Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Hiam A. Valencia"'
Autor:
Michaela M. Novakovic, Kirill S. Korshunov, Rogan A. Grant, Megan E. Martin, Hiam A. Valencia, G. R. Scott Budinger, Jelena Radulovic, Murali Prakriya
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Astrocytes contribute to brain inflammation in neurological disorders but the molecular mechanisms controlling astrocyte reactivity and their relationship to neuroinflammatory endpoints are complex and poorly understood. In this study, we as
Externí odkaz:
https://doaj.org/article/126b49e946bc446587919a74f95203cf
Autor:
Wenxia Wang, Swarna Bale, Jun Wei, Bharath Yalavarthi, Dibyendu Bhattacharyya, Jing Jing Yan, Hiam Abdala-Valencia, Dan Xu, Hanshi Sun, Roberta G. Marangoni, Erica Herzog, Sergejs Berdnikovs, Stephen D. Miller, Amr H. Sawalha, Pei-Suen Tsou, Kentaro Awaji, Takashi Yamashita, Shinichi Sato, Yoshihide Asano, Chinnaswamy Tiruppathi, Anjana Yeldandi, Bettina C. Schock, Swati Bhattacharyya, John Varga
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
A20 gene variants are linked with systemic sclerosis (SS), but the mechanisms are unclear. Here, the authors show that A20 expression is reduced in SS skin and lungs, that its ablation in mice induces SS, and that show that fibrosis can be ameliorate
Externí odkaz:
https://doaj.org/article/b780d1905dd3456085e57175c8dc1c29
Autor:
Suganya Sivagurunathan, Amir Vahabikashi, Haiqian Yang, Jun Zhang, Kelly Vazquez, Dhivyaa Rajasundaram, Yuliya Politanska, Hiam Abdala-Valencia, Jacob Notbohm, Ming Guo, Stephen A. Adam, Robert D. Goldman
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Vimentin is a Type III intermediate filament (VIF) cytoskeletal protein that regulates the mechanical and migratory behavior of cells. Its expression is considered to be a marker for the epithelial to mesenchymal transition (EMT) that takes place in
Externí odkaz:
https://doaj.org/article/77d566af8a374e9e9a874adf3df64d39
Autor:
Clarissa M. Koch, Andrew D. Prigge, Leah Setar, Kishore R. Anekalla, Hahn Chi Do-Umehara, Hiam Abdala-Valencia, Yuliya Politanska, Avani Shukla, Jairo Chavez, Grant R. Hahn, Bria M. Coates
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundRespiratory syncytial virus (RSV) can cause life-threatening respiratory failure in infants. We sought to characterize the local host response to RSV infection in the nasal mucosa of infants with critical bronchiolitis and to identify early
Externí odkaz:
https://doaj.org/article/ae3cff469f85491bb96166479a22cb0a
Autor:
Abhineet M. Sharma, Robert Birkett, Erika T. Lin, Linda M. Ernst, William A. Grobman, Suchitra Swaminathan, Hiam Abdala-Valencia, Alexander V. Misharin, Elizabeth T. Bartom, Karen K. Mestan
Publikováno v:
JCI Insight, Vol 7, Iss 11 (2022)
The placenta is the primary organ for immune regulation, nutrient delivery, gas exchange, protection against environmental toxins, and physiologic perturbations during pregnancy. Placental inflammation and vascular dysfunction during pregnancy are as
Externí odkaz:
https://doaj.org/article/da267acb9d184c378de5cf0f7c1494ae
Autor:
Justin E. Ideozu, Vittobai Rangaraj, Hiam Abdala-Valencia, Xi Zhang, Manoj Kandpal, Marc A. Sala, Ramana V. Davuluri, Hara Levy
Publikováno v:
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-16 (2019)
Abstract Background In cystic fibrosis (CF), impaired immune cell responses, driven by the dysfunctional CF transmembrane conductance regulator (CFTR) gene, may determine the disease severity but clinical heterogeneity remains a major therapeutic cha
Externí odkaz:
https://doaj.org/article/b38291cc096a40c9a4af6e783d83ea7f
Autor:
Luisa Morales-Nebreda, Kathryn A. Helmin, Manuel A. Torres Acosta, Nikolay S. Markov, Jennifer Yuan-Shih Hu, Anthony M. Joudi, Raul Piseaux-Aillon, Hiam Abdala-Valencia, Yuliya Politanska, Benjamin D. Singer
Publikováno v:
JCI Insight, Vol 6, Iss 6 (2021)
Regulatory T (Treg) cells orchestrate resolution and repair of acute lung inflammation and injury after viral pneumonia. Compared with younger patients, older individuals experience impaired recovery and worse clinical outcomes after severe viral inf
Externí odkaz:
https://doaj.org/article/41bdc7d401fc4fa2be015bcf8b4b0bb6
Autor:
Chitaru Kurihara, Emilia Lecuona, Qiang Wu, Wenbin Yang, Félix L. Núñez-Santana, Mahzad Akbarpour, Xianpeng Liu, Ziyou Ren, Wenjun Li, Melissa Querrey, Sowmya Ravi, Megan L. Anderson, Emily Cerier, Haiying Sun, Megan E. Kelly, Hiam Abdala-Valencia, Ali Shilatifard, Thalachallour Mohanakumar, G.R. Scott Budinger, Daniel Kreisel, Ankit Bharat
Publikováno v:
JCI Insight, Vol 6, Iss 6 (2021)
Primary graft dysfunction (PGD) is the predominant cause of early graft loss following lung transplantation. We recently demonstrated that donor pulmonary intravascular nonclassical monocytes (NCM) initiate neutrophil recruitment. Simultaneously, hos
Externí odkaz:
https://doaj.org/article/cb3ce52f508540b4bd16d407b8b2ff90
Autor:
Sarah A Taylor, Shang-Yang Chen, Gaurav Gadhvi, Liang Feng, Kyle D Gromer, Hiam Abdala-Valencia, Kiwon Nam, Salina T Dominguez, Anna B Montgomery, Paul A Reyfman, Lorena Ostilla, Joshua B Wechsler, Carla M Cuda, Richard M Green, Harris Perlman, Deborah R Winter
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0244743 (2021)
Background & aimsLimited understanding of the role for specific macrophage subsets in the pathogenesis of cholestatic liver injury is a barrier to advancing medical therapy. Macrophages have previously been implicated in both the mal-adaptive and pro
Externí odkaz:
https://doaj.org/article/c015eb78f3cb4aa88de1330263a1b31d
Autor:
Thomas Stoeger, Rogan A. Grant, Alexandra C. McQuattie-Pimentel, Kishore R. Anekalla, Sophia S. Liu, Heliodoro Tejedor-Navarro, Benjamin D. Singer, Hiam Abdala-Valencia, Michael Schwake, Marie-Pier Tetreault, Harris Perlman, William E. Balch, Navdeep S. Chandel, Karen M. Ridge, Jacob I. Sznajder, Richard I. Morimoto, Alexander V. Misharin, G. R. Scott Budinger, Luis A. Nunes Amaral
Publikováno v:
Nature Aging. 2:1191-1206
Aging is among the most important risk factors for morbidity and mortality. To contribute toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data from multiple studies. Here, we show that transcript length alone explai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0de44d4d63fdc5bb0ddd8d07ad5d272
https://doi.org/10.1038/s43587-022-00317-6
https://doi.org/10.1038/s43587-022-00317-6