Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Hideki Hanawa"'
Autor:
Peiman Hematti, Bum-Kee Hong, Cole Ferguson, Rima Adler, Hideki Hanawa, Stephanie Sellers, Ingeborg E Holt, Craig E Eckfeldt, Yugal Sharma, Manfred Schmidt, Christof von Kalle, Derek A Persons, Eric M Billings, Catherine M Verfaillie, Arthur W Nienhuis, Tyra G Wolfsberg, Cynthia E Dunbar, Boris Calmels
Publikováno v:
PLoS Biology, Vol 2, Iss 12, p e423 (2004)
Murine leukemia virus (MLV)-derived vectors are widely used for hematopoietic stem cell (HSC) gene transfer, but lentiviral vectors such as the simian immunodeficiency virus (SIV) may allow higher efficiency transfer and better expression. Recent stu
Externí odkaz:
https://doaj.org/article/f9c87db291d24f5d8a099e3d42af7c03
Autor:
Hideki Hanawa, Hiroki Yamaguchi, K Dan, Yoshio Mitamura, Koiti Inokuchi, Takashi Shimada, Kazuhiro Sawaguchi, Naoya Uchida, Mitsuharu Inamai
Publikováno v:
Experimental Hematology. 37:701-714
Objective Concerning MLL-AF4 leukemogenesis, previous mouse models suggest that the tumorigenesis capacity of MLL-AF4 alone is insufficient for causing leukemia. Based on the finding that an Fms-like tyrosine kinase 3 (Flt3) gene mutation in the tyro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48627ee076a842f215fa8d4c587093b7
https://doi.org/10.1016/j.exphem.2009.02.007
https://doi.org/10.1016/j.exphem.2009.02.007
Publikováno v:
Molecular Therapy. 17(4):667-674
Hematopoietic cell gene therapy using retroviral vectors has achieved success in clinical trials. However, safety issues regarding vector insertional mutagenesis have emerged. In two different trials, vector insertion resulted in the transcriptional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf7a73d6699fc2280d47178502202e5
Autor:
Hideki Hanawa, Masamichi Ishizaki, Yoshitaka Fukunaga, Hiroshi Takahashi, Koichi Ogawa, Takashi Shimada, Yukihiko Hirai
Publikováno v:
Molecular Genetics and Metabolism. 96:91-96
Fabry disease is caused by the deficiency of lysosomal alpha-galactosidase A (alpha-gal A) and usually develops clinical manifestations during childhood/adolescence. Adult Fabry model mice have been successfully treated by various viral vectors. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033b57edc3a8abc69cd06d79f084e373
https://doi.org/10.1016/j.ymgme.2008.10.017
https://doi.org/10.1016/j.ymgme.2008.10.017
Autor:
Steven Kepes, John C. Obenauer, Hideki Hanawa, John T. Gray, Derek A. Persons, Deiqing Pei, Geoffrey Neale, Cheng Cheng, Phillip W. Hargrove
Publikováno v:
Molecular Therapy. 16:525-533
Although hematopoietic cell gene therapy using retroviral vectors has recently achieved success in clinical trials, safety issues regarding vector insertional mutagenesis have emerged. Vector insertion, resulting in transcriptional activation of prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292717575613fc8c0348c18e8362a6f5
https://doi.org/10.1038/sj.mt.6300394
https://doi.org/10.1038/sj.mt.6300394
Publikováno v:
Neuroscience Research. 57:550-558
The differential characteristics of lentiviral vectors based on human and simian immunodeficiency viruses (HIV and SIV) were investigated in rats and monkeys. Each vector was injected into the striatum, and the expression patterns of the marker gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf25d954af5434f9e832d28457634c3
https://doi.org/10.1016/j.neures.2006.12.016
https://doi.org/10.1016/j.neures.2006.12.016
Autor:
Marguerite V. Evans-Galea, Arthur W. Nienhuis, Matthew M. Wielgosz, Deo Kumar Srivastava, Hideki Hanawa
Publikováno v:
Molecular Therapy. 15:801-809
Lentiviral vectors efficiently transduce quiescent stem cells and are being evaluated for gene therapy of blood dis-orders. The risk of genotoxicity as a result of insertional mutagenesis is an important safety consideration. The hy-persensitive site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::212f57972bb2360b47d18f803c0e99ff
https://doi.org/10.1038/sj.mt.6300103
https://doi.org/10.1038/sj.mt.6300103
Publikováno v:
Journal of Virology. 79:8410-8421
Permanent genetic modification of replicating primitive hematopoietic cells by an integrated vector has many potential therapeutic applications. Both oncoretroviral and lentiviral vectors have a predilection for integration into transcriptionally act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7debeb3dd187dac12086c3560f403a
https://doi.org/10.1128/jvi.79.13.8410-8421.2005
https://doi.org/10.1128/jvi.79.13.8410-8421.2005
Autor:
Deo Kumar Srivastava, Steven Kepes, Hideki Hanawa, Derek A. Persons, Phillip W. Hargrove, Arthur W. Nienhuis
Publikováno v:
Blood. 104:2281-2290
Since increased fetal hemoglobin diminishes the severity of β-thalassemia and sickle cell anemia, a strategy using autologous, stem cell–targeted gene transfer of a γ-globin gene may be therapeutically useful. We previously found that a γ-globin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6391dae0d7a2037b9dd7eb4ff2467b
https://doi.org/10.1182/blood-2004-03-0863
https://doi.org/10.1182/blood-2004-03-0863
Autor:
Thomas P. Brent, Derek A. Persons, Hideki Hanawa, Nobukuni Sawai, Arthur W. Nienhuis, Phillip W. Hargrove, Esther R. Allay, Brian P. Sorrentino
Publikováno v:
Blood. 102:506-513
Successful gene therapy of β-thalassemia will require replacement of the abnormal erythroid compartment with erythropoiesis derived from genetically corrected, autologous hematopoietic stem cells (HSCs). However, currently attainable gene transfer e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9297d9f2cd8498cd60f2bac3c354831
https://doi.org/10.1182/blood-2003-03-0677
https://doi.org/10.1182/blood-2003-03-0677