Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Hidefumi, Yoshinaga"'
1
Discovery of DSP-1053, a novel benzylpiperidine derivative with potent serotonin transporter inhibitory activity and partial 5-HT1A receptor agonistic activity
Autor: Hidefumi Yoshinaga, Kazuki Yabuuchi, Tomohiro Toyoda, Tomoaki Nishida, Sasaki Izumi, Taro Kato, Hitomi Oki
Publikováno v: Bioorganic & Medicinal Chemistry. 26:1614-1627
We have previously shown that SMP-304, a serotonin uptake inhibitor with weak 5-HT1A partial agonistic activity, may act under high serotonin levels as a 5-HT1A antagonist that improves the onset of paroxetine in the rat swimming test. However, SMP-3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4708acf52f4efbca269149332918fe37
https://doi.org/10.1016/j.bmc.2018.02.008
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2
Discovery of SMP-304, a novel benzylpiperidine derivative with serotonin transporter inhibitory activity and 5-HT1A weak partial agonistic activity showing the antidepressant-like effect
Autor: Hitomi Oki, Satoko Baba, Naoya Kinomura, Tomoko Horisawa, Yuji Matsumoto, Shuji Masumoto, Toru Kodo, Hidefumi Yoshinaga, Kazuki Yabuuchi, Kenji Matsumoto, Koji Koyama, Taro Kato
Publikováno v: Bioorganic & Medicinal Chemistry. 25:293-304
We report the discovery of a novel benzylpiperidine derivative with serotonin transporter (SERT) inhibitory activity and 5-HT1A receptor weak partial agonistic activity showing the antidepressant-like effect. The 3-methoxyphenyl group and the pheneth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ba769b17a416f9ae21de763c79ea557
https://doi.org/10.1016/j.bmc.2016.10.034
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5
First- and Second-Generation Practical Syntheses of Chroman-4-one Derivative: A Key Intermediate for the Preparation of SERT/5-HT1A Dual Inhibitors
Autor: Tomohiro Toyoda, Minoru Toshima, Hidefumi Yoshinaga, Tomoaki Nishida
Publikováno v: Organic Process Research & Development. 16:625-634
Two approaches to large-scale synthesis of the key intermediate 9, a precursor of novel dual inhibitors of SERT/5-HT1A receptor, are described. These two approaches each feature a mild and efficient method for construction of the chroman-4-one scaffo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80ec90534154ac8c2a77fa8c79d34a4c
https://doi.org/10.1021/op200357h
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6
Unexpected reactions of ferrocene acetal derived from tartaric acid with alkyllithium: competition between proton abstraction and nucleophilic attack
Autor: Yohji Nakatsuji, Hidefumi Yoshinaga, Wanbin Zhang, Isao Ikeda, Fang Xie, Toshiyuki Kida
Publikováno v: Tetrahedron. 62:9038-9042
We wished to prepare planar chiral compounds by the lithiation of acetal 2-ferrocenyl-(4S,5S)-bis(methoxymethyl)-1,3-dioxolane (1) with butyllithium followed by the reaction with an electrophile. However, the desired products were not observed and tw
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39827b1375070bd02daf0b4baca5aaa9
https://doi.org/10.1016/j.tet.2006.07.001
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7
A Novel Axially Chiral Phosphine-Oxazoline Ligand with an Axis-Unfixed Biphenyl Backbone: Preparation, Complexation, and Application in an ­Asymmetric Catalytic Reaction
Autor: Wanbin Zhang, Toshiyuki Kida, Fang Xie, Hidefumi Yoshinaga, Isao Ikeda, Yohji Nakatsuji
Publikováno v: Synlett. 2006:1185-1188
A novel chiral phosphine-oxazoline ligand 3 with an axis-unfixed biphenyl backbone was prepared. This ligand existed as a mixture of two diastereomers in equilibrium in solution. However, when it was coordinated with palladium(II), only one of the tw
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1223d1d99bde2aa9e96689d67c2757c
https://doi.org/10.1055/s-2006-933100
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