Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Hianara A. Bustamante"'
1
Akademický článek
An Intrinsic Host Defense against HSV-1 Relies on the Activation of Xenophagy with the Active Clearance of Autophagic Receptors
Autor: Camila Pino-Belmar, Rayén Aguilar, Guillermo E. Valenzuela-Nieto, Viviana A. Cavieres, Cristóbal Cerda-Troncoso, Valentina C. Navarrete, Paula Salazar, Patricia V. Burgos, Carola Otth, Hianara A. Bustamante
Publikováno v: Cells, Vol 13, Iss 15, p 1256 (2024)
Autophagy engulfs cellular components in double-membrane-bound autophagosomes for clearance and recycling after fusion with lysosomes. Thus, autophagy is a key process for maintaining proteostasis and a powerful cell-intrinsic host defense mechanism,
Externí odkaz: https://doaj.org/article/ac44167cac1a4a3fbfa4e0f9e70127fe
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2
Akademický článek
Negative Modulation of Macroautophagy by Stabilized HERPUD1 is Counteracted by an Increased ER-Lysosomal Network With Impact in Drug-Induced Stress Cell Survival
Autor: Gabriela Vargas, Omar Cortés, Eloisa Arias-Muñoz, Sergio Hernández, Cristobal Cerda-Troncoso, Laura Hernández, Alexis E. González, Michael H. Tatham, Hianara A. Bustamante, Claudio Retamal, Jorge Cancino, Manuel Varas-Godoy, Ronald T. Hay, Alejandro Rojas-Fernández, Viviana A. Cavieres, Patricia V. Burgos
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Macroautophagy and the ubiquitin proteasome system work as an interconnected network in the maintenance of cellular homeostasis. Indeed, efficient activation of macroautophagy upon nutritional deprivation is sustained by degradation of preexisting pr
Externí odkaz: https://doaj.org/article/bd76765fe7a64b528c6ac6d42af58390
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3
Akademický článek
Interplay Between the Autophagy-Lysosomal Pathway and the Ubiquitin-Proteasome System: A Target for Therapeutic Development in Alzheimer’s Disease
Autor: Hianara A. Bustamante, Alexis E. González, Cristobal Cerda-Troncoso, Ronan Shaughnessy, Carola Otth, Andrea Soza, Patricia V. Burgos
Publikováno v: Frontiers in Cellular Neuroscience, Vol 12 (2018)
Alzheimer’s disease (AD) is the most common cause of age-related dementia leading to severe irreversible cognitive decline and massive neurodegeneration. While therapeutic approaches for managing symptoms are available, AD currently has no cure. AD
Externí odkaz: https://doaj.org/article/d9aff8b30736479b82f14b7327cfa287
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4
Novel insights into the non-canonical roles of PSMD14/POH1/Rpn11 in proteostasis and in the modulation of cancer progression
Autor: Hianara A. Bustamante, Nicolás Albornoz, Eugenia Morselli, Andrea Soza, Patricia V. Burgos
Publikováno v: Cellular signalling. 101
PSMD14/POH1/Rpn11 plays a crucial role in cellular homeostasis. PSMD14 is a structural subunit of the lid subcomplex of the proteasome 19S regulatory particle with constitutive deubiquitinase activity. Canonically, PSMD14 removes the full ubiquitin c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c8bc8ab830ad6395496fd280051806
https://pubmed.ncbi.nlm.nih.gov/36241058
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6
Autophagosomes cooperate in the degradation of intracellular C‐terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway
Autor: Alexis E González, Yunan C Januário, Gonzalo A. Mardones, Vanessa C. Muñoz, Viviana A Cavieres, Patricia V. Burgos, Hianara A. Bustamante, Claudio Hetz, Luis L. P. daSilva, Ibeth González, Alejandro Rojas-Fernandez, Víctor-Hugo Cornejo, Ronald T. Hay
Publikováno v: The Faseb Journal
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Brain regions affected by Alzheimer disease (AD) display well-recognized early neuropathologic features in the endolysosomal and autophagy systems of neurons, including enlargement of endosomal compartments, progressive accumulation of autophagic vac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8143301e35d6e40d10818c78944c32af
https://doi.org/10.1096/fj.201600713r
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7
Cellular Responses to Proteasome Inhibition: Molecular Mechanisms and Beyond
Autor: Patricia Burgos, Andrea Soza, Nicolas Albornoz, Hianara A. Bustamante
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 14, p 3379 (2019)
Proteasome inhibitors have been actively tested as potential anticancer drugs and in the treatment of inflammatory and autoimmune diseases. Unfortunately, cells adapt to survive in the presence of proteasome inhibitors activating a variety of cell re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ec4430bfae10a8935893ef89ba87f5
https://pubmed.ncbi.nlm.nih.gov/31295808
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8
The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport
Autor: Alejandro Rojas, Ronald T. Hay, G. Kausel, Guillermo Valenzuela, Alexis E González, Karina Cereceda, Patricia V. Burgos, Eloisa Arias, Jorge Cancino, Yorka Cheuquemilla, Hianara A. Bustamante, Cristóbal Cerda-Troncoso, Sergio Hernández, Susanne Bandau, Bredford Kerr, Andrea Soza, Gonzalo A. Mardones
Publikováno v: Cells
Volume 9
Issue 3
Cells, Vol 9, Iss 3, p 777 (2020)
Ubiquitination regulates several biological processes, however the role of specific members of the ubiquitinome on intracellular membrane trafficking is not yet fully understood. Here, we search for ubiquitin-related genes implicated in protein membr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a584a105d13cf25c4986d981469472
https://doi.org/10.3390/cells9030777
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9
Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein
Autor: Alexis E, González, Vanessa C, Muñoz, Viviana A, Cavieres, Hianara A, Bustamante, Víctor-Hugo, Cornejo, Yunan C, Januário, Ibeth, González, Claudio, Hetz, Luis L, daSilva, Alejandro, Rojas-Fernández, Ronald T, Hay, Gonzalo A, Mardones, Patricia V, Burgos
Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31(6)
Brain regions affected by Alzheimer disease (AD) display well-recognized early neuropathologic features in the endolysosomal and autophagy systems of neurons, including enlargement of endosomal compartments, progressive accumulation of autophagic vac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f01aceaf5b864a50075d95e26b63164
https://pubmed.ncbi.nlm.nih.gov/28254759
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10
Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy
Autor: Nibaldo C. Inestrosa, Viviana A Cavieres, Claudia P. Yefi, Alexis E González, Carola Otth, Cheril Tapia-Rojas, Carlos B. Gonzalez, Rafael R. Barraza, Hianara A. Bustamante, María-José Barrera, Gonzalo A. Mardones, Vanessa C. Muñoz, Patricia V. Burgos
Publikováno v: PLoS ONE
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
PLoS ONE, Vol 10, Iss 8, p e0136313 (2015)
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) peptide. We have previously shown that the compound tetrahydrohyperforin (IDN5706) prevents accumulation of Aβ species in an in vivo model
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65054b25eb206fb8834ce4295ea18378
https://pubmed.ncbi.nlm.nih.gov/26308941
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