Zobrazeno 1 - 10
of 203
pro vyhledávání: '"Hicham Drissi"'
Publikováno v:
eLife, Vol 13 (2024)
Bone remodeling is a complex process involving the coordinated actions of osteoblasts and osteoclasts to maintain bone homeostasis. While the influence of osteoblasts on osteoclast differentiation is well established, the reciprocal regulation of ost
Externí odkaz:
https://doaj.org/article/ffb49cccfb36490e856375467ec115c0
Differential efficacy of two small molecule PHLPP inhibitors to promote nucleus Pulposus cell health
Autor:
Changli Zhang, Madeleine D. Gordon, Katherine M. Joseph, Martha E. Diaz‐Hernandez, Hicham Drissi, Svenja Illien‐Jünger
Publikováno v:
JOR Spine, Vol 7, Iss 1, Pp n/a-n/a (2024)
Abstract Background Intervertebral disc (IVD) degeneration is associated with chronic back pain. We previously demonstrated that the phosphatase pleckstrin homology domain and leucine‐rich repeat protein phosphatase (PHLPP) 1 was positively correla
Externí odkaz:
https://doaj.org/article/34e73a6527424dadbeee7ad7f80a7222
Autor:
Sergio Ramirez-Perez, Rushi Vekariya, Surabhi Gautam, Itzel Viridiana Reyes-Perez, Hicham Drissi, Pallavi Bhattaram
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-15 (2023)
Abstract Background Dimerization of the myeloid differentiation primary response 88 protein (MyD88) plays a pivotal role in the exacerbated response to innate immunity-dependent signaling in rheumatoid arthritis (RA). ST2825 is a highly specific inhi
Externí odkaz:
https://doaj.org/article/0c3f45e445064769a1e48daf8b3677c3
Publikováno v:
Bone Reports, Vol 19, Iss , Pp 101678- (2023)
Externí odkaz:
https://doaj.org/article/59de43f756164504b96302ea1e3ee7c0
Autor:
Nazir M. Khan, Martha E. Diaz-Hernandez, William N. Martin, Bhakti Patel, Samir Chihab, Hicham Drissi
Publikováno v:
PeerJ, Vol 11, p e16553 (2023)
Background Osteoarthritis (OA) is a debilitating joints disease affecting millions of people worldwide. As OA progresses, chondrocytes experience heightened catabolic activity, often accompanied by alterations in the extracellular environment’s osm
Externí odkaz:
https://doaj.org/article/21f826ef7df743389e7ec3a65070d744
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 3751 (2024)
Fracture healing is a complex series of events that requires a local inflammatory reaction to initiate the reparative process. This inflammatory reaction is important for stimulating the migration and proliferation of mesenchymal progenitor cells fro
Externí odkaz:
https://doaj.org/article/7123fe7cc97740f99fdc0737ce94b970
Publikováno v:
Bio-Protocol, Vol 13, Iss 21 (2023)
Induced pluripotent stem cells (iPSCs) generated from human sources are valuable tools for studying skeletal development and diseases, as well as for potential use in regenerative medicine for skeletal tissues such as articular cartilage. To successf
Externí odkaz:
https://doaj.org/article/e88ec61f955f4879af32ea3e43ea0619
Publikováno v:
Bio-Protocol, Vol 13, Iss 22 (2023)
Human induced pluripotent stem cells (hiPSCs) hold immense promise in regenerative medicine as they can differentiate into various cell lineages, including adipocytes, osteoblasts, and chondrocytes. Precisely guiding hiPSC-derived mesenchymal progeni
Externí odkaz:
https://doaj.org/article/ddc0c6a2685a4800bfd59592800dfe7a
Autor:
Sreedhara Sangadala, Chi Heon Kim, Lorenzo M Fernandes, Pooja Makkar, George R Beck, Scott D Boden, Hicham Drissi, Steven M Presciutti
Publikováno v:
eLife, Vol 12 (2023)
Background: The clinical healing environment after a posterior spinal arthrodesis surgery is one of the most clinically challenging bone-healing environments across all orthopedic interventions due to the absence of a contained space and the need to
Externí odkaz:
https://doaj.org/article/f938d673b72c40d2acd5d55d22983de8
Publikováno v:
Genes and Diseases, Vol 9, Iss 4, Pp 1074-1085 (2022)
Intervertebral disc degeneration is the main contributor to low back pain, now the leading cause of disability worldwide. Gene transfer, either in a therapeutic attempt or in basic research to understand the mechanisms of disc degeneration, is a fasc
Externí odkaz:
https://doaj.org/article/159c8118ee634a7fb57b8cf99296eea1