Zobrazeno 1 - 10
of 706
pro vyhledávání: '"Hideaki Hara"'
Autor:
Shinsuke Nakamura, Rie Yamamoto, Takaya Matsuda, Hiroto Yasuda, Anri Nishinaka, Kei Takahashi, Yuki Inoue, Sadao Kuromitsu, Masamitsu Shimazawa, Masahide Goto, Shuh Narumiya, Hideaki Hara
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Ocular abnormal angiogenesis and edema are featured in several ocular diseases. S1P signaling via S1P1 likely is part of the negative feedback mechanism necessary to maintain vascular health. In this study, we conducted pharmacological exper
Externí odkaz:
https://doaj.org/article/b3f0c584a6654d6986335acb20a55dc8
Autor:
Kanta Yamazaki, Kodai Ishida, Wataru Otsu, Aomi Muramatsu, Shinsuke Nakamura, Wakana Yamada, Hideshi Tsusaki, Hiroshi Shimoda, Hideaki Hara, Masamitsu Shimazawa
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background Blue light exposure is known to induce reactive oxygen species (ROS) production and increased endoplasmic reticulum stress, leading to apoptosis of photoreceptors. Maqui berry (Aristotelia chilensis) is a fruit enriched in anthocy
Externí odkaz:
https://doaj.org/article/d865dad8afd8404b82ffe56ad659dd73
Publikováno v:
FASEB BioAdvances, Vol 5, Iss 10, Pp 395-411 (2023)
Abstract Myocardial infarction (MI) is a lethal disease that causes irreversible cardiomyocyte death and subsequent cardiovascular remodeling. We have previously shown that the administration of recombinant progranulin (PGRN) protects against myocard
Externí odkaz:
https://doaj.org/article/e5899a43e4154047b0d500b993546eaf
Autor:
Kazuhisa Yamada, Akira Tazaki, Nanako Ushio-Watanabe, Yoshihiko Usui, Atsunobu Takeda, Masaaki Matsunaga, Ayana Suzumura, Hideyuki Shimizu, Hao Zheng, Nanang R. Ariefta, Masahiro Yamamoto, Hideaki Hara, Hiroshi Goto, Koh-Hei Sonoda, Koji M. Nishiguchi, Masashi Kato, Yoshifumi Nishikawa, Shinya Toyokuni, Hiroki Kaneko
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102890- (2023)
Toxoplasmosis is a major infectious disease, affecting approximately one-third of the world's population; its main clinical manifestation, ocular toxoplasmosis (OT), is a severe sight-threatening disease. Nevertheless, the diagnosis of OT is based on
Externí odkaz:
https://doaj.org/article/51daca73f1e740f5bad41ac0eb80d288
Autor:
Wataru Otsu, Tomohiro Yako, Emi Sugisawa, Shinsuke Nakamura, Hideshi Tsusaki, Naofumi Umigai, Masamitsu Shimazawa, Hideaki Hara
Publikováno v:
Journal of Pharmacological Sciences, Vol 150, Iss 4, Pp 279-288 (2022)
The corneal epithelium is located at the outermost layer of the ocular surface and continuously exposed to environmental factors, such as ultraviolet (UV) radiation from sunlight. UV irradiation causes excessive production of reactive oxygen species
Externí odkaz:
https://doaj.org/article/ebe40e94454f4839a05ac87daad2912d
Autor:
Hideaki Hara, Junseok Han, Yasutaka Imai, Noboru Sasao, Akihiro Yoshimi, Koji Yoshimura, Motohiko Yoshimura, Yuki Miyamoto
Publikováno v:
Physical Review Research, Vol 6, Iss 1, p 013005 (2024)
We observed periodic optical pulses from an Er:YSO crystal during irradiating with a continuous-wave excitation laser. We refer to this phenomenon as “periodic superradiance.” This periodicity can be understood qualitatively by a simple model, in
Externí odkaz:
https://doaj.org/article/4a0afaa952e845689afd801a904f3e3a
Autor:
Yuta Ohno, Tomohiro Yako, Keitaro Satoh, Haruna Nagase, Akiko Shitara, Hideaki Hara, Masanori Kashimata
Publikováno v:
Journal of Pharmacological Sciences, Vol 149, Iss 1, Pp 20-26 (2022)
Early detection of such retinal diseases as glaucoma and age-related macular degeneration (AMD) is important to prevent blindness. There have been reports of changes in some components in the tears of glaucoma and AMD patients, suggesting tears' pote
Externí odkaz:
https://doaj.org/article/5c4d8c0ecab14f8897f2a1e8fc6f982b
Autor:
Hirofumi Matsubara, Takahiko Imai, Shohei Tsuji, Natsumi Oka, Yusuke Egashira, Yukiko Enomoto, Noriyuki Nakayama, Shinsuke Nakamura, Masamitsu Shimazawa, Toru Iwama, Hideaki Hara
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 65-72 (2022)
This study aimed to evaluate the effects of nafamostat, a serin protease inhibitor, in the management of subarachnoid hemorrhage (SAH). SAH was induced by endovascular perforation in male mice. Nafamostat was administered intraperitoneally four times
Externí odkaz:
https://doaj.org/article/7cdb7c0464d34752bdf319921347a145
Autor:
Honoka Fujimori, Takuya Ohba, Masashi Mikami, Shinsuke Nakamura, Kenichi Ito, Hiroyuki Kojima, Tatsuji Takahashi, Arunasiri Iddamalgoda, Masamitsu Shimazawa, Hideaki Hara
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 162-171 (2022)
Alzheimer's disease (AD) is characterized by progressive cognitive decline, and the number of affected individuals has increased worldwide. However, there are no effective treatments for AD. Therefore, it is important to prevent the onset of dementia
Externí odkaz:
https://doaj.org/article/3d55ef5857af4bbaaa120fb1b9bc7cec
Publikováno v:
Journal of Pharmacological Sciences, Vol 147, Iss 4, Pp 367-375 (2021)
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by CAG repeat expansion in the huntingtin (HTT) gene. Here, we examined the effects of antioxidants on 3-nitropropionic acid (3-NP; a mitochondrial complex II inhibitor)-indu
Externí odkaz:
https://doaj.org/article/f23ab132a29f4a4b80ae396a6cbf0861