Preventive or promotive effects of PRNP polymorphic heterozygosity on the onset of prion disease

Autor: Hideaki Kai, Kenta Teruya, Atsuko Takeuchi, Yoshikazu Nakamura, Hidehiro Mizusawa, Masahito Yamada, Tetsuyuki Kitamoto

Publikováno v: Heliyon, Vol 9, Iss 3, Pp e13974- (2023)

The polymorphic heterozygosity of PRNP at codon 129 or 219 prevents the onset of sporadic Creutzfeldt-Jakob disease (sCJD). We investigated the association between polymorphic genotypes at codon 129 or 219 and comprehensive prion disease onset using

Externí odkaz: https://doaj.org/article/cfe210c0f1af49a286d17a58750424fe

Neuroimaging-pathological correlations of [18F]THK5351 PET in progressive supranuclear palsy

Autor: Aiko Ishiki, Ryuichi Harada, Hideaki Kai, Naomi Sato, Tomoko Totsune, Naoki Tomita, Shoichi Watanuki, Kotaro Hiraoka, Yoichi Ishikawa, Yoshihito Funaki, Ren Iwata, Shozo Furumoto, Manabu Tashiro, Hironobu Sasano, Tetsuyuki Kitamoto, Yukitsuka Kudo, Kazuhiko Yanai, Katsutoshi Furukawa, Nobuyuki Okamura, Hiroyuki Arai

Publikováno v: Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-10 (2018)

Abstract Recent positron emission tomography (PET) studies have demonstrated the accumulation of tau PET tracer in the affected region of progressive supranuclear palsy (PSP) cases. To confirm the binding target of radiotracer in PSP, we performed an

Externí odkaz: https://doaj.org/article/27689a71ca88485fb74afdca3053d8aa

Correlations of 18F-THK5351 PET with Postmortem Burden of Tau and Astrogliosis in Alzheimer Disease

Autor: Naoki Tomita, Manabu Tashiro, Tetsuro Tago, Tadaho Nakamura, Kazuhiko Yanai, Nobuyuki Okamura, Hironobu Sasano, Ryuichi Harada, Kotaro Hiraoka, Tetsuyuki Kitamoto, Yoichi Ishikawa, Shoichi Watanuki, Naomi Sato, Yoshihito Funaki, Yukitsuka Kudo, Ren Iwata, Hiroyuki Arai, Aiko Ishiki, Hideaki Kai, Shozo Furumoto, Katsutoshi Furukawa, Takeo Yoshikawa

Publikováno v: Journal of Nuclear Medicine. 59:671-674

Clinical PET studies using 18F-THK5351 have demonstrated significant tracer retention in sites susceptible to tau burden in Alzheimer disease (AD). However, the in vivo PET signal to reflect tau aggregates remains controversial. Methods: We examined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d13d207b8167b0d01ee76332106f6a0
https://doi.org/10.2967/jnumed.117.197426

Prion-specific and surrogate CSF biomarkers in Creutzfeldt-Jakob disease: diagnostic accuracy in relation to molecular subtypes and analysis of neuropathological correlates of p-tau and A$\upbeta$42 levels

Autor: Sabina Capellari, Simone Baiardi, Piero Parchi, Giulia Amore, Alison Green, Maurizio Pocchiari, Samir Abu-Rumeileh, Lynne McGuire, Alessia Franceschini, Marcello Rossi, Francesca Lattanzio, Ilaria Poggiolini, Anna Ladogana, Hideaki Kai

Publikováno v: Lattanzio, F, Abu-Rumeileh, S, Franceschini, A, Kai, H, Amore, G, Poggiolini, I, Rossi, M, Baiardi, S, McGuire, L, Ladogana, A, Pocchiari, M, Green, A, Capellari, S & Parchi, P 2017, ' Prion-specific and surrogate CSF biomarkers in Creutzfeldt-Jakob disease : diagnostic accuracy in relation to molecular subtypes and analysis of neuropathological correlates of p-tau and A beta 42 levels ', Acta Neuropathologica, vol. 133, no. 4, pp. 559-578 . https://doi.org/10.1007/s00401-017-1683-0
Acta Neuropathologica

The differential diagnosis of Creutzfeldt-Jakob disease (CJD) from other, sometimes treatable, neurological disorders is challenging, owing to the wide phenotypic heterogeneity of the disease. Real-time quaking-induced prion conversion (RT-QuIC) is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10c42b516b038c568302f853d5e2635
http://hdl.handle.net/11585/585302

Correlations of

Autor: Ryuichi, Harada, Aiko, Ishiki, Hideaki, Kai, Naomi, Sato, Katsutoshi, Furukawa, Shozo, Furumoto, Tetsuro, Tago, Naoki, Tomita, Shoichi, Watanuki, Kotaro, Hiraoka, Yoichi, Ishikawa, Yoshihito, Funaki, Tadaho, Nakamura, Takeo, Yoshikawa, Ren, Iwata, Manabu, Tashiro, Hironobu, Sasano, Tetsuyuki, Kitamoto, Kazuhiko, Yanai, Hiroyuki, Arai, Yukitsuka, Kudo, Nobuyuki, Okamura

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 59(4)

Clinical PET studies using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::14d998431431a1b857453197589de5ab
https://pubmed.ncbi.nlm.nih.gov/28864633