Zobrazeno 1 - 10 of 48 pro vyhledávání: '"Hh, hedgehog"'
1
Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures
Autor: Xin-Ying Ji, Muhammad Farhan Khan, Asim Ur Rehman, Mahnoor Baloch, Lei Qian, Dongdong Wu, Ebenezeri Erasto Ngowi, Nazeer Hussain Khan, Maria Mir
Publikováno v: Journal of Advanced Research, Vol 36, Iss, Pp 223-247 (2022)
Journal of Advanced Research
Graphical abstract
Highlights • Skin cancer is a fatal public health concern rising continuously all over the world. • Several environmental and genetic risk factors are associated with cutaneous carcinogenesis. • Use of nanocarriers for t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4504efcb0df22ab6d14aa8271e9a2d16
https://doi.org/10.1016/j.jare.2021.06.014
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2
Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma
Autor: Wenfu Tan, Huaqian Ding, Xiaohua Liu, Chunyong Ding, Juan Wang, Yalei Li, Ao Zhang, Yu Zhang, Hongchun Liu, Wenjing Huang
Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 488-504 (2021)
Acta Pharmaceutica Sinica. B
Medulloblastoma (MB) is a common yet highly heterogeneous childhood malignant brain tumor, however, clinically effective molecular targeted therapy is lacking. Modulation of hedgehog (HH) signaling by epigenetically targeting the transcriptional fact
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301cde2b3eb755a22e93dd5c8eb925b1
https://doi.org/10.1016/j.apsb.2020.07.007
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3
Recent advances in drug delivery systems for targeting cancer stem cells
Autor: Zhonggao Gao, Wei Huang, Hongxia Duan, Yanhong Liu
Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 55-70 (2021)
Acta Pharmaceutica Sinica. B
Cancer stem cells (CSCs) are a subpopulation of cancer cells with functions similar to those of normal stem cells. Although few in number, they are capable of self-renewal, unlimited proliferation, and multi-directional differentiation potential. In
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa624bee1b295d3b2a8ea11ea5504c8
http://www.sciencedirect.com/science/article/pii/S2211383520307322
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5
Regulation of the Pancreatic Exocrine Differentiation Program and Morphogenesis by Onecut 1/Hnf6Summary
Autor: Maureen Gannon, Peter A. Kropp, Xiaodong Zhu
Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 841-856 (2019)
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims The Onecut 1 transcription factor (Oc1, a.k.a. HNF6) promotes differentiation of endocrine and duct cells of the pancreas; however, it has no known role in acinar cell differentiation. We sought to better understand the role of Oc1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8340f4db90d84f348eeb0763345455be
http://www.sciencedirect.com/science/article/pii/S2352345X19300207
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8
Developing the next generation of graphene-based platforms for cancer therapeutics: The potential role of reactive oxygen species
Autor: Tanveer A. Tabish, Shaowei Zhang, Paul G. Winyard
Publikováno v: Redox Biology
Redox Biology, Vol 15, Iss C, Pp 34-40 (2018)
Graphene has a promising future in applications such as disease diagnosis, cancer therapy, drug/gene delivery, bio-imaging and antibacterial approaches owing to graphene's unique physical, chemical and mechanical properties alongside minimal toxicity
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b3b12c807fdcf7ce46e0475c4ee8c8d3
http://europepmc.org/articles/PMC5723279
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9
Hedgehog Signaling Links Chronic Inflammation to Gastric Cancer Precursor LesionsSummary
Autor: Juanita L. Merchant, Lin Ding
Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 2, Pp 201-210 (2017)
Cellular and Molecular Gastroenterology and Hepatology
Since its initial discovery in Drosophila, Hedgehog (HH) signaling has long been associated with foregut development. The mammalian genome expresses 3 HH ligands, with sonic hedgehog (SHH) levels highest in the mucosa of the embryonic foregut. More r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e077df2ac4c1cce99125281189ce77f3
http://www.sciencedirect.com/science/article/pii/S2352345X17300085
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10
Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis
Autor: Kimberly Ha, Lowell Evan Michael, James M. Olson, Jean François Rual, Chiyoko Uchida, Tao Xu, Rork Kuick, Honglai Zhang, Takafumi Uchida, Ashok Srinivasan, Andrzej A. Dlugosz, Sandra Camelo-Piragua, Mariarita Santi, Sriram Venneti, Sung Soo Park
Publikováno v: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 3, Pp 216-225 (2017)
Medulloblastoma is the most common malignant brain tumor in children. Therapeutic approaches to medulloblastoma (combination of surgery, radiotherapy, and chemotherapy) have led to significant improvements, but these are achieved at a high cost to qu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff603e9a0ec594c7c07731b0f37aec8
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