Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Hideaki Kusaka"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 124, Iss 2, Pp 201-207 (2014)
The mouse embryonic stem cell test (mEST) is used to assess the embryotoxicity of drug candidates by evaluating the effects on the cardiac differentiation of stem cells. However, thalidomide embryotoxicity has not yet been reported using the mEST. To
Externí odkaz:
https://doaj.org/article/97118b9707994356b8d386e4aa7b3fbe
Publikováno v:
Journal of Pharmacological Sciences, Vol 124, Iss 2, Pp 201-207 (2014)
The mouse embryonic stem cell test (mEST) is used to assess the embryotoxicity of drug candidates by evaluating the effects on the cardiac differentiation of stem cells. However, thalidomide embryotoxicity has not yet been reported using the mEST. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd1d939a61088ab7b18ae02faa05120
https://doi.org/10.1254/jphs.13162fp
https://doi.org/10.1254/jphs.13162fp
Autor:
Hideaki Kusaka, Hiromichi Kosaka, Nobuyuki Yoda, Sasaki Katsutoshi, Masahiro Matsubara, Tetsuya Kitayama, Kazunori Hirayama
Publikováno v:
European Journal of Pharmacology. 635:49-55
Aldosterone-induced activation of mineralocorticoid receptor, a member of the nuclear receptor family, results in increased tissue damage such as vascular inflammation and cardiac and perivascular fibrosis. Benidipine, a long-lasting dihydropyridine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278cca442956b4a62c7347a521386000
https://doi.org/10.1016/j.ejphar.2010.03.018
https://doi.org/10.1016/j.ejphar.2010.03.018
Autor:
Tadakazu Akiyama, Kanji Nagai, Shi-chuan Zhang, Takahiro Hasebe, Shin'ichi Miyamoto, Yoshimi Tokuda, Michio Nakamura, Hironobu Minami, Hideaki Kusaka, Hiroyuki Maeda, Kazuhiro Araki, Takafumi Sangai, Atsushi Ochiai, Genichiro Ishii
Publikováno v:
International Journal of Cancer. 118:2602-2608
Multiple myeloma (MM) is a fatal disease that affects plasma cells. Patients with MM have 1 or more osteolytic lesions in their bone tissues, where insulin-like growth factors (IGFs; IGF-I and IGF-II) are mainly stored. The role of bone-derived IGFs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a984bf2663a45873e7154254e1dc23b4
https://doi.org/10.1002/ijc.21653
https://doi.org/10.1002/ijc.21653
Autor:
Toshihiko Ishii, Yoshimi Maekawa-Tokuda, Akira Tanaka, Kenya Shitara, Teruyoshi Imada, Shiro Akinaga, Naoki Shimada, Katsumi Takaba, Hideaki Kusaka, Kumiko Maruyama-Takahashi, Yuka Sasaki
Publikováno v:
Clinical Cancer Research. 11:3897-3904
Purpose: Fibroblast growth factor 8b (FGF8b) has been implicated in oncogenesis of sex hormone–related malignancies. A murine monoclonal anti-FGF8 antibody, KM1334, has been raised against a FGF8b-derived peptide and shown to neutralize FGF8b activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d03e67c22435b1964eff506d96093fd8
https://doi.org/10.1158/1078-0432.ccr-04-2358
https://doi.org/10.1158/1078-0432.ccr-04-2358
Autor:
Yoji Ino, Yoshihisa Ohta, Tetsuya Tsujita, Seiho Okamoto, Ryuichiro Nakai, Nobuyoshi Amishiro, Takeshi Takahashi, Kazuhiko Kato, Yoshinori Yamashita, Junichiro Yamamoto, Shiro Akinaga, Hideaki Kusaka, Mitsuharu Araki, Chikara Murakata
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(16)
The 2,4,5-substituted-1,3,4-thiadiazoline derivative 1a has been identified as a new class of mitotic kinesin Eg5 inhibitor. With the aim of enhancement of the mitotic phase accumulation activity, structure optimization of side chains at the 2-, 4-,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2aa67a01233fbd9989dafe59dc7bb8b
https://pubmed.ncbi.nlm.nih.gov/25001485
https://pubmed.ncbi.nlm.nih.gov/25001485
Publikováno v:
Journal of Cardiovascular Pharmacology. 33:440-450
In a previous study, we showed that caffeine (CAFF) increases basal renin secretion by blocking intrarenal adenosine receptors and, when sympathetic activity is increased, augments renin release in part by blockade of brain adenosine receptors, leadi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd561c1224c6a372d77541bb5ea1acc
https://doi.org/10.1097/00005344-199903000-00015
https://doi.org/10.1097/00005344-199903000-00015
Publikováno v:
Clinical and Experimental Hypertension. 20:329-344
Adenosine is an ubiquitously occurring endogenous nucleoside that via cell surface receptors exerts multiple antihypertensive actions, and mediates a number of biological responses that may reduce cardiovascular disease risk. Therefore modulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a099331284feeb4d74973b81f87f9dae
https://doi.org/10.3109/10641969809052125
https://doi.org/10.3109/10641969809052125
Publikováno v:
Japanese Journal of Pharmacology. 68:389-396
We determined the effects of KW-3902 (8-(noradamantan-3-yl)-1,3- dipropylxanthine), a novel adenosine A1-receptor antagonist, on the development of hypertension in Dahl salt-sensitive (Dahl-S) rats. KW-3902 (0.00017% w/w-0.017% w/w), fed with the die
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ec35b0dd160f761c0288cbcf1b8196
https://doi.org/10.1254/jjp.68.389
https://doi.org/10.1254/jjp.68.389
Publikováno v:
Japanese Journal of Pharmacology. 68:213-216
We investigated the effects of KW-3902 (8-(noradamantan-3-yl)-1, 3-dipropylxanthine), a potent adenosine A1-receptor antagonist, on the nephrotic edema induced by puromycin aminonucleoside (PAN; 100 mg/kg, i.v.) in rats. The treatment with PAN decrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d0e453a147af4cda441ab857e923ab
https://doi.org/10.1254/jjp.68.213
https://doi.org/10.1254/jjp.68.213