Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Hidehiro Ishikawa"'
Autor:
Tomonori Hoshino, Hajime Takase, Hidehiro Ishikawa, Gen Hamanaka, Shintaro Kimura, Norito Fukuda, Ji Hyun Park, Hiroki Nakajima, Hisashi Shirakawa, Akihiro Shindo, Kyu-Won Kim, Irwin H Gelman, Josephine Lok, Ken Arai
Publikováno v:
Bioinformatics and Biology Insights, Vol 18 (2024)
A-kinase anchor protein 12 (AKAP12), a scaffold protein, has been implicated in the central nervous system, including blood-brain barrier (BBB) function. Although its expression level in the corpus callosum is higher than in other brain regions, such
Externí odkaz:
https://doaj.org/article/1fd76de251144c16af1a0bf481a6830d
Autor:
Kana Matsuda, Masaki Shinohara, Yuichiro Ii, Ken-ichi Tabei, Yukito Ueda, Naoko Nakamura, Yoshinori Hirata, Hidehiro Ishikawa, Hirofumi Matsuyama, Keita Matsuura, Masayuki Satoh, Masayuki Maeda, Ryo Momosaki, Hidekazu Tomimoto, Akihiro Shindo
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
ObjectiveThe severity of cerebral small vessel disease (SVD) on magnetic resonance imaging (MRI) has been assessed using hypertensive arteriopathy SVD and cerebral amyloid angiopathy (CAA)-SVD scores. In addition, we reported the modified CAA-SVD sco
Externí odkaz:
https://doaj.org/article/fb47a5cca764440eb0693ac76a8d38ef
Autor:
Paul Shin, Qi Pian, Hidehiro Ishikawa, Gen Hamanaka, Emiri T Mandeville, Shuzhen Guo, Buyin Fu, Mohammed Alfadhel, Srinivasa Rao Allu, Ikbal Şencan-Eğilmez, Baoqiang Li, Chongzhao Ran, Sergei A Vinogradov, Cenk Ayata, Eng Lo, Ken Arai, Anna Devor, Sava Sakadžić
Publikováno v:
eLife, Vol 12 (2023)
Aging is a major risk factor for cognitive impairment. Aerobic exercise benefits brain function and may promote cognitive health in older adults. However, underlying biological mechanisms across cerebral gray and white matter are poorly understood. S
Externí odkaz:
https://doaj.org/article/d8dab7b93098434d9bd1a2eff89efcd1
Autor:
Masaki Shinohara, Kana Matsuda, Yuichiro Ii, Ken-ichi Tabei, Naoko Nakamura, Yoshinori Hirata, Hidehiro Ishikawa, Hirofumi Matsuyama, Keita Matsuura, Masayuki Maeda, Hidekazu Tomimoto, Akihiro Shindo
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
ObjectivesCerebral small vessel disease (SVD) is commonly observed among elderly individuals with cognitive impairment and has been recognized as a vascular contributor to dementia and behavioral and psychological symptoms (BPS), however, the relatio
Externí odkaz:
https://doaj.org/article/fe9de257fd7d4b558ff691688b762179
Autor:
Yamato Nishiguchi, Keita Matsuura, Yoshinori Hirata, Akane Mizutani, Natsuko Katoh, Hidehiro Ishikawa, Koichi Miyashita, Takaya Utsunomiya, Hiroyuki Kajikawa, Hirofumi Nishikawa, Tomohiro Araki, Akihiro Shindo, Hidekazu Tomimoto
Publikováno v:
Heliyon, Vol 8, Iss 2, Pp e08900- (2022)
Background: Some patients with Parkinson's disease (PD) develop peri-lead brain edema after deep brain stimulation (DBS) surgery. The influence of edema on neurological function is not well characterized. We investigated the relationship of brain ede
Externí odkaz:
https://doaj.org/article/0142fbb189b94c61a75dea6399ea4ba8
Autor:
Shoko Sakano, Hirofumi Matsuyama, Hidehiro Ishikawa, Akihiro Shindo, Yuichiro Ii, Keita Matsuura, Minoru Mizutani, Norikazu Kawada, Hidekazu Tomimoto
Publikováno v:
BMC Neurology, Vol 20, Iss 1, Pp 1-4 (2020)
Abstract Background The onset of myasthenia (MG) gravis with anti-muscle-specific tyrosine kinase (MuSK) antibodies most commonly peaks in the fourth decade of life, and MG with MuSK antibodies (MuSK-MG) rarely coexists with a malignant tumor. To dat
Externí odkaz:
https://doaj.org/article/a7f10a71ed9646a992b6c802be3ab317
Autor:
Hidehiro Ishikawa, Akihiro Shindo, Yuichiro Ii, Dai Kishida, Atsushi Niwa, Yamato Nishiguchi, Keita Matsuura, Natsuko Kato, Akane Mizutani, Kei Tachibana, Yoshinori Hirata, Hirofumi Matsuyama, Ai Ogawa‐Ito, Akira Taniguchi, Hidekazu Tomimoto
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 12, Pp 2595-2600 (2019)
Abstract Mediterranean fever (MEFV) gene mutations are associated with familial Mediterranean fever (FMF). Recent studies have suggested that MEFV gene mutations may act as disease modifiers in neuro‐Behçet's (NBD) disease and neuro‐Sweet diseas
Externí odkaz:
https://doaj.org/article/07142c8911924b4ab0967f18a015d68e
Autor:
Ryo Ohtomo, Hidehiro Ishikawa, Keita Kinoshita, Kelly K. Chung, Gen Hamanaka, Gaku Ohtomo, Hajime Takase, Christiane D. Wrann, Hiroshi Katsuki, Atsushi Iwata, Josephine Lok, Eng H. Lo, Ken Arai
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Clinical and basic research suggests that exercise is a safe behavioral intervention and is effective for improving cognitive function in cerebrovascular diseases, including subcortical ischemic vascular dementia (SIVD). However, most of the basic re
Externí odkaz:
https://doaj.org/article/9edc09523ab84bf68816a3ad42d52779
Autor:
Hajime Takase, Gen Hamanaka, Ryo Ohtomo, Hidehiro Ishikawa, Kelly K. Chung, Emiri T. Mandeville, Josephine Lok, Myriam Fornage, Karl Herrup, Kai-Hei Tse, Eng H. Lo, Ken Arai
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
White matter damage caused by cerebral hypoperfusion is a major hallmark of subcortical ischemic vascular dementia (SIVD), which is the most common subtype of vascular cognitive impairment and dementia (VCID) syndrome. In an aging society, the number
Externí odkaz:
https://doaj.org/article/25f21b31cb26423c8c40c5188442765d
Autor:
Hidekazu Tomimoto, Takayuki Kondo, Yoshihide Sunada, Hidehiro Ishikawa, Akihiro Shindo, Yuishin Izumi, Haruhiko Banno, Satoshi Morita, Koji Fujita, Ryosuke Takahashi, Haruhisa Inoue, Takakuni Maki, Toshifumi Watanabe, Kenji Ishii, Manabu Ikeda, Taro Okunomiya, Yoko Amino, Kayoko Endo, Akiyoshi Nakakura, Akemi Kinoshita, Harue Tada, Ken Yasuda, Yosuke Taruno, Takashi Suehiro, Kohji Mori, Kazutomi Kanemaru, Kazue Shigenobu, Yumiko Kutoku, Shinobu Kawakatsu, Shunji Shiota, Osamu Uchikawa
Publikováno v:
BMJ Open, Vol 11, Iss 6 (2021)
Introduction Alzheimer’s disease (AD) is one of the most common causes of dementia. Pathogenic variants in the presenilin 1 (PSEN1) gene are the most frequent cause of early-onset AD. Medications for patients with AD bearing PSEN1 mutation (PSEN1-A
Externí odkaz:
https://doaj.org/article/5a95f19b8f854322a9c17d2f1445538b