Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Hidde, Elferink"'
Autor:
Jona Merx, Jordi C. J. Hintzen, Giordano Proietti, Hidde Elferink, Yali Wang, Miriam R. B. Porzberg, Daan Sondag, Nurgül Bilgin, Jin Park, Jasmin Mecinović, Thomas J. Boltje
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Posttranslational modifications (PTMs) on histone tails regulate eukaryotic gene expression by impacting the chromatin structure and by modulating interactions with other cellular proteins. One such PTM has been identified as serine and thre
Externí odkaz:
https://doaj.org/article/d417fc4ccbb649dca6141ab06c89fcda
Autor:
Thomas Hansen, Hidde Elferink, Jacob M. A. van Hengst, Kas J. Houthuijs, Wouter A. Remmerswaal, Alexandra Kromm, Giel Berden, Stefan van der Vorm, Anouk M. Rijs, Hermen S. Overkleeft, Dmitri V. Filippov, Floris P. J. T. Rutjes, Gijsbert A. van der Marel, Jonathan Martens, Jos Oomens, Jeroen D. C. Codée, Thomas J. Boltje
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Dioxolenium ion intermediates formed from remote positions are hypothesized to direct stereoselective glycosylations. Herein we combine infrared ion spectroscopy, DFT calculations and synthetic work to characterize and study these dioxolenium ions an
Externí odkaz:
https://doaj.org/article/6ec49b5d3eff4a6ea8a8b5a70ecb1904
Autor:
Floor ter Braak, Hidde Elferink, Kas J. Houthuijs, Jos Oomens, Jonathan Martens, Thomas J. Boltje
Publikováno v:
Accounts of Chemical Research, 55, 1669-1679
Accounts of Chemical Research, 55, 12, pp. 1669-1679
Accounts of Chemical Research, 55, 12, pp. 1669-1679
A detailed understanding of the reaction mechanism(s) leading to stereoselective product formation is crucial to understanding and predicting product formation and driving the development of new synthetic methodology. One way to improve our understan
Autor:
Jona Merx, Kas J. Houthuijs, Hidde Elferink, Eva Witlox, Jasmin Mecinović, Jos Oomens, Jonathan Martens, Thomas J. Boltje, Floris P. J. T. Rutjes
Publikováno v:
Chemistry : a European Journal, 28, 1-7
Chemistry : a European Journal, 28, 9, pp. 1-7
Merx, J, Houthuijs, K, Elferink, H, Witlox, E, Mecinović, J, Oomens, J, Martens, J, Boltje, T & Rutjes, F P J T 2022, ' Characterization of Cyclic N-Acyliminium Ions by Infrared Ion Spectroscopy ', Chemistry: A European Journal, vol. 28, no. 9, e202104078 . https://doi.org/10.1002/chem.202104078
Chemistry : a European Journal, 28, 9, pp. 1-7
Merx, J, Houthuijs, K, Elferink, H, Witlox, E, Mecinović, J, Oomens, J, Martens, J, Boltje, T & Rutjes, F P J T 2022, ' Characterization of Cyclic N-Acyliminium Ions by Infrared Ion Spectroscopy ', Chemistry: A European Journal, vol. 28, no. 9, e202104078 . https://doi.org/10.1002/chem.202104078
N- Acyliminium ions are highly reactive intermediates that are important for creating CC-bonds adjacent to nitrogen atoms. Here we report the characterization of cyclic N -acyliminium ions in the gas phase, generated by collision induced dissociation
Autor:
Hidde Elferink, Wouter A. Remmerswaal, Kas J. Houthuijs, Oscar Jansen, Thomas Hansen, Anouk M. Rijs, Giel Berden, Jonathan Martens, Jos Oomens, Jeroen D. C. Codée, Thomas J. Boltje
Publikováno v:
Chemistry-A European Journal, 28(63):e202201724, 1-8. Wiley-VCH Verlag
Chemistry: a European Journal, 28(63):e202201724
Chemistry: a European Journal, 28(63):e202201724. WILEY-V C H VERLAG GMBH
Chemistry : a European Journal, 28, 63, pp. 1-7
Elferink, H, Remmerswaal, W A, Houthuijs, K J, Jansen, O, Hansen, T, Rijs, A M, Berden, G, Martens, J, Oomens, J, Codée, J D C & Boltje, T J 2022, ' Competing C-4 and C-5-Acyl Stabilization of Uronic Acid Glycosyl Cations ', Chemistry-A European Journal, vol. 28, no. 63, e202201724, pp. 1-8 . https://doi.org/10.1002/chem.202201724
Chemistry : a European Journal, 28, 1-7
Chemistry: a European Journal, 28(63):e202201724
Chemistry: a European Journal, 28(63):e202201724. WILEY-V C H VERLAG GMBH
Chemistry : a European Journal, 28, 63, pp. 1-7
Elferink, H, Remmerswaal, W A, Houthuijs, K J, Jansen, O, Hansen, T, Rijs, A M, Berden, G, Martens, J, Oomens, J, Codée, J D C & Boltje, T J 2022, ' Competing C-4 and C-5-Acyl Stabilization of Uronic Acid Glycosyl Cations ', Chemistry-A European Journal, vol. 28, no. 63, e202201724, pp. 1-8 . https://doi.org/10.1002/chem.202201724
Chemistry : a European Journal, 28, 1-7
Uronic acids are carbohydrates carrying a terminal carboxylic acid and have a unique reactivity in stereoselective glycosylation reactions. Herein, the competing intramolecular stabilization of uronic acid cations by the C-5 carboxylic acid or the C-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13abe4d5caebc803f690299bb6b1cd1b
https://research.vu.nl/en/publications/7bbdd644-22fa-40f7-bb9c-8ace539559b9
https://research.vu.nl/en/publications/7bbdd644-22fa-40f7-bb9c-8ace539559b9
Autor:
Wouter A, Remmerswaal, Kas J, Houthuijs, Roel, van de Ven, Hidde, Elferink, Thomas, Hansen, Giel, Berden, Herman S, Overkleeft, Gijsbert A, van der Marel, Floris P J T, Rutjes, Dmitri V, Filippov, Thomas J, Boltje, Jonathan, Martens, Jos, Oomens, Jeroen D C, Codée
Publikováno v:
The Journal of organic chemistry. 87(14)
The stereoselective introduction of glycosidic bonds is of paramount importance to oligosaccharide synthesis. Among the various chemical strategies to steer stereoselectivity, participation by either neighboring or distal acyl groups is used particul
Publikováno v:
Angewandte Chemie, 61, 1-5
Angewandte Chemie, 61, 6, pp. 1-5
Angewandte Chemie, 61, 6, pp. 1-5
The stereoselective introduction of the glycosidic bond remains one of the main challenges in carbohydrate synthesis. Characterizing the reactive intermediates of this reaction is key to develop stereoselective glycosylation reactions. Herein we repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2321abf0163bf33bdbcdee3196eeaf9b
http://hdl.handle.net/2066/245662
http://hdl.handle.net/2066/245662
Autor:
Wouter A. Remmerswaal, Kas J. Houthuijs, Roel van de Ven, Hidde Elferink, Thomas Hansen, Giel Berden, Herman S. Overkleeft, Gijsbert A. van der Marel, Floris P. J. T. Rutjes, Dmitri V. Filippov, Thomas J. Boltje, Jonathan Martens, Jos Oomens, Jeroen D. C. Codée
Publikováno v:
Journal of Organic Chemistry (JOC), 87(14), 9139-9147. AMER CHEMICAL SOC
Journal of Organic Chemistry, 87, 9139-9147
Journal of Organic Chemistry, 87, 14, pp. 9139-9147
Remmerswaal, W A, Houthuijs, K J, Van De Ven, R, Elferink, H, Hansen, T, Berden, G, Overkleeft, H S, Van Der Marel, G A, Rutjes, F P J T, Filippov, D V, Boltje, T J, Martens, J, Oomens, J & Codée, J D C 2022, ' Stabilization of Glucosyl Dioxolenium Ions by "dual Participation" of the 2,2-Dimethyl-2-(ortho-nitrophenyl)acetyl (DMNPA) Protection Group for 1,2-cis-Glucosylation ', Journal of Organic Chemistry, vol. 87, no. 14, pp. 9139-9147 . https://doi.org/10.1021/acs.joc.2c00808
Journal of Organic Chemistry, 87(14), 9139-9147. American Chemical Society
Journal of Organic Chemistry, 87, 9139-9147
Journal of Organic Chemistry, 87, 14, pp. 9139-9147
Remmerswaal, W A, Houthuijs, K J, Van De Ven, R, Elferink, H, Hansen, T, Berden, G, Overkleeft, H S, Van Der Marel, G A, Rutjes, F P J T, Filippov, D V, Boltje, T J, Martens, J, Oomens, J & Codée, J D C 2022, ' Stabilization of Glucosyl Dioxolenium Ions by "dual Participation" of the 2,2-Dimethyl-2-(ortho-nitrophenyl)acetyl (DMNPA) Protection Group for 1,2-cis-Glucosylation ', Journal of Organic Chemistry, vol. 87, no. 14, pp. 9139-9147 . https://doi.org/10.1021/acs.joc.2c00808
Journal of Organic Chemistry, 87(14), 9139-9147. American Chemical Society
The stereoselective introduction of glycosidic bonds is of paramount importance to oligosaccharide synthesis. Among the various chemical strategies to steer stereoselectivity, participation by either neighboring or distal acyl groups is used particul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a58321247d741426ba6183eca07e93
https://doi.org/10.1021/acs.joc.2c00808
https://doi.org/10.1021/acs.joc.2c00808
Publikováno v:
Cellular and Molecular Life Sciences
The human body is able to process and transport a complex variety of carbohydrates, unlocking their nutritional value as energy source or as important building block. The endogenous glycosyl hydrolases (glycosidases) and glycosyl transporter proteins
Autor:
Anouk M. Rijs, Oscar Jansen, Jos Oomens, Jeroen P. J. Bruekers, Thomas J. Boltje, Rens A. Mensink, Jonathan Martens, Hidde Elferink, Wilke W. A. Castelijns
Publikováno v:
Angewandte Chemie. International Edition, 58, 26, pp. 8746-8751
Angewandte Chemie. International Edition, 58, 8746-8751
Angewandte Chemie International Edition
Angewandte Chemie. International Edition, 58, 8746-8751
Angewandte Chemie International Edition
Uronic acids are important constituents of polysaccharides found on the cell membranes of different organisms. To prepare uronic-acid-containing oligosaccharides, uronic acid 6,3-lactones can be employed as they display a fixed conformation and a uni