Small Molecule MIF Modulation Enhances Ferroptosis by Impairing DNA Repair Mechanisms

Autor: Deng Chen, Chunlong Zhao, Jianqiu Zhang, Catharina W. J. Knol, Angelina Osipyan, Nad'a Majerníková, Tingting Chen, Zhangping Xiao, Jeaunice Adriana, Andrew J. Griffith, Abel Soto Gamez, Petra E. van derWouden, Robert P. Coppes, Amalia M. Dolga, Hidde J. Haisma, Frank J. Dekker

Publikováno v: Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)

Abstract Ferroptosis is a form of regulated cell death that can be modulated by small molecules and has the potential for the development of therapeutics for oncology. Although excessive lipid peroxidation is the defining hallmark of ferroptosis, DNA

Externí odkaz: https://doaj.org/article/5f1b5535d1c64d3381cee0b2777a4e5b

CRISPR-mediated ablation of overexpressed EGFR in combination with sunitinib significantly suppresses renal cell carcinoma proliferation.

Autor: Bin Liu, Olivia Adaly Diaz Arguello, Deng Chen, Siwei Chen, Ali Saber, Hidde J Haisma

Publikováno v: PLoS ONE, Vol 15, Iss 5, p e0232985 (2020)

Receptor tyrosine kinases, such as VEGFR, PDGFR and EGFR, play important roles in renal cancer. In this study, we investigated EGFR knockout as a therapeutic approach in renal cell carcinoma (RCC). We showed that a renal cell carcinoma cell line (RC2

Externí odkaz: https://doaj.org/article/aa710188f7ce45218d0c2064806524af

Autologous stem cell therapy in knee osteoarthritis: a systematic review of randomised controlled trials

Autor: Tom Gh Wiggers, Marinus Winters, Noortje Ac Van den Boom, Maarten H. Moen, Hidde J. Haisma

Publikováno v: Wiggers, T G, Winters, M, Van den Boom, N A, Haisma, H J & Moen, M H 2021, ' Autologous stem cell therapy in knee osteoarthritis : a systematic review of randomised controlled trials ', British Journal of Sports Medicine, vol. 55, no. 20, 103671, pp. 1161-1169 . https://doi.org/10.1136/bjsports-2020-103671

ObjectiveStem cell therapy is increasingly used for knee osteoarthritis (KOA). We aimed to review the evidence of autologous mesenchymal stem cell therapy on pain, function and severity on imaging in KOA.DesignSystematic review of randomised controll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085f2d4e42febf7a4bca6a06e71c78e5
https://doi.org/10.1136/bjsports-2020-103671

HDAC/MIF dual inhibitor inhibits NSCLC cell survival and proliferation by blocking the AKT pathway

Autor: Siwei Chen, Frank J. Dekker, Fangyuan Cao, Deng Chen, Hidde J. Haisma, Zhangping Xiao, Chunlong Zhao

Publikováno v: Bioorganic Chemistry, 117:105396

Non-small-cell lung carcinoma (NSCLC) is one of the most common forms of lung cancer, and a leading cause of cancer death among human beings. There is an urgent demand for novel therapeutics for the treatment of NSCLC to enhance the efficacy of the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04286ac6ae35e56205bc62defec17e0d
https://research.rug.nl/en/publications/e9dbdd25-02d8-40e0-baa8-a300ef9e0a6f

A next-generation sequencing method for gene doping detection that distinguishes low levels of plasmid DNA against a background of genomic DNA

Autor: Lennart Johansson, Petra E van der Wouden, Eddy N. de Boer, Cleo C. van Diemen, Hidde J. Haisma

Publikováno v: Gene Therapy
Gene Therapy, 26(7-8), 338-346. Nature Publishing Group

Gene doping confers health risks for athletes and is a threat to fair competition in sports. Therefore the anti-doping community has given attention on its detection. Previously published polymerase chain reaction-based methodologies for gene doping

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f0c72eb9bfc332c8a543db35b8ea0c
https://doi.org/10.1038/s41434-019-0091-6