Výsledky vyhledávání - "Hideharu Odai"

Isohumulones, Bitter Acids Derived from Hops, Activate Both Peroxisome Proliferator-activated Receptor α and γ and Reduce Insulin Resistance

Autor: Osamu Ezaki, Shinichi Oikawa, Maho Shiraki, Tomoka Kanaya, Emiko Ikeshima, Nobuyo Tsuboyama-Kasaoka, Hiroaki Yajima, Hideharu Odai, Daisuke Fujiwara, Keiji Kondo

Publikováno v: Journal of Biological Chemistry. 279:33456-33462

The peroxisome proliferator-activated receptors (PPARs) are dietary lipid sensors that regulate fatty acid and carbohydrate metabolism. The hypolipidemic effects of fibrate drugs and the therapeutic benefits of the thiazolidinedione drugs are due to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc58a7f828d3e66401d87157cd5a8ad8
https://doi.org/10.1074/jbc.m403456200

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Tyrosine Phosphorylation of a 94-kDa Protein Associated with GRB2/ASH Is Implicated in the Signal Transduction of Hematopoietic Survival Factors

Autor: Hisamaru Hirai, Hideharu Odai, Yutaka Hanazono, Ko Sasaki, Yoshio Yazaki

Publikováno v: Biochemical and Biophysical Research Communications. 222:330-337

Grb2/Ash is an adapter molecule that contains Src-homology (SH) 2 and 3 domains. We have examined Grb2/Ash-associated proteins in hematopoietic cells, and have noted a 94-kDa phosphotyrosine-containing protein (pp94) among them. It was shown that the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab5c9a7f4316bc85d430b90947d12e6
https://doi.org/10.1006/bbrc.1996.0744

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Proto-Oncogene Products Vav and c-Cbl Are Involved in the Signal Transduction through Grb2/Ash in Hematopoietic Cells

Autor: Hisamaru Hirai, Akihiro Iwamatsu, Yutaka Hanazono, Yoshio Yazaki, Ko Sasaki, Hideharu Odai

Publikováno v: Acta Haematologica. 95:236-242

Grb2/Ash is composed of one SH2 and two SH3 domains and functions as an adapter linking tyrosine kinase receptors and Ras in fibroblasts. We have investigated the nature of proteins interacting with Grb2/Ash in hematopoietic cells. The product of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0564124671351db912013aeb3ed8cf19
https://doi.org/10.1159/000203884

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The Proto-oncogene Product c-Cbl Becomes Tyrosine Phosphorylated by Stimulation with GM-CSF or Epo and Constitutively Binds to the SH3 Domain of Grb2/Ash in Human Hematopoietic Cells

Autor: Kinuko Mitani, Ko Sasaki, Hisamaru Hirai, Akihiro Iwamatsu, Y. Yazaki, Tomoyuki Tanaka, Yutaka Hanazono, Hideharu Odai

Publikováno v: Journal of Biological Chemistry. 270:10800-10805

Granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin (Epo) are hematopoietic growth factors that regulate proliferation and differentiation of hematopoietic cells. They elicit and control a cascade of biochemical events, the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67525de14a626ccf404f91b87e039cbd
https://doi.org/10.1074/jbc.270.18.10800

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Tyrosine Phosphorylation of the Proto‐oncogene Product Vav and Its Association with the Adapter Grb2/Ash in a Human Leukemia Cell Line UT‐7

Autor: Hisamaru Hirai, Yutaka Hanazono, Kinuko Mitani, Hideharu Odai, Ko Sasaki, Toshihide Mimura, Y. Yazaki

Publikováno v: Japanese Journal of Cancer Research : Gann

The vav proto-oncogene product (Vav) is expressed exclusively in hematopoietic cells and is reported to have guanine nucleotide exchange activity. Here we report that granulocyte-macrophage colony-stimulating factor, interleukin-3, and erythropoietin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e71970ca73ef1df5535b96e9a74a346
http://europepmc.org/articles/PMC5920837

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Design and synthesis of Rho kinase inhibitors (II)

Autor: Atsuya Takami, Mutsuki Amano, Kaname Kimura, Hiroshi Iijima, Kayoko Fukushima, Yuji Okada, Kazutoshi Shindo, Takehisa Kawata, Nobuaki Takahashi, Masayuki Iwakubo, Masaki Inagaki, Yoshimichi Tagami, Hideharu Odai, Kozo Kaibuchi, Mika Miyake

Publikováno v: Bioorganicmedicinal chemistry. 15(1)

In a previous study, we identified several structurally unrelated scaffolds of the Rho kinase inhibitor using pharmacophore information obtained from the results of a high-throughput screening and structural information from a homology model of Rho k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::918428a64372154dc7d70e000e7bdb88
https://pubmed.ncbi.nlm.nih.gov/17046269

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Dietary isohumulones, the bitter components of beer, raise plasma HDL-cholesterol levels and reduce liver cholesterol and triacylglycerol contents similar to PPARalpha activations in C57BL/6 mice

Autor: Chiaki Oyamada, Keiji Kondo, Hideharu Odai, Mayu Hosono, Yutaka Miura, Shinichi Oikawa

Publikováno v: The British journal of nutrition. 93(4)

The effects of dietary isohumulones, the main components accounting for the bitter taste of beer, on lipid metabolism were examined. Young female C57BL/6N mice were fed diets containing isomerized hop extract (IHE), which consists mainly of isohumulo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2cd6b9a16d19166265f4c10b170d40
https://pubmed.ncbi.nlm.nih.gov/15946420

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Design and synthesis of Rho kinase inhibitors (I)

Autor: Atsuya Takami, Masayuki Iwakubo, Yuji Okada, Takehisa Kawata, Hideharu Odai, Nobuaki Takahashi, Kazutoshi Shindo, Kaname Kimura, Yoshimichi Tagami, Mika Miyake, Kayoko Fukushima, Masaki Inagaki, Mutsuki Amano, Kozo Kaibuchi, Hiroshi Iijima

Publikováno v: Bioorganicmedicinal chemistry. 12(9)

Several structurally unrelated scaffolds of the Rho kinase inhibitor were designed using pharmacophore information obtained from the results of a high-throughput screening and structural information from a homology model of Rho kinase. A docking simu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf2bc3d099e654a30d0f7c1271a5772
https://pubmed.ncbi.nlm.nih.gov/15080913

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Specific accumulation of Rho-associated kinase at the cleavage furrow during cytokinesis: cleavage furrow-specific phosphorylation of intermediate filaments

Autor: Yasuko Tomono, Masatoshi Fujita, Hidetaka Kosako, Kaori Matsuzawa, Hidemasa Goto, Masaki Inagaki, Kozo Kaibuchi, Maki Yanagida, Hideharu Odai, Tohru Okigaki

Publikováno v: Oncogene. 18(17)

The small GTPase Rho and one of its targets, Rho-associated kinase (Rho-kinase), are implicated in a wide spectrum of cellular functions, including cytoskeletal rearrangements, transcriptional activation and smooth muscle contraction. Since Rho also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3bee84b7534e48863d9f474162016b6
https://pubmed.ncbi.nlm.nih.gov/10348354

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