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Chemical and physical characterization of remotely loaded bupivacaine liposomes: comparison between large multivesicular vesicles and small unilamellar vesicles

Autor: Hiba Kanaan, Rivka Cohen, Yechezkel Barenholz, Ariel Steiner

Publikováno v: Journal of materials chemistry. B. 1(36)

Large multivesicular liposomes (LMVV) remotely loaded with bupivacaine (Bupisome) were previously demonstrated to be a stable, long-acting local anesthetic. We demonstrate that this is not the case for small unilamellar vesicles (SUV) of the same lip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d1f51e1cca05fc4c80439725912b9c
https://pubmed.ncbi.nlm.nih.gov/32261205

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Prolonged analgesia from Bupisome and Bupigel formulations: from design and fabrication to improved stability

Autor: Yechezkel Barenholz, Hiba Kanaan, Rivka Cohen, Gilbert J. Grant

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 160(2)

There is a compelling need for an ultralong-acting local anesthetic. Previously, we demonstrated in mice and humans that encapsulation of bupivacaine into large multivesicular liposomes (Bupisome) prolongs drug residence time and analgesic duration a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eaa2b059b74c7fbefc038da8fbf0cce
https://pubmed.ncbi.nlm.nih.gov/22233969

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