Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Hideaki Nanamiya"'
Identification and clinical significance of somatic oncogenic mutations in epithelial ovarian cancer
Autor:
Takafumi Watanabe, Hideaki Nanamiya, Yuta Endo, Manabu Kojima, Shinji Nomura, Shigenori Furukawa, Shu Soeda, Hirosumi Tamura, Masae Ryufuku, Daisuke Tanaka, Takao Isogai, Jun-ichi Imai, Shinya Watanabe, Keiya Fujimori
Publikováno v:
Journal of Ovarian Research, Vol 14, Iss 1, Pp 1-9 (2021)
Abstract Objective Epithelial ovarian cancer (EOC) is a heterogeneous disease with diverse clinicopathological features and behaviors, and its heterogeneity may be concerned with the accumulation of multiple somatic oncogenic mutations. The major goa
Externí odkaz:
https://doaj.org/article/8cce3126c5654d118cdfe764c677a547
Autor:
Takafumi Watanabe, Hideaki Nanamiya, Manabu Kojima, Shinji Nomura, Shigenori Furukawa, Shu Soeda, Daisuke Tanaka, Takao Isogai, Jun-ichi Imai, Shinya Watanabe, Keiya Fujimori
Publikováno v:
Translational Oncology, Vol 14, Iss 3, Pp 101010- (2021)
Purpose: Endometrial carcinoma (EC) is a clinically heterogeneous disease characterized by a number of different histological subtypes, and its heterogeneity may be involved in the accumulation of multiple genetic alterations. The aim of this work wa
Externí odkaz:
https://doaj.org/article/6e9d2023c9a24746890cdc0b784eac06
Identification and clinical significance of somatic oncogenic mutations in epithelial ovarian cancer
Autor:
Keiya Fujimori, Jun-ichi Imai, Takafumi Watanabe, Hirosumi Tamura, Masae Ryufuku, Daisuke Tanaka, Yuta Endo, Shigenori Furukawa, Takao Isogai, Shu Soeda, Shinji Nomura, Shinya Watanabe, Hideaki Nanamiya, Manabu Kojima
Publikováno v:
Journal of Ovarian Research
Journal of Ovarian Research, Vol 14, Iss 1, Pp 1-9 (2021)
Journal of Ovarian Research, Vol 14, Iss 1, Pp 1-9 (2021)
Objective Epithelial ovarian cancer (EOC) is a heterogeneous disease with diverse clinicopathological features and behaviors, and its heterogeneity may be concerned with the accumulation of multiple somatic oncogenic mutations. The major goals of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e59b6e1095ff0deecdc2747e06312d
https://doi.org/10.1186/s13048-021-00876-z
https://doi.org/10.1186/s13048-021-00876-z
Autor:
Hideaki Nanamiya, Hirofumi Yoshikawa, Taku Chibazakura, Fumiya Okawa, Akiko Soma, Satoru Watanabe, Genki Akanuma, Yousuke Natori, Yasuyuki Kato-Yamada, Masaki Watanabe, Kei Asai, Fujio Kawamura, Takashi Hishida
Publikováno v:
J Bacteriol
Ribosomal protein S14 can be classified into three types. The first, the C+ type has a Zn2+ binding motif and is ancestral. The second and third are the C− short and C− long types, neither of which contain a Zn2+ binding motif and which are ca. 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a62da04816e94f087256eaf6daabc5
https://doi.org/10.1128/jb.00599-20
https://doi.org/10.1128/jb.00599-20
Autor:
Satoshi Muto, Hiroyuki Suzuki, Hikaru Yamaguchi, Takeo Hasegawa, Yuki Ozaki, Yuki Matsumura, Takao Isogai, Mitsunori Higuchi, Mika Hoshino, Mitsuro Fukuhara, Takumi Yamaura, Jun-ichi Imai, Masayuki Watanabe, Shinya Watanabe, Hideaki Nanamiya, Hayato Mine, Jun Osugi, Takuya Inoue, Hironori Takagi, Yutaka Shio, Naoyuki Okabe
Publikováno v:
Oncology Letters
β-catenin expression by tumor cells suppressed dendritic cell recruitment to the tumor microenvironment in a melanoma model, resulting in fewer tumor-infiltrating lymphocytes. Immunohistochemistry was used in the present study to examine the associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b8a3396a5fc226b40c9878fd3b31d8
https://doi.org/10.3892/ol.2021.12464
https://doi.org/10.3892/ol.2021.12464
Autor:
Shigenori Furukawa, Keiya Fujimori, Jun-ichi Imai, Takafumi Watanabe, Hideaki Nanamiya, Shu Soeda, Shinji Nomura, Manabu Kojima, Shinya Watanabe, Daisuke Tanaka, Takao Isogai
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
It is well known that tumour initiation and progression are primarily an accumulation of genetic mutations. The mutation status of a tumour may predict prognosis and enable better selection of targeted therapies. In the current study, we analysed a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b2e3e1e72ae6a7a5c769f8ecfcc662
http://europepmc.org/articles/PMC7599240
http://europepmc.org/articles/PMC7599240
Autor:
Mitsuro Fukuhara, Jun Ohsugi, Yuki Matsumura, Takeo Hasegawa, Hiroyuki Suzuki, Takao Isogai, Yuzuru Watanabe, Yuki Owada-Ozaki, Hironori Takagi, Satoshi Muto, Shinya Watanabe, Hideaki Nanamiya, Mika Hoshino, Jun-ichi Imai, Takuya Inoue, Takumi Yamaura, Naoyuki Okabe, Yutaka Shio
Publikováno v:
Journal of Thoracic Oncology. 13:1217-1221
Introduction Tumor mutation burden (TMB) is thought to be associated with the amount of neoantigen in the tumor and to have an important role in predicting the effect of immune checkpoint inhibitors. However, the relevance of TMB to prognosis is not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0e493c47cf38fb9978f1391a97a0e4
https://doi.org/10.1016/j.jtho.2018.04.003
https://doi.org/10.1016/j.jtho.2018.04.003
BackgroundThe structural abnormalities in chromosomes are important issues in cancer genomics. Next generation sequencing technologies have big potentials to detect the structural variations precisely and comprehensively. Nevertheless, it is still di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f082714bbcde914754ecc825a32b66
Autor:
Daisuke Tanaka, Shu Soeda, Takafumi Watanabe, Keiya Fujimori, Takao Isogai, Jun-ichi Imai, Shigenori Furukawa, Hideaki Nanamiya, Manabu Kojima, Shinya Watanabe, Shinji Nomura
Publikováno v:
Translational Oncology
Translational Oncology, Vol 14, Iss 3, Pp 101010-(2021)
Translational Oncology, Vol 14, Iss 3, Pp 101010-(2021)
Highlights • Comprehensive somatic mutations profiling in endometrial carcinoma. • Relationships between somatic mutations and clinicopathological characteristics. • Relatiohship between FBXW7 mutation and vascular invasion in endometrial carci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a49786e68769f3bd6f56be5b723697
https://doi.org/10.1016/j.tranon.2021.101010
https://doi.org/10.1016/j.tranon.2021.101010
Autor:
Jun-ichi Imai, Yuki Ozaki, Takumi Yamaura, Takeo Hasegawa, Hideaki Nanamiya, Naoyuki Okabe, Hironori Takagi, Hiroyuki Suzuki, Takuya Inoue, Mitsuro Fukuhara, Daisuke Tanaka, Takao Isogai, Yutaka Shio, Yuki Matsumura, Mika Hoshino, Jun Ohsugi, Masayuki Watanabe, Shinya Watanabe, Satoshi Muto
Publikováno v:
Cancer immunology, immunotherapy : CII. 69(1)
Cancer treatment using immune checkpoint inhibitors is widely used, although biomarkers predictive of response are not well established. However, both the expressions of programmed cell death ligand 1 (PD-L1) and the tumor mutation burden (TMB) hold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63cd89f89f98703dba24727d20d703ab
https://pubmed.ncbi.nlm.nih.gov/31807880
https://pubmed.ncbi.nlm.nih.gov/31807880