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Akademický článek

Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments.

Autor: Paul Fransen, Cor E Van Hove, Arthur J A Leloup, Wim Martinet, Guido R Y De Meyer, Katrien Lemmens, Hidde Bult, Dorien M Schrijvers

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0121634 (2015)

L-type Ca2+ channel (VGCC) mediated Ca2+ influx in vascular smooth muscle cells (VSMC) contributes to the functional properties of large arteries in arterial stiffening and central blood pressure regulation. How this influx relates to steady-state co

Externí odkaz: https://doaj.org/article/ab883a644be34d4397516909a7064faf

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Akademický článek

Transcript and protein analysis reveals better survival skills of monocyte-derived dendritic cells compared to monocytes during oxidative stress.

Autor: Ilse Van Brussel, Dorien M Schrijvers, Wim Martinet, Isabel Pintelon, Maartje Deschacht, Kathy Schnorbusch, Louis Maes, Johan M Bosmans, Christiaan J Vrints, Dirk Adriaensen, Paul Cos, Hidde Bult

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e43357 (2012)

BACKGROUND: Dendritic cells (DCs), professional antigen-presenting cells with the unique ability to initiate primary T-cell responses, are present in atherosclerotic lesions where they are exposed to oxidative stress that generates cytotoxic reactive

Externí odkaz: https://doaj.org/article/5384dbadb825476c9dec90b66bb2cb48

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Akademický článek

Dendritic Cells in Human Atherosclerosis: From Circulation to Atherosclerotic Plaques

Autor: Emily A. Van Vré, Ilse Van Brussel, Johan M. Bosmans, Christiaan J. Vrints, Hidde Bult

Publikováno v: Mediators of Inflammation, Vol 2011 (2011)

Background. Atherosclerosis is a chronic inflammatory disease with atherosclerotic plaques containing inflammatory infiltrates predominantly consisting of monocytes/macrophages and activated T cells. More recent is the implication of dendritic cells

Externí odkaz: https://doaj.org/article/59c7fca74f634d53b52b8cfa58c206bd

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Elastin fragmentation in atherosclerotic mice leads to intraplaque neovascularization, plaque rupture, myocardial infarction, stroke, and sudden death

Publikováno v: European Heart Journal
European Heart Journal, 36(17), 1049-1058A. Oxford University Press
European heart journal

Our study underscores the importance of elastin fragmentation in the vessel wall as an accelerator of atherosclerosis with enhanced inflammation and increased neovascularization, thereby promoting the development of unstable plaques that eventually m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e429d3ad660db36bac46a11b316e2243
http://europepmc.org/articles/PMC4416138

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Selective loss of basal but not receptor-stimulated relaxation by endothelial nitric oxide synthase after isolation of the mouse aorta

Autor: Wim Martinet, Dorien M. Schrijvers, Paul Fransen, Hidde Bult, Guido R.Y. De Meyer, Cor E. Van Hove, Johanna van Langen

Publikováno v: European journal of pharmacology

Bioavailability of nitric oxide (NO) is mostly studied in isolated blood vessels. We investigated changes in basal and receptor-stimulated endothelial NO synthase (eNOS) activity after isolation of wild-type and Marfan mouse aorta. Starting 1h after

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8384de84067aae2e6f781582c0edec0
https://doi.org/10.1016/j.ejphar.2012.09.016

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Resolute® and xience V® polymer-based drug-eluting stents compared in an atherosclerotic rabbit double injury model

Autor: Erik Fransen, Johan Bosmans, Hidde Bult, Jean-Pierre Timmermans, Steven Haine, Christiaan J. Vrints, Vicky Y. Hoymans, Christophe J. Van Dyck

Publikováno v: Catheterization and Cardiovascular Interventions. 81:E259-E268

Aim To evaluate differences in strut coverage, inflammation and endothelialization between two second-generation polymer-based drug-eluting stents (DES) in an atherosclerotic rabbit double-injury iliac artery model at 28 days follow-up. Methods and r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::820234cefd9bf2f9cf0598cc17cda025
https://doi.org/10.1002/ccd.24595

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Immunohistochemical characterisation of dendritic cells in human atherosclerotic lesions: possible pitfalls

Autor: Ilse Van Brussel, Hidde Bult, Paul E. Van Schil, Guido R.Y. De Meyer, Mieke Maris, Christiaan J. Vrints, Emily A. Van Vré, Johan Bosmans

Publikováno v: Pathology

Summary Background Previously we demonstrated decreased blood myeloid (m) and plasmacytoid (p) dendritic cell (DC) counts in atherosclerotic patients. Therefore, we examined whether DCs, in particular DC precursors, accumulate in human plaques. Metho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748f7ddac96b7265298b0c31b936e588
https://doi.org/10.1097/pat.0b013e328344e266

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Inhibition of inositol monophosphatase by lithium chloride induces selective macrophage apoptosis in atherosclerotic plaques

Autor: Hidde Bult, Dorien M. Schrijvers, Inge De Meyer, Vicky Y. Hoymans, Luc Van Vaeck, Wim Martinet, Cor E. Van Hove, Guido R.Y. De Meyer, Paul Fransen

Publikováno v: British Journal of Pharmacology. 162:1410-1423

BACKGROUND AND PURPOSE Lithium chloride (LiCl) inhibits inositol monophosphatase (IMPase) at therapeutic concentrations. Given that LiCl induces death in cultured macrophages and that macrophages play an active role in atherosclerotic plaque destabil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04481abcd6cc7a19526156631c97818e
https://doi.org/10.1111/j.1476-5381.2010.01152.x

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Changes in blood dendritic cell counts in relation to type of coronary artery disease and brachial endothelial cell function

Autor: Ilse Van Brussel, Emily A. Van Vré, Ken Op de Beeck, Christiaan J. Vrints, Hidde Bult, Vicky Y. Hoymans, Johan Bosmans

Publikováno v: Coronary artery disease

Background Recently we reported a decline of circulating myeloid (m) and plasmacytoid (p) dendritic cells (DCs) in patients with coronary artery disease (CAD). This study also determined the total blood DC numbers and focused on effects of extent (on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6824f201bf2985171ba5ffc5a224e33c
https://doi.org/10.1097/mca.0b013e3283368c0e

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