Zobrazeno 1 - 10
of 292
pro vyhledávání: '"Hideaki, Kakeya"'
Autor:
Atsuhiro Kishimoto, Maki Komiyama, Hiromichi Wada, Noriko Satoh-Asahara, Hajime Yamakage, Yoichi Ajiro, Hiroki Aoyama, Yasuhiro Katsuura, Atsushi Imaizumi, Tadashi Hashimoto, Yoichi Sunagawa, Tatsuya Morimoto, Masashi Kanai, Hideaki Kakeya, Koji Hasegawa
Publikováno v:
Journal of Health, Population and Nutrition, Vol 43, Iss 1, Pp 1-8 (2024)
Abstract Introduction Even after the peak of the COVID-19 pandemic, the number of mild cases remains high, requiring continuous control. Curcumin, owing to its anti-inflammatory properties, can suppress vital proliferation and cytokine secretion in a
Externí odkaz:
https://doaj.org/article/e6b5b9696d7748c48687ec730ab87386
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 445-451 (2024)
The adenylation (A) domain is essential for non-ribosomal peptide synthetases (NRPSs), which synthesize various peptide-based natural products, including virulence factors, such as siderophores and genotoxins. Hence, the inhibition of A-domains could
Externí odkaz:
https://doaj.org/article/fda6b33ee917401da302b4b9d9863f7f
Autor:
Yutaka Furutani, Yoshinori Hirano, Mariko Toguchi, Shoko Higuchi, Xian-Yang Qin, Kaori Yanaka, Yumi Sato-Shiozaki, Nobuaki Takahashi, Marina Sakai, Pornparn Kongpracha, Takehiro Suzuki, Naoshi Dohmae, Mutsuko Kukimoto-Niino, Mikako Shirouzu, Shushi Nagamori, Harukazu Suzuki, Kaoru Kobayashi, Takahiro Masaki, Hiroo Koyama, Kazuma Sekiba, Motoyuki Otsuka, Kazuhiko Koike, Michinori Kohara, Soichi Kojima, Hideaki Kakeya, Tomokazu Matsuura
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract IFN-alpha have been reported to suppress hepatitis B virus (HBV) cccDNA via APOBEC3 cytidine deaminase activity through interferon signaling. To develop a novel anti-HBV drug for a functional cure, we performed in silico screening of the bin
Externí odkaz:
https://doaj.org/article/a95194b3f0af40dea3e8ffa9ef2e29cd
Autor:
Toshiki Ochiai, Tensei Inukai, Manato Akiyama, Kairi Furui, Masahito Ohue, Nobuaki Matsumori, Shinsuke Inuki, Motonari Uesugi, Toshiaki Sunazuka, Kazuya Kikuchi, Hideaki Kakeya, Yasubumi Sakakibara
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract The structural diversity of chemical libraries, which are systematic collections of compounds that have potential to bind to biomolecules, can be represented by chemical latent space. A chemical latent space is a projection of a compound str
Externí odkaz:
https://doaj.org/article/e5457904f4f54e489f843f4e0261fb18
Autor:
Mayuki Sasaki, Shinichi Nishimura, Yoko Yashiroda, Akihisa Matsuyama, Hideaki Kakeya, Minoru Yoshida
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105659- (2022)
Summary: FK506-binding protein with a molecular weight of 12 kDa (FKBP12) is a receptor of the immunosuppressive drugs, FK506 and rapamycin. The physiological functions of FKBP12 remain ambiguous because of its nonessentiality and multifunctionality.
Externí odkaz:
https://doaj.org/article/ac8ed75078e34e58b9b68fb12e9be41b
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/69c780201a934d4bb76bedf4757bf9c5
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
We developed a prodrug type of curcumin, curcumin monoglucuronide (CMG), whose intravenous/intraperitoneal injection achieves a high serum concentration of free-form curcumin. Although curcumin has been reported to alter the gut microbiota and immune
Externí odkaz:
https://doaj.org/article/b1ab5539dccd4d6489c288f6f55bc212
Autor:
Yoichi Sunagawa, Masafumi Funamoto, Shogo Sono, Kana Shimizu, Satoshi Shimizu, Mai Genpei, Yusuke Miyazaki, Yasufumi Katanasaka, Eriko Morimoto, Morio Ueno, Maki Komiyama, Hideaki Kakeya, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
Publikováno v:
Journal of Pharmacological Sciences, Vol 136, Iss 4, Pp 212-217 (2018)
The natural compound, curcumin (CUR), possesses several pharmacological properties, including p300-specific histone acetyltransferase (HAT) inhibitory activity. In our previous study, we demonstrated that CUR could prevent the development of cardiac
Externí odkaz:
https://doaj.org/article/466bb888092b41d9b00f70db1ef7f77c
Publikováno v:
The Analyst. 148:1209-1213
We developed a system to separate and identify racemised and isomerised aspartic acid residues in amyloid β by labeling with an original chiral resolution labeling reagent, d-FDLDA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53aafc7a2cc88812f370a27daf0c481a
https://doi.org/10.1039/d2an01885c
https://doi.org/10.1039/d2an01885c
Autor:
Toshiki Ochiai, Tensei Inukai, Manato Akiyama, Kairi Furui, Masahito Ohue, Nobuaki Matsumori, Shinsuke Inuki, Motonari Uesugi, Toshiaki Sunazuka, Kazuya Kikuchi, Hideaki Kakeya, Yasubumi Sakakibara
The structural diversity of chemical libraries, which are systematic collections of compounds that have potential to bind to biomolecules, can be represented by chemical latent space. A chemical latent space is a projection of a compound structure in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8c168523f29e345bc2c613fa98e8dfa
https://doi.org/10.26434/chemrxiv-2023-pjl0w-v2
https://doi.org/10.26434/chemrxiv-2023-pjl0w-v2
