Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Hideaki Funami"'
Autor:
Ryutaro Kanada, Yoshiko Kagoshima, Takashi Suzuki, Akifumi Nakamura, Hideaki Funami, Jun Watanabe, Masayoshi Asano, Mizuki Takahashi, Osamu Ubukata, Kanae Suzuki, Tomoya Aikawa, Kazumi Sato, Megumi Goto, Genzui Setsu, Kentaro Ito, Kawori Kihara, Mutsumi Kuroha, Takashi Kohno, Hideaki Ogiwara, Takeshi Isoyama, Yuichi Tominaga, Saito Higuchi, Hiroyuki Naito
Publikováno v:
Journal of medicinal chemistry.
Histone acetylation is a post-translational modification of histones that is catalyzed by histone acetyltransferases (HATs) and plays an essential role in cellular processes. The HAT domain of EP300/CBP has recently emerged as a potential drug target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b85052fce6ba975a5f0b046a0c345b1
https://pubmed.ncbi.nlm.nih.gov/36572866
https://pubmed.ncbi.nlm.nih.gov/36572866
Autor:
Hideaki Funami, Makoto Shibata, Makoto Koyama, Tsuyoshi Muto, Bitoku Takahashi, Hiroshi Maruoka, Satomi Kanki
Publikováno v:
Chemicalpharmaceutical bulletin. 63(10)
Structural optimization of 2-aminonicotinamide derivatives as ghrelin receptor inverse agonists is reported. So as to avoid mechanism-based inactivation (MBI) of CYP3A4, 1,3-benzodioxol ring of the lead compound was modified. Improvement of the main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de43024c0d1280c7ef783927b60c3316
https://pubmed.ncbi.nlm.nih.gov/26423040
https://pubmed.ncbi.nlm.nih.gov/26423040
Autor:
Makoto Koyama, Tsuyoshi Muto, Hideaki Funami, Bitoku Takahashi, Satomi Kanki, Hiroshi Maruoka, Makoto Shibata, Asako Nagahira, Takehiko Iwaki, Yoshiyuki Igawa, Yoshiyuki Kamiide
Publikováno v:
Bioorganicmedicinal chemistry. 23(15)
A series of 2-alkylamino nicotinamide analogs was prepared as orally active ghrelin receptor (ghrelinR) inverse agonists. Starting from compound 1, oral bioavailability was improved by modifying metabolically unstable sites and reducing molecular wei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84c59ba7f8c77cf5db4cec9361324107
https://pubmed.ncbi.nlm.nih.gov/26100441
https://pubmed.ncbi.nlm.nih.gov/26100441
Autor:
Asako Nagahira, Tsuyoshi Matsuo, Makoto Koyama, Yoshiyuki Kamiide, Hirokazu Annoura, Takehiko Iwaki, Hideaki Funami, Tsuyoshi Muto, Bitoku Takahashi, Hiroshi Maruoka
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(13)
New inverse agonists of the ghrelin receptor (ghrelinR) were obtained through high-throughput screening and subsequent structural modification of 2-aminoalkyl nicotinamide derivatives. The key structural feature to improve in vitro activity was the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaff2acbe6d8f92b58c2a2515216fae2
https://pubmed.ncbi.nlm.nih.gov/25981690
https://pubmed.ncbi.nlm.nih.gov/25981690
Autor:
Jun Takaya, Masahide Shido, Yoshihiro Hara, Hiroyuki Kusama, Hideaki Funami, Nobuharu Iwasawa
Publikováno v:
Journal of the American Chemical Society. 127:2709-2716
Novel tungsten-containing carbonyl ylides 7, generated by the reaction of the o-alkynylphenyl carbonyl derivatives 1 with a catalytic amount of W(CO)(5)(thf), reacted with alkenes to give polycyclic compounds 5 through [3 + 2]-cycloaddition reaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12b87cc2a09234b2b2f15e14ded1b42
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100530426
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100530426
Publikováno v:
ChemInform. 41
A Pt(II)-catalyzed [3 + 2] cycloaddition reaction of silyl propadienyl ethers and alkenyl ethers has been developed as the first example of the utilization of allenes as a three-carbon unit in a transition-metal-catalyzed intermolecular cycloaddition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::988f6fc3a9b49a6d573dac8db515b01d
https://doi.org/10.1002/chin.201012070
https://doi.org/10.1002/chin.201012070
Publikováno v:
ChemInform. 39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b726abf1de36c51be4bee24e4bdf6129
https://doi.org/10.1002/chin.200845141
https://doi.org/10.1002/chin.200845141
Publikováno v:
Angewandte Chemie (International ed. in English). 47(26)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6478c0a40d8fa91aef59f9b0ed45c59c
https://pubmed.ncbi.nlm.nih.gov/18496797
https://pubmed.ncbi.nlm.nih.gov/18496797
Publikováno v:
ChemInform. 38
A concise method for the preparation of 1-acyl-4-alkoxy- or 1-acyl-4-alkylsulfanylnaphthalenes has been developed by the PtCl 2 -catalyzed reaction of O-ethynylbenzoates or benzothioates with vinyl ethers. Treatment of O-alkynylbenzoate derivatives w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300b955504bbe9937b015773be814178
https://doi.org/10.1002/chin.200747097
https://doi.org/10.1002/chin.200747097
Publikováno v:
ChemInform. 38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b44a2cdb9ea381f2e54c0f2036388c1
https://doi.org/10.1002/chin.200718056
https://doi.org/10.1002/chin.200718056