Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Hideki Kizawa"'
Publikováno v:
Biochemistry and Biophysics Reports, Vol 10, Iss C, Pp 186-191 (2017)
The liver plays a central role in metabolism. Although many studies have described in vitro liver models for drug discovery, to date, no model has been described that can stably maintain liver function. Here, we used a unique, scaffold-free 3D bio-pr
Externí odkaz:
https://doaj.org/article/c276eb7cadc641c59a98341e7367a7dd
Autor:
Ajaya R. Shrestha, Haishun Piao, Naoshi Kojima, Ryoji Kurita, Hideki Kizawa, Takuya Akisawa, Yoshihiro Ohmiya
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 39:258-269
The properties of gapmer antisense oligonucleotide (ASO) flanked by deoxyribonucleic guanidine (DNG) were investigated for the potential application in antisense technology. DNG is a unique nucleotide analog which has a positively charged internucleo
Publikováno v:
Biochemistry and Biophysics Reports, Vol 10, Iss C, Pp 186-191 (2017)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
The liver plays a central role in metabolism. Although many studies have described in vitro liver models for drug discovery, to date, no model has been described that can stably maintain liver function. Here, we used a unique, scaffold-free 3D bio-pr
Autor:
Hideki Kizawa1,2, Ikuyo Kou1, Aritoshi Iida3, Akihiro Sudo4, Yoshinari Miyamoto1, Akira Fukuda5, Akihiko Mabuchi1, Akihiro Kotani6, Akira Kawakami7, Seizo Yamamoto8, Atsumasa Uchida4, Kozo Nakamura5, Kohei Notoya2, Yusuke Nakamura3, Shiro Ikegawa1 sikegawa@ims.u-tokyo.ac.jp
Publikováno v:
Nature Genetics. Feb2005, Vol. 37 Issue 2, p138-144. 7p.
Autor:
Akira Kurose, Kazuki Masu, Shunrou Fujiwara, Hideki Kizawa, Makoto Sasaki, Hiroshi Kashimura, Takaaki Beppu, Kuniaki Ogasawara
Publikováno v:
Neurologia medico-chirurgica. 49:430-433
Proton magnetic resonance spectroscopy, diffusion-weighted axonography, and diffusion tensor tractography in a patient with tumefactive demyelination plaque (TDP) were evaluated for differential diagnosis from glioblastoma. The findings of glutamate
Publikováno v:
Journal of Human Genetics. 51:151-154
Osteoarthritis (OA) is a very common bone and joint disease characterized by breakdown of cartilage in the joint. We recently found that an aspartic-acid repeat polymorphism of the asporin gene (ASPN) on chromosome 9 is associated with susceptibility
Autor:
Akihiko Mabuchi, Aritoshi Iida, Hideki Kizawa, Akira Kawakami, Shiro Ikegawa, Yusuke Nakamura, Atsumasa Uchida, Ikuyo Kou, Seizo Yamamoto, Kohei Notoya, Akihiro Kotani, Akihiro Sudo, Kozo Nakamura, Yoshinari Miyamoto, Akira Fukuda
Publikováno v:
Nature Genetics. 37:138-144
Osteoarthritis is the most common form of human arthritis. We investigated the potential role of asporin, an extracellular matrix component expressed abundantly in the articular cartilage of individuals with osteoarthritis, in the pathogenesis of ost
Autor:
Hideki Kizawa, Yuriko Nagane, Hideo Tohgi, Kimiaki Utsugisawa, Yoko Iwa, Yasuo Terayama, Ryushi Kondoh, Hitomi Akutsu
Publikováno v:
Thrombosis and Haemostasis. 94:1012-1018
SummaryIn order to define the role of angiotensin II (AngII) receptor subtypes, AT1 and AT2, in platelet activation, we examined the effects of AngII and receptor antagonists on both aggregability and phosphorylation status of protein kinase C (PKC)
Autor:
Yasuhiro Tanaka, Masahiko Fujino, Yukio Fujisawa, Rie Satoh, Shoichi Okubo, Hideyuki Tanaka, Kazuhiro Ogi, Ryo Fujii, Minoru Maruyama, Shuji Hinuma, Masataka Harada, Hiroshi Uejima, Tokuyuki Shinohara, Yasuaki Itoh, Hidetoshi Komatsu, Yuji Kawamata, Shoji Fukusumi, Masaki Hosoya, Makoto Kobayashi, Hideki Kizawa, Yuko Noguchi, Fumika Matsumura
Publikováno v:
Nature. 422:173-176
Diabetes, a disease in which carbohydrate and lipid metabolism are regulated improperly by insulin, is a serious worldwide health issue. Insulin is secreted from pancreatic beta cells in response to elevated plasma glucose, with various factors modif
Autor:
Shoji Fukusumi, Shuji Hinuma, Masahiko Fujino, Junko Sakamoto, Masaomi Miyamoto, Kazuaki Kitano, Shiro Takekawa, Chieko Kitada, Hideki Kizawa
Publikováno v:
Biochemical and Biophysical Research Communications. 232:157-163
Expressed sequence tags (ESTs) that showed significant homology to rat cortistatin (CST) were found in a human fetal brain cDNA library. A protein coded by the cDNA showed 55% identity to rat preprocortistatin in amino acid. Similarly in the generati