaka Kondoh, Itsuro Shimada, Hiroshi Fushiki, Satoshi Konagai, Yoko Ueno, Masamichi Mori
PDF file - 64K, Inhibition of ALK phosphorylation and signal transduction in NCI-H2228 cells by ASP3026.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8191a9c270c42509f89630903befdd52
https://doi.org/10.1158/1535-7163.22501333.v1
https://doi.org/10.1158/1535-7163.22501333.v1
Autor:
Sadao Kuromitsu, Masafumi Kudoh, Hitoshi Doihara, Takashi Furutani, Hideki Sakagami, Takatoshi Soga, Nobuaki Shindou, Kenichi Mori, Rika Saito, Yutaka Kondoh, Itsuro Shimada, Hiroshi Fushiki, Satoshi Konagai, Yoko Ueno, Masamichi Mori
PDF file - 82K, Inhibitory activity of ASP3026 and crizotinib against various TKs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21313f18e6abbb4228948c2e5e3dabe4
https://doi.org/10.1158/1535-7163.22501336
https://doi.org/10.1158/1535-7163.22501336
Autor:
Sadao Kuromitsu, Masafumi Kudoh, Hitoshi Doihara, Takashi Furutani, Hideki Sakagami, Takatoshi Soga, Nobuaki Shindou, Kenichi Mori, Rika Saito, Yutaka Kondoh, Itsuro Shimada, Hiroshi Fushiki, Satoshi Konagai, Yoko Ueno, Masamichi Mori
PDF file - 445K, Growth of H2228-luc cells directly inoculated into the pleural cavity of NOD/SCID mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bad5dc227138cbf524227b69d2b4a26
https://doi.org/10.1158/1535-7163.22501345.v1
https://doi.org/10.1158/1535-7163.22501345.v1
Autor:
Tomoko Betsuyaku, Kenzo Soejima, Hideki Sakagami, Shinya Mimasu, Tatsuya Niimi, Katsuhiko Naoki, Ichiro Kawada, Keita Masuzawa, Shigenari Nukaga, Junko Hamamoto, Hiroyuki Yasuda, Toshiyuki Hirano
Multiple epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKI) have been developed to effectively inhibit EGFR-derived signals in non–small cell lung cancer (NSCLC). In this study, we assessed the efficacy of EGFR-TKIs, incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f63728dc4a949b18cd18bfd9c4e456bd
https://doi.org/10.1158/1535-7163.c.6537946.v1
https://doi.org/10.1158/1535-7163.c.6537946.v1
Autor:
Sadao Kuromitsu, Masafumi Kudoh, Hitoshi Doihara, Takashi Furutani, Hideki Sakagami, Takatoshi Soga, Nobuaki Shindou, Kenichi Mori, Rika Saito, Yutaka Kondoh, Itsuro Shimada, Hiroshi Fushiki, Satoshi Konagai, Yoko Ueno, Masamichi Mori
PDF file - 56K, Pharmacokinetic parameters of ASP3026 after 5-day repeated oral dosing of ASP3026 in NOD/SCID mice xenografted with NCI-H2228 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bcfa7353e927b74fbd7543ff62e1c46
https://doi.org/10.1158/1535-7163.22501330
https://doi.org/10.1158/1535-7163.22501330
Autor:
Sadao Kuromitsu, Masafumi Kudoh, Hitoshi Doihara, Takashi Furutani, Hideki Sakagami, Takatoshi Soga, Nobuaki Shindou, Kenichi Mori, Rika Saito, Yutaka Kondoh, Itsuro Shimada, Hiroshi Fushiki, Satoshi Konagai, Yoko Ueno, Masamichi Mori
PDF file - 68K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ee04571291c1ce223e22fc3eb6ccd9
https://doi.org/10.1158/1535-7163.22501339.v1
https://doi.org/10.1158/1535-7163.22501339.v1
Autor:
Tomoko Betsuyaku, Kenzo Soejima, Hideki Sakagami, Shinya Mimasu, Tatsuya Niimi, Katsuhiko Naoki, Ichiro Kawada, Keita Masuzawa, Shigenari Nukaga, Junko Hamamoto, Hiroyuki Yasuda, Toshiyuki Hirano
Table S1:IC50 values of EGFR-TKIs for lung cancer cell lines. Table S2:IC50 values of EGFR-TKIs for Ba/F3 cells harboring EGFR exon 20 insertion mutations. Table S3:IC50 values of EGFR-TKIs for Ba/F3 cells harboring EGFR L858R or L858R+Y764_V765insHH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755b2f885ea3f1f1a3bdc8b940846f70
https://doi.org/10.1158/1535-7163.22505092
https://doi.org/10.1158/1535-7163.22505092
Autor:
Shigenari Nukaga, Hiroyuki Yasuda, Tomoko Betsuyaku, Keita Masuzawa, Tatsuya Niimi, Hideki Sakagami, Junko Hamamoto, Katsuhiko Naoki, Toshiyuki Hirano, Ichiro Kawada, Kenzo Soejima, Shinya Mimasu
Publikováno v:
Molecular Cancer Therapeutics. 17:740-750
Multiple epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKI) have been developed to effectively inhibit EGFR-derived signals in non–small cell lung cancer (NSCLC). In this study, we assessed the efficacy of EGFR-TKIs, incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b738cbeed5a1f11d22ac604f9139bdc8
https://doi.org/10.1158/1535-7163.mct-17-1033
https://doi.org/10.1158/1535-7163.mct-17-1033
