Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Hidehiko Kodama"'
Autor:
Yasunobu Yamashita, Takayoshi Suzuki, Yoshinori Suzuma, Remy Narozny, Shusaku Uchida, Yuka Miyake, Yukihiro Itoh, Hidehiko Kodama, Takashi Kurohara, Yutaro Hanatani
Publikováno v:
ACS Catalysis. 10:5383-5392
In situ click chemistry has great potential for identifying enzyme inhibitors. However, conventional in situ click chemistry provides extremely low yields of the products, making it incompatible wi...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f217ce3b88e39359f78215ba3615e36a
https://doi.org/10.1021/acscatal.0c00369
https://doi.org/10.1021/acscatal.0c00369
Autor:
Tetsuo Nakabayashi, Akihisa Maeda, Takashi Dan, Kenji Murano, Nagahisa Yamaoka, Toshio Miyata, Hidehiko Kodama, Kanji Meguro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:809-813
Novel plasminogen activator inhibitor-1 (PAI-1) inhibitors with highly improved oral bioavailability were discovered by structure-activity relationship studies on N-acyl-5-chloroanthranilic acid derivatives. Because lipophilic N-acyl groups seemed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3839236b25a26fdf28dc0b6693b114bb
https://doi.org/10.1016/j.bmcl.2017.11.016
https://doi.org/10.1016/j.bmcl.2017.11.016
Publikováno v:
Letters in Organic Chemistry. 4:530-534
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15b7da81085df5554e4c1774591d1c72
https://doi.org/10.2174/157017807782795493
https://doi.org/10.2174/157017807782795493
Autor:
Yoshihiro Hayakawa, Rie Kawai, Mamoru Hyodo, Hidehiko Kodama, Dong-Mei Cui, Yoshiko Hirabayashi, Tomoyuki Matsunami, Satoko Yamashita
Publikováno v:
European Journal of Organic Chemistry. 2006:3834-3844
This paper describes a new method for the highly stereoselective preparation of dithymidine phosphorothioates (TpsT) with the (R) or the (S) configuration at the stereogenic phosphorus atom [(Rp)- or (Sp)-TpsT, respectively], together with the synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05fbeda95d094c29424258c85511b0fc
https://doi.org/10.1002/ejoc.200600155
https://doi.org/10.1002/ejoc.200600155
Publikováno v:
Bioorganicmedicinal chemistry. 22(14)
Histone deacetylase (HDAC) inhibitions are known to elicit anticancer effects. We designed and synthesized several HDAC inhibitors. Among these compounds, compound 40 exhibited a more than 10-fold stronger inhibitory activity compared with that of su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0926b069e17f845291e866b995cbae66
https://pubmed.ncbi.nlm.nih.gov/24864038
https://pubmed.ncbi.nlm.nih.gov/24864038
Publikováno v:
Tetrahedron: Asymmetry. 11:4009-4015
The asymmetric allylic alkylation of rac -1,3-diphenyl-2-propenyl acetate 1 with dimethyl malonate 2a proceeded smoothly in the presence of lithium acetate, BSA ( N , O -bis(trimethylsilyl)acetamide), [Pd(η 3 -C 3 H 5 )Cl] 2 , and the chiral ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b4af7380e70b778851d775484e7421b
https://doi.org/10.1016/s0957-4166(00)00370-0
https://doi.org/10.1016/s0957-4166(00)00370-0
Publikováno v:
Journal of Organometallic Chemistry. 603:6-12
New BINOL-derived ligands, 3,3′-bis(2-oxazolyl)-1,1′-bi-2-naphthols (BINOL-Box), bearing chiral bis-oxazoline at the 3,3′-carbons, were synthesized from commercially available 1,1′-bi-2-naphthol (BINOL). With the new ligands obtained, we foun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1853af4dc1c617461ee962098fcbd418
https://doi.org/10.1016/s0022-328x(00)00024-3
https://doi.org/10.1016/s0022-328x(00)00024-3
Publikováno v:
Applied Organometallic Chemistry. 14:709-714
With 3,3'-bis(2-oxazolyl)-1,1'-bi-2-naphthols (BINOL-Box) synthesized from 1,1'-bi-2-naphthol (BINOL), the enantioselective addition of diethylzinc to aryl aldehydes proceeded smoothly to give secondary aryl alcohols in good yield with good enantiose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b15910a925834bdd5b8984d8a1c2f6f4
https://doi.org/10.1002/1099-0739(200011)14:11<709::aid-aoc60>3.0.co
https://doi.org/10.1002/1099-0739(200011)14:11<709::aid-aoc60>3.0.co
Publikováno v:
The Journal of Organic Chemistry. 64:5017-5023
Chiral phosphinepalladium(II)-catalyzed asymmetric 1,3-dipolar cycloaddition of nitrones to α,β-unsaturated carboxylic acid derivatives has been investigated. In the presence of a catalytic amount of [Pd(NCMe)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d25b49fb4afa46bbbf588ebca146b3
https://doi.org/10.1021/jo981483g
https://doi.org/10.1021/jo981483g
Publikováno v:
Tetrahedron Letters. 37:5947-5950
Asymmetric 1,3-dipolar cycloaddition of nitrone 2 to olefin 1 was catalyzed by chiral phosphine - palladium complexes to give isoxazolidine 3 in high yield with high enantioselectivity up to 91% ee.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dcfe0f1a35db6777b8a59d743a2b2e6
https://doi.org/10.1016/0040-4039(96)01284-1
https://doi.org/10.1016/0040-4039(96)01284-1