Výsledky vyhledávání - "Hideki Garren"

Akademický článek

Myelin water imaging in relapsing multiple sclerosis treated with ocrelizumab and interferon beta-1a

Autor: Shannon Kolind, Shawna Abel, Carolyn Taylor, Roger Tam, Cornelia Laule, David K.B. Li, Hideki Garren, Laura Gaetano, Corrado Bernasconi, David Clayton, Irene Vavasour, Anthony Traboulsee

Publikováno v: NeuroImage: Clinical, Vol 35, Iss , Pp 103109- (2022)

Background: Myelin water imaging is a magnetic resonance imaging (MRI) technique that quantifies myelin damage and repair in multiple sclerosis (MS) via the myelin water fraction (MWF). Objective: In this substudy of a phase 3 therapeutic trial, OPER

Externí odkaz: https://doaj.org/article/be50f8ccff20491dac691d5ad23af4ff

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Akademický článek

Transient B-cell depletion with anti-CD20 in combination with proinsulin DNA vaccine or oral insulin: immunologic effects and efficacy in NOD mice.

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e54712 (2013)

A recent type 1 diabetes (T1D) clinical trial of rituximab (a B cell-depleting anti-CD20 antibody) achieved some therapeutic benefit in preserving C-peptide for a period of approximately nine months in patients with recently diagnosed diabetes. Our p

Externí odkaz: https://doaj.org/article/de59e6efcbf84a03a25062ac99797d76

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Safety and efficacy of satralizumab monotherapy in neuromyelitis optica spectrum disorder: a randomised, double-blind, multicentre, placebo-controlled phase 3 trial

Autor: Hideki Garren, Takashi Yamamura, Padraig Wright, Lech Szczechowski, Athos Gianella-Borradori, Yuichi Kawata, Jeffrey Bennett, Edward Fox, Benjamin Greenberg, Brian G. Weinshenker, Y Terada, Svitlana Shkrobot, Anthony Traboulsee

Publikováno v: Lancet Neurol
The Lancet. Neurology, vol 19, iss 5

Summary Background Satralizumab, a humanised monoclonal antibody targeting the interleukin-6 receptor, reduced the risk of relapse in patients with neuromyelitis optica spectrum disorder (NMOSD) when added to immunosuppressant therapy. This study ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b9f9d0372da054d46618ee390dd30b
https://doi.org/10.1016/s1474-4422(20)30078-8

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Ocrelizumab efficacy in subgroups of patients with relapsing multiple sclerosis

Autor: Regine Buffels, Stephen L. Hauser, Hideki Garren, Caroline Papeix, Jian Han, Ludwig Kappos, Xavier Montalban, Benjamin Turner, Damian Fiore, Jerry S. Wolinsky, Bruce A.C. Cree

Publikováno v: Journal of Neurology. 266:1182-1193

Objective: The efficacy and safety of ocrelizumab, versus interferon (IFN) β-1a, for the treatment of relapsing multiple sclerosis (RMS) from the identically designed OPERA I (NCT01247324) and OPERA II (NCT01412333) phase III studies has been report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd74e82bcee0a54e29e4205090e821ce
https://doi.org/10.1007/s00415-019-09248-6

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Evaluation of no evidence of progression or active disease (NEPAD) in patients with primary progressive multiple sclerosis in the ORATORIO trial

Autor: Gavin Giovannoni, Jerry S. Wolinsky, Shibeshih Belachew, Hideki Garren, Gurpreet Deol-Bhullar, Peter Chin, Xavier Montalban, Patrick Vermersch, Corrado Bernasconi, Stephen L. Hauser, Ludwig Kappos

Publikováno v: Annals of Neurology. 84:527-536

Author(s): Wolinsky, Jerry S; Montalban, Xavier; Hauser, Stephen L; Giovannoni, Gavin; Vermersch, Patrick; Bernasconi, Corrado; Deol-Bhullar, Gurpreet; Garren, Hideki; Chin, Peter; Belachew, Shibeshih; Kappos, Ludwig | Abstract: ObjectiveNo evidence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adc0f212e4c4be45a4624664f72e1904
https://doi.org/10.1002/ana.25313

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Magnetic resonance spectroscopy evidence for declining gliosis in MS patients treated with ocrelizumab versus interferon beta-1a

Autor: Julia Schubert, Roger Tam, Hideki Garren, Erin L. MacMillan, Anthony Traboulsee, David Kb Li, Victoria Levesque, Alexander Rauscher, Irene M. Vavasour, Richard A. White, Carolyn Taylor, Shannon H. Kolind, David Clayton

Publikováno v: Multiple Sclerosis Journal-Experimental, Translational and Clinical

Background Magnetic resonance spectroscopy quantitatively monitors biomarkers of neuron-myelin coupling (N-acetylaspartate (NAA)), and inflammation (total creatine (tCr), total choline (tCho), myo-inositol (mI)) in the brain. Objective This study aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6081c63bcf0f902023df9586b421aac9
http://europepmc.org/articles/PMC6796216

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Activity of secukinumab, an anti-IL-17A antibody, on brain lesions in RRMS: results from a randomized, proof-of-concept study

Autor: Anne Tisserant, Ralph Paul Maguire, Alla Goloborodko, Erik Wallstroem, Anna Belova, Andrew M Wright, Eva Havrdova, Hideki Garren, Donald Johns

Publikováno v: Journal of Neurology. 263:1287-1295

The objective of this study was to assess the effect of secukinumab, a monoclonal antibody that inhibits interleukin (IL)-17A, on number of new active brain magnetic resonance imaging (MRI) lesions in subjects with relapsing-remitting multiple sclero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a171adf511f4807cfb48d18c5ef057e
https://doi.org/10.1007/s00415-016-8128-x

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Quantitative neuroimaging measures of myelin in the healthy brain and in multiple sclerosis

Autor: Jonathan, O'Muircheartaigh, Irene, Vavasour, Emil, Ljungberg, David K B, Li, Alexander, Rauscher, Victoria, Levesque, Hideki, Garren, David, Clayton, Roger, Tam, Anthony, Traboulsee, Shannon, Kolind

Publikováno v: Human Brain Mapping

Quantitative magnetic resonance imaging (MRI) techniques have been developed as imaging biomarkers, aiming to improve the specificity of MRI to underlying pathology compared to conventional weighted MRI. For assessing the integrity of white matter (W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d3b0c7a5bd4b8c9999222367bd5885ad
https://pubmed.ncbi.nlm.nih.gov/30648315

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Evolution of MS lesions to black holes under DNA vaccine treatment

Autor: Ludwig Kappos, Joanne Quan, Athina Papadopoulou, Ernst Wilhelm Radue, Robert S. King, Stefanie von Felten, Stefan Traud, Hideki Garren, Amena Rahman, Lawrence Steinman, Gary Cutter

Persistent black holes (PBH) are associated with axonal loss and disability progression in multiple sclerosis (MS). The objective of this work was to determine if BHT-3009, a DNA plasmid-encoding myelin basic protein (MBP), reduces the risk of new le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00589aad3383531c3a0096735ff1111
http://doc.rero.ch/record/317798/files/415_2011_Article_6361.pdf

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No evidence of disease activity (NEDA) analysis by epochs in patients with relapsing multiple sclerosis treated with ocrelizumab vs interferon beta-1a

Autor: Eva Havrdova, Jian Han, Iain Bennett, Shibeshih Belachew, Giancarlo Comi, Douglas L. Arnold, Gavin Giovannoni, Ludwig Kappos, Anthony Traboulsee, Fred D. Lublin, Stephen L. Hauser, Regine Buffels, Laura Julian, Krzysztof Selmaj, Julie Napieralski, Hans-Peter Hartung, Amit Bar-Or, Hideki Garren

Publikováno v: Multiple Sclerosis Journal-Experimental, Translational and Clinical
Multiple sclerosis journal-experimental, translational and clinical, vol 4, iss 1

Background No evidence of disease activity (NEDA; defined as no 12-week confirmed disability progression, no protocol-defined relapses, no new/enlarging T2 lesions and no T1 gadolinium-enhancing lesions) using a fixed-study entry baseline is commonly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4163fe9bce180cbe3804634231e6af7
http://europepmc.org/articles/PMC5858626

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