Výsledky vyhledávání - "Hibbs Jr, J. B."

Nitric oxide synthesis contributes to IL-2-induced antitumor responses against intraperitoneal Meth A tumor

Autor: Yim, C. -Y, Mcgregor, J. R., Kwon, O. -D, Bastian, N. R., Rees, M., Mori, M., Hibbs Jr, J. B., Wolfram Samlowski

Publikováno v: Scopus-Elsevier

IL-2 therapy is a potent inductive stimulus for nitric oxide (NO.) synthesis in mice and humans. It is not yet clear whether NO. can contribute to IL-2-induced therapeutic responses. The murine skin cancer Meth A is relatively resistant to lymphokine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7140e70d6f3fba3182b25e0fb68e085
https://doi.org/10.4049/jimmunol.155.9.4382

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L-arginine-dependent macrophage effector functions inhibit metabolic activity of Mycobacterium leprae

Autor: Adams, L. B., Scott Franzblau, Vavrin, Z., Hibbs Jr, J. B., Krahenbuhl, J. L.

Publikováno v: Scopus-Elsevier

Recently, L-arginine has been shown to be a necessary substrate for murine-activated macrophage-mediated tumor cytostasis and microbiostasis of certain fungi, bacteria, and intracellular protozoa. We report here the effects of the L-arginine-dependen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4b7536db9d571418ef1b22288ffbb5
https://doi.org/10.4049/jimmunol.147.5.1642

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Use of N-acetyl cysteine to increase intracellular glutathione during the induction of antitumor responses by IL-2

Autor: Yim, C. -Y, Hibbs Jr, J. B., Mcgregor, J. R., Galinsky, R. E., Wolfram Samlowski

Publikováno v: Scopus-Elsevier

IL-2 therapy can induce marked oxidative stress via reactive oxygen and nitrogen intermediates. Glutathione, the major intracellular reductant, may become rate limiting to cytotoxic lymphocyte activation and proliferation under these circumstances. N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e35ff545e339ec50e7d6b4b3f180b3
http://www.scopus.com/inward/record.url?eid=2-s2.0-0028352803&partnerID=MN8TOARS

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Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism

Autor: Shawn J. Green, Meltzer, M. S., Hibbs Jr, J. B., Nacy, C. A.

Publikováno v: Scopus-Elsevier

Macrophages infected with amastigotes of Leishmania major and treated with IFN-gamma in vitro develop potent antimicrobial activities that eliminate the intracellular parasite. This antileishmanial activity was suppressed in a dose dependent fashion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b09eec9a1ee9925cb85b0f3ed23396b6
http://www.scopus.com/inward/record.url?eid=2-s2.0-0025191159&partnerID=MN8TOARS

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