Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Hidekazu, Mizuhara"'
Autor:
Fujiko Takamura, Erik E. Karrer, Yasuyuki Higashi, Steven J. Chapin, Margaret Neighbors, Sridhar Viswanathan, Hidekazu Mizuhara, Shinsuke Oshima, Yasutomo Fujii, Bruce H. Devens
Publikováno v:
International Immunopharmacology. 40:310-317
The CTLA4-Ig fusion proteins abatacept and belatacept inhibit CD28-mediated T cell activation by binding CD80 (B7-1) and CD86 (B7-2) costimulatory ligands and are clinically proven immunosuppressants used for rheumatoid arthritis and renal transplant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ff00ad001bd419bd264871d2b736f8
https://doi.org/10.1016/j.intimp.2016.09.009
https://doi.org/10.1016/j.intimp.2016.09.009
Autor:
Masaomi Terajima, Naoto Nakamura, Masatoshi Yuri, Kazuyuki Hattori, Masanori Naitou, Masashi Hiramoto, Yasuyuki Higashi, Hiroyuki Yokota, Hidekazu Mizuhara, Yoko Kaneko-Kobayashi
Publikováno v:
European journal of pharmacology. 780
Aberrant production of proinflammatory cytokines is linked to many autoimmune diseases, and their inhibition by small molecule compounds is considered beneficial. Here, we performed phenotypic screening in IFNγ/LPS-activated RAW264.7, mouse macropha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d097efa4f5a564266c766bbec5704be
https://pubmed.ncbi.nlm.nih.gov/27001378
https://pubmed.ncbi.nlm.nih.gov/27001378
Autor:
Hidekazu Mizuhara, Mizuko Mamura, Ethan M. Shevach, John J. Letterio, Angela M. Thornton, Rebecca S. McHugh, Ciriaco A. Piccirillo
Publikováno v:
The Journal of Experimental Medicine
CD4(+)CD25(+) regulatory T cells inhibit organ-specific autoimmune diseases induced by CD4(+)CD25(-) T cells and are potent suppressors of T cell activation in vitro. Their mechanism of suppression remains unknown, but most in vitro studies suggest t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c52e6ee1c3ca8d42ac3305d0edad37e2
https://doi.org/10.1084/jem.20020590
https://doi.org/10.1084/jem.20020590
Publikováno v:
Hepatology. 27:497-506
Concanavalin A (Con A) stimulation induces T-cell activation-associated hepatic injury. This study is designed to show the involvement of microcirculatory disturbance in the pathogenesis. Con A administration led to prominent intrasinusoidal hemostas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31cbbd44c0ffa4295520fc4b80a31926
https://doi.org/10.1002/hep.510270225
https://doi.org/10.1002/hep.510270225
Publikováno v:
Biomedical Research. 17:129-139
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::285ea370749be39804ca9cb89c3792be
https://doi.org/10.2220/biomedres.17.129
https://doi.org/10.2220/biomedres.17.129
Autor:
Tatsuo Inoue, Katsue Magari, Hidekazu Mizuhara, Hitoshi Yamazaki, Masaomi Terajima, Yasuyuki Higashi
Publikováno v:
European journal of pharmacology. 698(1-3)
Given the key role p38 mitogen-activated protein kinase (MAPK) plays in inflammatory responses through the production of cytokines and inflammatory mediators, its inhibition is considered a promising therapeutic strategy for chronic inflammatory dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fedc6e6b8307527dfe438fecd44f21f0
https://pubmed.ncbi.nlm.nih.gov/23183108
https://pubmed.ncbi.nlm.nih.gov/23183108
Autor:
Susumu Satoh, Hachiro Senoh, Elaine O'Neill, Hiromi Fujiwara, Hidekazu Mizuhara, Chihiro Kusunoki, Kazuyuki Otsuka, Toshikazu Ogawa, Mineo Niwa, Nobuo Seki
Publikováno v:
The Journal of Experimental Medicine
This study investigates the molecular mechanisms underlying the induction of and protection from T cell activation-associated hepatic injury. When BALB/c mice were given a single intravenous injection of concanavalin A (Con A) (> or = 0.3 mg/mouse),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789427229616e3d3496c83fcd9420ac7
https://doi.org/10.1084/jem.179.5.1529
https://doi.org/10.1084/jem.179.5.1529
Autor:
Takeshi, Inoue, Haruo, Horiai, Chizuru, Aoki, Ikuo, Kawamura, Mariko, Ota, Hidekazu, Mizuhara, Masaaki, Tomoi, Seitaro, Mutoh
Publikováno v:
In vivo (Athens, Greece). 17(3)
The aim of this study was to evaluate the effect of insulin-like growth factor-I (IGF-I) on lethality and liver function in experimental acute liver failure. Intravenous co-administration of D-galactosamine (GalN) and lipopolysaccharide (LPS) to rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d246852b6d487ac0fec4ac44ef66e77b
https://pubmed.ncbi.nlm.nih.gov/12929583
https://pubmed.ncbi.nlm.nih.gov/12929583
Autor:
E. Imamura, Hidekazu Mizuhara, Y. Kaneko-Kobayashi, Masatoshi Yuri, Masaomi Terajima, Yasuyuki Higashi, Kazuyuki Hattori, T. Ishikawa, N. Seki, Naoto Nakamura
Publikováno v:
Annals of the Rheumatic Diseases. 73:370.1-370
Background Aberrant production of proinflammatory cytokines is associated with various chronic inflammatory diseases, and their functional inhibition is considered beneficial. We previously reported the discovery of novel small molecule inhibitors of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71dc7ddd60bd0bc3b2edb9fb9613d53b
https://doi.org/10.1136/annrheumdis-2014-eular.1310
https://doi.org/10.1136/annrheumdis-2014-eular.1310
Autor:
Kenji Kaneda, Hidekazu Mizuhara, Hiromi Fujiwara, Kazutaka Hachiya, Tetsuo Kuroki, Susumu Shiomi, Hiroyasu Morikawa, Shuhei Nishiguchi
Publikováno v:
Hepatology (Baltimore, Md.). 31(1)
Lymphocyte infiltration is a manifest feature of hepatitis. To reveal the main site and mechanism of lymphocyte adhesion/extravasation in the hepatic vasculature during inflammation, we morphometrically and histologically analyzed these events in rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858207067504f4037fbd3fa5280e5859
https://pubmed.ncbi.nlm.nih.gov/10613732
https://pubmed.ncbi.nlm.nih.gov/10613732