Zobrazeno 1 - 10
of 700
pro vyhledávání: '"Hidde L Ploegh"'
Autor:
Timothy A Bates, Mila Trank-Greene, Xammy Nguyenla, Aidan Anastas, Sintayehu K Gurmessa, Ilaria R Merutka, Shandee D Dixon, Anthony Shumate, Abigail R Groncki, Matthew AH Parson, Jessica R Ingram, Eric Barklis, John E Burke, Ujwal Shinde, Hidde L Ploegh, Fikadu G Tafesse
Publikováno v:
eLife, Vol 12 (2024)
Mycobacterium tuberculosis (Mtb) is known to survive within macrophages by compromising the integrity of the phagosomal compartment in which it resides. This activity primarily relies on the ESX-1 secretion system, predominantly involving the protein
Externí odkaz:
https://doaj.org/article/02546070fb4649659e3251bb6aab7254
Autor:
Jun Xu, Ah-Ram Kim, Ross W Cheloha, Fabian A Fischer, Joshua Shing Shun Li, Yuan Feng, Emily Stoneburner, Richard Binari, Stephanie E Mohr, Jonathan Zirin, Hidde L Ploegh, Norbert Perrimon
Publikováno v:
eLife, Vol 11 (2022)
Expansion of the available repertoire of reagents for visualization and manipulation of proteins will help understand their function. Short epitope tags linked to proteins of interest and recognized by existing binders such as nanobodies facilitate p
Externí odkaz:
https://doaj.org/article/148fb076ed4841d3884faca2697e01b7
Autor:
Rhogerry Deshycka, Valentino Sudaryo, Nai-Jia Huang, Yushu Xie, Liyan Y Smeding, Moon Kyung Choi, Hidde L Ploegh, Harvey F Lodish, Novalia Pishesha
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0259353 (2021)
Low plasma levels of Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) are associated with decreased low-density lipoprotein (LDL) cholesterol and a reduced risk of cardiovascular disease. PCSK9 binds to the epidermal growth factor-like repeat A (EGFA
Externí odkaz:
https://doaj.org/article/578e74400dc64fdb8e36d78c1909d017
Autor:
Timothy F Miles, Katja Spiess, Kevin M Jude, Naotaka Tsutsumi, John S Burg, Jessica R Ingram, Deepa Waghray, Gertrud M Hjorto, Olav Larsen, Hidde L Ploegh, Mette M Rosenkilde, K Christopher Garcia
Publikováno v:
eLife, Vol 7 (2018)
Human cytomegalovirus has hijacked and evolved a human G-protein-coupled receptor into US28, which functions as a promiscuous chemokine 'sink’ to facilitate evasion of host immune responses. To probe the molecular basis of US28’s unique ligand cr
Externí odkaz:
https://doaj.org/article/ff0943aefac04d7b91e5b86d46807864
Publikováno v:
eLife, Vol 5 (2016)
The most common cause of early onset primary dystonia, a neuromuscular disease, is a glutamate deletion (ΔE) at position 302/303 of TorsinA, a AAA+ ATPase that resides in the endoplasmic reticulum. While the function of TorsinA remains elusive, the
Externí odkaz:
https://doaj.org/article/590bf7627f754e85bd29c6686a901af3
Autor:
Matthias C Truttmann, Victor E Cruz, Xuanzong Guo, Christoph Engert, Thomas U Schwartz, Hidde L Ploegh
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006023 (2016)
Protein AMPylation by Fic domain-containing proteins (Fic proteins) is an ancient and conserved post-translational modification of mostly unexplored significance. Here we characterize the Caenorhabditis elegans Fic protein FIC-1 in vitro and in vivo.
Externí odkaz:
https://doaj.org/article/f006fa9722db4bc18427a961a2042a79
Autor:
Fikadu G Tafesse, Ali Rashidfarrokhi, Florian I Schmidt, Elizaveta Freinkman, Stephanie Dougan, Michael Dougan, Alexandre Esteban, Takeshi Maruyama, Karin Strijbis, Hidde L Ploegh
Publikováno v:
PLoS Pathogens, Vol 11, Iss 10, p e1005188 (2015)
The ability of phagocytes to clear pathogens is an essential attribute of the innate immune response. The role of signaling lipid molecules such as phosphoinositides is well established, but the role of membrane sphingolipids in phagocytosis is large
Externí odkaz:
https://doaj.org/article/4263f524276e4c78800624d05e8bce7c
Autor:
Brian A Sosa, F Esra Demircioglu, James Z Chen, Jessica Ingram, Hidde L Ploegh, Thomas U Schwartz
Publikováno v:
eLife, Vol 3 (2014)
Lamina-associated polypeptide 1 (LAP1) resides at the nuclear envelope and interacts with Torsins, poorly understood endoplasmic reticulum (ER)-localized AAA+ ATPases, through a conserved, perinuclear domain. We determined the crystal structure of th
Externí odkaz:
https://doaj.org/article/be3518d292804c18b18e8baad5f90712
Autor:
Karin Strijbis, Omer H Yilmaz, Stephanie K Dougan, Alexandre Esteban, Andrea Gröne, Carol A Kumamoto, Hidde L Ploegh
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112472 (2014)
The commensal yeast Candida albicans is part of the human intestinal microflora and is considered a "pathobiont", a resident microbe with pathogenic potential yet harmless under normal conditions. The aim of this study was to investigate the effect o
Externí odkaz:
https://doaj.org/article/d78ed842a1f34b2992af7746b1229d8d
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90204 (2014)
Secretory and membrane (glyco)proteins are subject to quality control in the endoplasmic reticulum (ER) to ensure that only functional proteins reach their destination. Proteins deemed terminally misfolded and hence functionally defective may be disl
Externí odkaz:
https://doaj.org/article/9383575431924db89ed86e149e01aa8c