The Synergistic Effects of the Glutathione Precursor, NAC and First-Line Antibiotics in the Granulomatous Response Against Mycobacterium tuberculosis

Autor: Garrett Teskey, Ruoqiong Cao, Hicret Islamoglu, Albert Medina, Chaya Prasad, Ramaa Prasad, Airani Sathananthan, Marcel Fraix, Selvakumar Subbian, Li Zhong, Vishwanath Venketaraman

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Mycobacterium tuberculosis (M. tb), the causative bacterial agent responsible for tuberculosis (TB) continues to afflict millions of people worldwide. Although the human immune system plays a critical role in containing M. tb infection, elimination p

Externí odkaz: https://doaj.org/article/764ab95d836c4002ada5638c6c88d42d

The preclinical candidate indole-2-carboxamide improves immune responses to Mycobacterium tuberculosis infection in healthy subjects and individuals with type 2 diabetes

Autor: Oluseye K. Onajole, Karo Gyurjian, Airani Sathananthan, Rachel Abrahem, Li Zhong, William R. Bishai, Hicret Islamoglu, Vishwanath Venketaraman, Jozef Stec, Shichun Lun, Garrett Teskey, Alan P. Kozikowski, Ruoqiong Cao, Marcel Fraix

Publikováno v: International Microbiology. 23:161-170

A novel group of agents known as the indole-2-carboxamides (often referred to as indoleamides) have been shown to demonstrate high antimycobacterial activity. Studies have demonstrated that the best indoleamides possess desirable ADME/Tox properties,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80685ee7a2997a6b140b70457b6d03e5
https://doi.org/10.1007/s10123-019-00086-0

Flavonoid Mixture Inhibits Mycobacterium tuberculosis Survival and Infectivity

Autor: Garrett Teskey, David C. Nieman, Myra Gutierrez, Marcel Fraix, Airani Sathananthan, Ruoqiong Cao, Vishwanath Venketaraman, Hicret Islamoglu, Shalok Munjal, Oscar Salaiz

Publikováno v: Molecules, Vol 24, Iss 5, p 851 (2019)
Molecules
Volume 24
Issue 5

Background: Flavonoids have been shown to exert anti-pathogenic potential, but few studies have investigated their effects on Mycobacterium tuberculosis (Mtb) infectivity. We hypothesized that a flavonoid mixture would have a favorable influence on c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c75b7679adfb0f550c73430e291e99
https://www.mdpi.com/1420-3049/24/5/851

Glutathione as a Marker for Human Disease

Autor: Garrett, Teskey, Rachel, Abrahem, Ruoqiong, Cao, Karo, Gyurjian, Hicret, Islamoglu, Mariana, Lucero, Andrew, Martinez, Erik, Paredes, Oscar, Salaiz, Brittanie, Robinson, Vishwanath, Venketaraman

Publikováno v: Advances in clinical chemistry. 87

Glutathione (GSH), often referred to as "the master antioxidant," participates not only in antioxidant defense systems, but many metabolic processes, and therefore its role cannot be overstated. GSH deficiency causes cellular risk for oxidative damag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c1d67574685fdc9616cb4f68b470a89c
https://pubmed.ncbi.nlm.nih.gov/30342710

Effects of ReadiSorb L-GSH in Altering Granulomatous Responses against Mycobacterium tuberculosis Infection

Autor: John K. Chan, Hicret Islamoglu, Airani Sathananthan, Garrett Teskey, Sebastian Lucar, Vishwanath Venketaraman, Ruoqiong Cao, Marcel Fraix, Karo Gyurjian

Publikováno v: Journal of Clinical Medicine, Vol 7, Iss 3, p 40 (2018)
Journal of Clinical Medicine
Journal of Clinical Medicine; Volume 7; Issue 3; Pages: 40

Mycobacterium tuberculosis (M. tb), a rod-shaped acid-fast bacterium, is the causative agent of tuberculosis (TB). TB remains one of the leading causes of morbidity and mortality worldwide. Additionally, approximately one-third of the world’s popul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f39165cd7c9013957b11ca30e107ac
http://www.mdpi.com/2077-0383/7/3/40