Multicellular membranes as an in vitro model for extravascular diffusion in tumours

Autor: Cowan, D. S., Hicks, K. O., Wilson, W. R.

Efficient extravascular diffusion is a critical requirement for hypoxic cell radiosensitisers, bioreductive drugs and hypoxic cell markers that must reach cells distant from functional blood vessels in tumours. The diffusion of simple nitroimidazoles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6158be2e9b60ab256a100c80b686327a
https://europepmc.org/articles/PMC2149990/

Extravascular Transport of Drugs in Tumor Tissue:  Effect of Lipophilicity on Diffusion of Tirapazamine Analogues in Multicellular Layer Cultures

Autor: Pruijn, F. B., Sturman, J. R., Liyanage, H. D. S., Hicks, K. O., Hay, M. P., Wilson, W. R.

Publikováno v: Journal of Medicinal Chemistry; February 2005, Vol. 48 Issue: 4 p1079-1087, 9p

Extravascular Diffusion of Tirapazamine: Effect of Metabolic Consumption Assessed Using the Multicellular Layer Model

Autor: Hicks, K. O., Fleming, Y., Slim, B. G., Koch, C. J., Wilson, W. R.

Publikováno v: International Journal of Radiation, Oncology, Biology, Physics; 1998, Vol. 42 Issue: 3 p641-650, 10p

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Therapeutic targeting of the hypoxic tumour microenvironment.

Autor: Singleton DC; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand., Macann A; Auckland City Hospital, Auckland, New Zealand., Wilson WR; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. wr.wilson@auckland.ac.nz.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand. wr.wilson@auckland.ac.nz.

Publikováno v: Nature reviews. Clinical oncology [Nat Rev Clin Oncol] 2021 Dec; Vol. 18 (12), pp. 751-772. Date of Electronic Publication: 2021 Jul 29.