Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Hidaka Ikemoto"'
Autor:
Takahiro Kawajiri, Akihito Kijima, Atsuhiro Iimuro, Eisaku Ohashi, Katsuya Yamakawa, Kazushi Agura, Kengo Masuda, Kensuke Kouki, Koji Kasamatsu, Shuichi Yanagisawa, Sho Nakashima, Setsuya Shibahara, Takashi Toyota, Takafumi Higuchi, Takahiro Suto, Tadashi Oohara, Toshikatsu Maki, Naoto Sahara, Nobuaki Fukui, Hisayuki Wakamori, Hidaka Ikemoto, Hiroaki Murakami, Hiroyasu Ando, Masahiro Hosoya, Mizuki Sato, Yusuke Suzuki, Yuta Nakagawa, Yuto Unoh, Yoichi Hirano, Yoshitomo Nagasawa, Satoshi Goda, Takafumi Ohara, Takayuki Tsuritani
Publikováno v:
ACS Central Science, Vol 9, Iss 4, Pp 836-843 (2023)
Externí odkaz:
https://doaj.org/article/9f38b46b1b194cdaac85377b26776798
Autor:
Takahiro Kawajiri, Akihito Kijima, Atsuhiro Iimuro, Eisaku Ohashi, Katsuya Yamakawa, Kazushi Agura, Kengo Masuda, Kensuke Kouki, Koji Kasamatsu, Shuichi Yanagisawa, Sho Nakashima, Setsuya Shibahara, Takashi Toyota, Takafumi Higuchi, Takahiro Suto, Tadashi Oohara, Toshikatsu Maki, Naoto Sahara, Nobuaki Fukui, Hisayuki Wakamori, Hidaka Ikemoto, Hiroaki Murakami, Hiroyasu Ando, Masahiro Hosoya, Mizuki Sato, Yusuke Suzuki, Yuta Nakagawa, Yuto Unoh, Yoichi Hirano, Yoshitomo Nagasawa, Satoshi Goda, Takafumi Ohara, Takayuki Tsuritani
We describe the development of the practical manufacturing of Ensitrelvir, which was discovered as a SARS-CoV-2 antiviral candidate. Scalable synthetic methods of indazole, 1,2,4-triazole and 1,3,5-triazinone structures were established, and converge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6fe8efc31eb0dbe319232ced6f96b7a
https://doi.org/10.26434/chemrxiv-2022-wx3nl
https://doi.org/10.26434/chemrxiv-2022-wx3nl
Autor:
Yuusuke Tamura, Ippei Morita, Yu Hinata, Eiichi Kojima, Hiroki Ozasa, Hidaka Ikemoto, Mutsumi Asano, Toshihiro Wada, Yoko Hayasaki-Kajiwara, Takanori Iwasaki, Kenichi Matsumura
Publikováno v:
Bioorganicmedicinal chemistry letters. 68
AMP-activated protein kinase (AMPK) has been shown to play an important role in the beneficial effects of exercise on glucose and lipid metabolism in skeletal muscle and liver. Therefore, activation of AMPK has been proposed as an attractive strategy
Publikováno v:
Organic Letters. 20:6244-6249
Two methods for the synthesis of multisubstituted pyridines are described. In each strategy, a highly reactive vinylallene is generated via an intramolecular propargylic ene reaction in the presence of an azadienophile. Reactions employing ethyl N-(t
Publikováno v:
European Journal of Organic Chemistry. 2011:6553-6557
The effects of electrophiles and solvents on the stereochemistry of electrophilic substitution of a lithiocarbanion generated from (S,E)-1-phenylbut-2-en-1-yl diisopropylcarbamate were examined using various acids and carbon electrophiles. The stereo
Publikováno v:
European Journal of Organic Chemistry. 2010:6643-6650
The effect of solvents and additives on the steric course of [2,3]-Wittig rearrangement of the chiral 1,3-diphenyl-1-propenyloxy-2-propen-1-yl carbanion and its derivatives was examined on the basis of chirality transfer in intramolecular trapping.
Publikováno v:
Chemistry - A European Journal. 15:4663-4666
Don't get trapped: The effect of conjugating electron-withdrawing groups and alpha-anion-stabilizing heteroatom substituents on configurational stability of chiral carbanions through a double bond was examined on the basis of extent of chirality tran
Autor:
Masatoshi Kawahata, Kei Takeda, Hidaka Ikemoto, Kentaro Yamaguchi, Tomo Takegawa, Michiko Sasaki
Publikováno v:
ChemInform. 43
α-Chiral nitrile carbanions generated by deprotonation of enantioenriched O-carbamoyl cyanohydrins (I) are trapped in situ with ethyl cyanoformate (II) to give corresponding ester derivatives (III) in high yields and good enantioselectivity.
Publikováno v:
ChemInform. 41
Autor:
Tomo Takegawa, Hidaka Ikemoto, Kentaro Yamaguchi, Michiko Sasaki, Kei Takeda, Masatoshi Kawahata
Publikováno v:
Chemical Communications. 48:2897
An α-chiral nitrile carbanion generated by deprotonation of enantioenriched O-carbamoyl cyanohydrin was trapped in situ with ethyl cyanoformate to give the corresponding ester derivative in 92% yield and 90 : 10 er, providing the first example of tr