Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hiba Ahmad Zahreddine"'
Autor:
Hiba Ahmad Zahreddine, Biljana Culjkovic-Kraljacic, Audrey Emond, Filippa Pettersson, Ronald Midura, Mark Lauer, Sonia Del Rincon, Valbona Cali, Sarit Assouline, Wilson H Miller, Vincent Hascall, Katherine LB Borden
Publikováno v:
eLife, Vol 6 (2017)
The microenvironment provides a functional substratum supporting tumour growth. Hyaluronan (HA) is a major component of this structure. While the role of HA in malignancy is well-defined, the mechanisms driving its biosynthesis in cancer are poorly u
Externí odkaz:
https://doaj.org/article/347003db749b4cfea541aa4f5080caa2
Autor:
Sarit Assouline, Biljana Culjkovic-Kraljacic, Julie Bergeron, Stephen Caplan, Eftihia Cocolakis, Caroline Lambert, Cara J. Lau, Hiba Ahmad Zahreddine, Wilson H. Miller, Katherine L. B. Borden
Publikováno v:
Haematologica, Vol 100, Iss 1 (2015)
Externí odkaz:
https://doaj.org/article/4b334c17ad364ea895bc5372c0d308dd
Autor:
Katherine L. B. Borden, Hiba Ahmad Zahreddine, Jadwiga Gasiorek, Jean Duchaine, Biljana Culjkovic-Kraljacic
Publikováno v:
ACS chemical biology. 14(3)
Cancer therapies are plagued by resistance. Previously, we discovered a novel form of cancer drug resistance where the Glioma-associated protein 1 (GLI1) elevates UGT1A glucuronidation enzymes, thereby glucuronidating cytarabine and ribavirin, leadin
Autor:
Michael J. Osborne, Hiba Ahmad Zahreddine, Katherine L. B. Borden, Laurent Volpon, Luciana Coutinho de Oliveira
Drug resistance is a major cause of cancer-related mortality. Glucuronidation of drugs via elevation of UDP-glucuronosyltransferases (UGT1As) correlates with clinical resistance. The nine UGT1A family members have broad substrate specificities attrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a74679733456f3fa0d4eb6ebe4ae5e
https://europepmc.org/articles/PMC6331242/
https://europepmc.org/articles/PMC6331242/
Autor:
Sarit Assouline, Filippa Pettersson, Biljana Culjkovic-Kraljacic, Valbona Cali, Wilson H. Miller, Vincent C. Hascall, Sonia V. del Rincón, Hiba Ahmad Zahreddine, Ronald J. Midura, Mark E. Lauer, Katherine L. B. Borden, Audrey Emond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::042014190ae42178dd7be8eab29d2535
https://doi.org/10.7554/elife.29830.018
https://doi.org/10.7554/elife.29830.018
Publikováno v:
Clinical Cancer Research. 21:2207-2210
Drug resistance remains a major impediment in the development of durable cancer therapies. Studies in acute myelogenous leukemia (AML) patients revealed a new form of multidrug resistance. Here, increased glioma-associated protein GLI1 leads to eleva
Autor:
Rebecca Goldstein, Paola Ghione, Katherine L. B. Borden, Biljana Culjkovic-Kraljacic, Hiba Ahmad Zahreddine, Jayeshkumar Patel, Rodolfo Machiorlatti, Akanksha Verma, Tony Taldone, Fabrizio Tabbò, Rossella Marullo, Marcello Gaudiano, Tharu M. Fernando, Olivier Elemento, Giorgio Inghirami, Gabriela Chiosis, Shao Ning Yang, Marco Ladetto, Ari Melnick, Leandro Cerchietti, Nieves Calvo-Vidal
Aggressive double- and triple-hit (DH/TH) diffuse large B-cell lymphomas (DLBCLs) feature activation of Hsp90 stress pathways. Herein, we show that Hsp90 controls posttranscriptional dynamics of key messenger RNA (mRNA) species including those encodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5148cf10b886520b8b9565121e54eaf4
https://europepmc.org/articles/PMC4760090/
https://europepmc.org/articles/PMC4760090/
Autor:
Julie Bergeron, Hiba Ahmad Zahreddine, Eftihia Cocolakis, Katherine L. B. Borden, Sarit Assouline, Biljana Culjkovic-Kraljacic, Cara J. Lau, Caroline Lambert, Wilson H. Miller, Stephen Caplan
The molecular heterogeneity of acute myeloid leukemia (AML) underlies the wide variation in responses to standard therapy. This heterogeneity occurs at multiple regulatory steps affecting cell survival and proliferation.[1][1] We identified overexpre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6dfe67b72d45a63625979c94f29fae
https://europepmc.org/articles/PMC4281321/
https://europepmc.org/articles/PMC4281321/
Autor:
Biljana Kraljacic-Culjkovic, Mark E. Lauer, Ronald J. Midura, Craig Jordan, Lucy Skrabanek, Hiba Ahmad Zahreddine, Valbona Cali, Leandro Cerchietti, Nabilah Khan, Vincent C. Hascall
Publikováno v:
Cancer Research. 77:4898-4898
Formation of cell surface protrusions has long been associated with tumor cell migration, metastasis & bone marrow homing & retention. It was shown that increased expression of endogenous or exogenous hyaluronic acid synthesizing enzyme 3 (HAS3) indu
Resistance to chemotherapy is a major problem facing cancer treatment. Understanding the molecular basis for drug resistance has lagged behind our understanding and identification of new pathways to target. Even early on in treatment, patients can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b79169f9fc0442aee0ee11c12f0fbd1
https://europepmc.org/articles/PMC4614680/
https://europepmc.org/articles/PMC4614680/