Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Hideki Igisu"'
Autor:
Toshihiko Myojo, Donald Wilson, Mazen S. K. Zaqout, Tomoyuki Sumizawa, Hideki Igisu, Susumu Ueno
Publikováno v:
Environmental Health and Preventive Medicine. 17:341-345
Measurement of released lactate dehydrogenase (LDH) activity, a commonly used marker of lethal cell injury in both in vitro and in vivo screenings, has been used to assess the cytotoxicity of nanoparticles (NPs), chemical compounds, and environmental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f14a380f3e585dc94242fd3b2f3872
https://doi.org/10.1007/s12199-011-0245-7
https://doi.org/10.1007/s12199-011-0245-7
Autor:
Tomoyuki Sumizawa, Hideki Igisu
Publikováno v:
The Journal of Toxicological Sciences. 33:117-122
When human neuroblastoma cells (SH-SY5Y) were exposed to 0.5 - 5 mM acrylamide for 18 hr, the levels of heat shock proteins (HSPs) of 90, 70 and 27 kDa (Hsp90, Hsp70, and Hsp27, respectively) were elevated in the incubation media depending on the dos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36836bc5eecec9b917ea817a78475402
https://doi.org/10.2131/jts.33.117
https://doi.org/10.2131/jts.33.117
Publikováno v:
Archives of Toxicology. 80:146-153
Using human neuroblastoma SH-SY5Y cells, effects of acrylamide on p53 protein and intracellular signal transducting pathways were examined. Acrylamide increased p53, phosphorylated p53, and p53-associated protein murine double minute 2 (MDM2). The ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff47b944e014326f1c5ac564fd97c6a5
https://doi.org/10.1007/s00204-005-0022-8
https://doi.org/10.1007/s00204-005-0022-8
Publikováno v:
Journal of UOEH. 26:51-57
Acrylamide inhibits creatine kinase (CK) activities in the brain of rats or mice. However, its effects on genetic expression of CK have not yet been studied. CK mRNA and protein level were examined by RT-PCR and Western blotting, respectively. Neithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875c1cac7a379bd968c3d46e907834f3
https://doi.org/10.7888/juoeh.26.51
https://doi.org/10.7888/juoeh.26.51
Publikováno v:
Environmental Health Perspectives
We examined effects of asbestos exposure on the phosphorylation of p53 protein in human pulmonary epithelial type II cells (A549), which express wild-type p53. In cells exposed to two different types of asbestos, chrysotile (approximately 1-6% iron c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3212f2c9a64cdc8dc1d09e124e785292
https://doi.org/10.1289/ehp.5945
https://doi.org/10.1289/ehp.5945
Publikováno v:
Environmental Health Perspectives
When Jurkat human T cells were incubated with 20 microM of pentachlorophenol (PCP) or its metabolite, tetrachlorohydroquinone (TCHQ), for 10 hr, flow cytometric analyses revealed marked increase in the number of apoptotic cells. DNA fragmentation was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5374be584d331fff6d97f653727cd15e
https://doi.org/10.1289/ehp.02110139
https://doi.org/10.1289/ehp.02110139
Publikováno v:
Inhalation Toxicology. 13:659-669
Rats were exposed to 290 or 495 ppm methyl bromide gas for 6 h/day, 3 times/wk for 4 to 8 wk. Creatine kinase (CK), aspartate aminotransferase (ASAT), and lactate dehydrogenase (LDH) activities and bromide ion concentrations were measured in eight re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748bbd4fcea137f8799c0d3bdc3f7e4e
https://doi.org/10.1080/08958370152409892
https://doi.org/10.1080/08958370152409892
Publikováno v:
Biochemical Pharmacology. 60:1875-1882
When CCRF-CEM cells were incubated with 5-40 microM CdCl(2,) apoptosis was observed most clearly at 10 microM. Prior to the development of apoptosis, mitogen-activated protein kinases (MAPKs), i.e. extracellular signal-regulated protein kinase (ERK),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ec8d074ecb2c1c9c99e5f52afcde36
https://doi.org/10.1016/s0006-2952(00)00510-4
https://doi.org/10.1016/s0006-2952(00)00510-4
Publikováno v:
Brain Research. 873:127-130
Rat brain was examined with 4.7 T proton magnetic resonance (MR). On administering hexachlorophene (HCP) 30 mg/kg/day for 5 days, myelin-rich structures stood out in T2-weighted images. Apparent diffusion coefficient (ADC) was markedly suppressed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981eb865e856bbb3bc933e12cfad8125
https://doi.org/10.1016/s0006-8993(00)02523-3
https://doi.org/10.1016/s0006-8993(00)02523-3
Publikováno v:
Journal of Occupational Health. 42:119-123
Suppression of PentylenetetrazolInduced Seizures and c-fos Expression in Mouse Brain by L-Carnitine: Yoshihisa IRYO, et al. Department of Environmental Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96dca401f58d55d2d2a8aec160c73411
https://doi.org/10.1539/joh.42.119
https://doi.org/10.1539/joh.42.119