Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Hidekazu Hiroaki"'
Autor:
Hidekazu Hiroaki
Publikováno v:
Biophysics and Physicobiology, Vol 20 (2023)
To completely treat and ultimately prevent dementia, it is essential to elucidate its pathogenic mechanisms in detail. There are two major hypotheses for the pathogenesis of Alzheimer’s dementia: the β-amyloid (Aβ) hypothesis and the tau hypothes
Externí odkaz:
https://doaj.org/article/54c6feffc52241938cd8670f78ee23b4
Autor:
Koki Kataoka, Shota Suzuki, Takeshi Tenno, Natsuko Goda, Emi Hibino, Atsunori Oshima, Hidekazu Hiroaki
Publikováno v:
Current Research in Structural Biology, Vol 4, Iss , Pp 158-166 (2022)
Human stomatin (hSTOM) is a component of the membrane skeleton of erythrocytes that maintains the membrane's shape and stiffness through interconnecting spectrin and actin. hSTOM is a member of the protein family that possesses a single stomatin/proh
Externí odkaz:
https://doaj.org/article/a12eaa575f7249cd987c874e67a3d96a
Autor:
Yuri Emoto, Ryoya Katayama, Emi Hibino, Sho Ishihara, Natsuko Goda, Takeshi Tenno, Yoshihiro Kobashigawa, Hiroshi Morioka, Hidekazu Hiroaki
Publikováno v:
Methods and Protocols, Vol 6, Iss 3, p 44 (2023)
The detection and quantification of protein–protein interactions (PPIs) is a crucial technique that often involves the use of recombinant proteins with fusion protein tags, such as maltose-binding protein (MBP) and glutathione-S-transferase (GST).
Externí odkaz:
https://doaj.org/article/ff5d59e96c6b4305a66a0bee55119b82
Autor:
Mio Nakashima, Natsuko Goda, Takeshi Tenno, Ayaka Kotake, Yuko Inotsume, Minako Amaya, Hidekazu Hiroaki
Publikováno v:
Antioxidants, Vol 12, Iss 4, p 952 (2023)
The modulation of tight junction (TJ) integrity with small molecules is important for drug delivery. High-dose baicalin (BLI), baicalein (BLE), quercetin (QUE), and hesperetin (HST) have been shown to open TJs in Madin-Darby canine kidney (MDCK) II c
Externí odkaz:
https://doaj.org/article/6e35569d181240a28fd916b191c128e2
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The anti-oncogenic protein p53 is a transcription factor that prevents tumorigenesis by inducing gene repair proteins or apoptosis under DNA damage. Since the DNA-binding domain of p53 (p53C) is aggregation-prone, the anti-oncogenic function of p53 i
Externí odkaz:
https://doaj.org/article/844b465e8f704bfcb6f0f44858880459
Autor:
Takamasa Mizoguchi, Shohei Mikami, Mari Yatou, Yui Kondo, Shuhei Omaru, Shuhei Kuwabara, Wataru Okura, Syouta Noda, Takeshi Tenno, Hidekazu Hiroaki, Motoyuki Itoh
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4313 (2023)
BMP signaling is critical for many biological processes. Therefore, small molecules that modulate BMP signaling are useful for elucidating the function of BMP signaling and treating BMP signaling-related diseases. Here, we performed a phenotypic scre
Externí odkaz:
https://doaj.org/article/9b37148f20aa4cfa8d44853aca57b6be
Publikováno v:
PeerJ Physical Chemistry, Vol 3, p e20 (2021)
Background Intrinsically disordered proteins (IDPs) have been shown to exhibit cryoprotective activity toward other cellular enzymes without any obvious conserved sequence motifs. This study investigated relationships between the physical properties
Externí odkaz:
https://doaj.org/article/d2074b09e16a498baa129e09e865b83a
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2583 (2021)
Bioavailability is a major bottleneck in the clinical application of medium molecular weight therapeutics, including protein and peptide drugs. Paracellular transport of these molecules is hampered by intercellular tight junction (TJ) complexes. Ther
Externí odkaz:
https://doaj.org/article/7ef9c1275ef14f29b842f0854b51022e
Autor:
Mio Nakashima, Misaki Hisada, Natsuko Goda, Takeshi Tenno, Ayaka Kotake, Yuko Inotsume, Ikuo Kameoka, Hidekazu Hiroaki
Publikováno v:
Nutrients, Vol 12, Iss 11, p 3285 (2020)
Maintaining tight junction (TJ) integrity is important for epithelial cell barriers. Previously, the enhancement of TJ integrity, induced by citrus-derived flavonoids, naringin (NRG) and hesperidin (HSD), was demonstrated, but the effects of their ag
Externí odkaz:
https://doaj.org/article/b4adeb52d7f74c2c86d0600cb03bb320
Autor:
Kiminori Hori, Kasumi Ajioka, Natsuko Goda, Asako Shindo, Maki Takagishi, Takeshi Tenno, Hidekazu Hiroaki
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Most solid tumors have their own cancer stem cells (CSCs), which are resistant to standard chemo-therapies. Recent reports have described that Wnt pathway plays a key role in self-renewal and tumorigenesis of CSCs. Regarding the Wnt/β-catenin pathwa
Externí odkaz:
https://doaj.org/article/c473cbf1758248999b967496fe34b1ea