Ranking parameters driving siring success during sperm competition in the North African houbara bustard

Autor: Gabriele Sorci, Hiba Abi Hussein, Gwènaëlle Levêque, Michel Saint Jalme, Frédéric Lacroix, Yves Hingrat, Loïc Lesobre

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)

Using data collected over several years, Sorci et al. take a machine learning approach to rank parameters linked to sperm competition outcomes following artificial insemination of captive North African houbara bustard females.

Externí odkaz: https://doaj.org/article/a4680092033d4865b908bb0dbeca6f01

Molecular Dynamics Simulations of Influenza A Virus NS1 Reveal a Remarkably Stable RNA-Binding Domain Harboring Promising Druggable Pockets

Autor: Hiba Abi Hussein, Colette Geneix, Camille Cauvin, Daniel Marc, Delphine Flatters, Anne-Claude Camproux

Publikováno v: Viruses, Vol 12, Iss 5, p 537 (2020)

The non-structural protein NS1 of influenza A viruses is considered to be the major antagonist of the interferon system and antiviral defenses of the cell. It could therefore represent a suitable target for novel antiviral strategies. As a first step

Externí odkaz: https://doaj.org/article/6f82864053904ca4979a0e0f803b363d

Global vision of druggability issues: applications and perspectives

Autor: Michel Petitjean, Anne-Claude Camproux, Alexandre Borrel, Hiba Abi Hussein, Delphine Flatters, Colette Geneix

Publikováno v: Drug Discovery Today Biosilico
Drug Discovery Today Biosilico, Elsevier, 2017, 22 (2), pp.404-415. ⟨10.1016/j.drudis.2016.11.021⟩

International audience; During the preliminary stage of a drug discovery project, the lack of druggability information and poor target selection are the main causes of frequent failures. Elaborating on accurate computational druggability prediction m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52bfb1b1c5a883306882d12988f5aef
https://doi.org/10.1016/j.drudis.2016.11.021

Molecular Dynamics Simulations of Influenza A Virus NS1 Reveal a Remarkably Stable RNA-Binding Domain Harboring Promising Druggable Pockets

Autor: Camille Cauvin, Delphine Flatters, Colette Geneix, Anne-Claude Camproux, Hiba Abi Hussein, Daniel Marc

Publikováno v: Viruses
Viruses, MDPI, 2020, 12 (5), 17 p. ⟨10.3390/v12050537⟩
Volume 12
Issue 5
Viruses, Vol 12, Iss 537, p 537 (2020)
Viruses, 2020, 12 (5), 17 p. ⟨10.3390/v12050537⟩

The non-structural protein NS1 of influenza A viruses is considered to be the major antagonist of the interferon system and antiviral defenses of the cell. It could therefore represent a suitable target for novel antiviral strategies. As a first step

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93fdcdadbb5bdab027f87b717199a1c5
https://doi.org/10.3390/v12050537

PockDrug-Server : a new web server for predicting pocket druggability on holo and apo proteins

Autor: Alexandre Borrel, Leslie Regad, Colette Geneix, Hiba Abi Hussein, Michel Petitjean, Anne-Claude Camproux

Publikováno v: Nucleic Acids Research

Predicting protein pocket's ability to bind drug-like molecules with high affinity, i.e. druggability, is of major interest in the target identification phase of drug discovery. Therefore, pocket druggability investigations represent a key step of co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1038c30b3fa26f02ad21aef926374aa
http://hdl.handle.net/10138/161953