Development and application of an indirect ELISA and nested PCR for the epidemiological analysis of Klebsiella pneumoniae among pigs in China

Autor: Zengshuai Wu, Na Li, Ziheng Li, Jianlong Wang, Mengmeng Liu, Mengzhu Qi, Shaopeng Wei, Tong Wu, Yu Guo, Junhui Zhu, Hexiang Jiang, Ruixue Xue, Changjiang Sun, Xin Feng, Jingmin Gu, Wenyu Han, Fengyang Li, Liancheng Lei

Publikováno v: Frontiers in Microbiology, Vol 14 (2024)

IntroductionKlebsiella pneumoniae (K. pneumoniae) is an important opportunistic and zoonotic pathogen which is associated with many diseases in humans and animals. However, the pathogenicity of K. pneumoniae has been neglected and the prevalence of K

Externí odkaz: https://doaj.org/article/43bb6a624d3a43fd88633e0a1fa8d475

Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity

Autor: Hongtao Liu, Siyu Lei, Li Jia, Xiaojing Xia, Yingying Sun, Hexiang Jiang, Rining Zhu, Shuguang Li, Guanggang Qu, Jingmin Gu, Changjiang Sun, Xin Feng, Wenyu Han, Paul R. Langford, Liancheng Lei

Publikováno v: Veterinary Research, Vol 52, Iss 1, Pp 1-15 (2021)

Abstract Host proteins interacting with pathogens are receiving more attention as potential therapeutic targets in molecular medicine. Streptococcus suis serotype 2 (SS2) is an important cause of meningitis in both humans and pigs worldwide. SS2 Enol

Externí odkaz: https://doaj.org/article/89234c75580e448f8c769c3147236070

Host HSPD1 Translocation from Mitochondria to the Cytoplasm Induced by Streptococcus suis Serovar 2 Enolase Mediates Apoptosis and Loss of Blood–Brain Barrier Integrity

Autor: Tong Wu, Li Jia, Siyu Lei, Hexiang Jiang, Jianan Liu, Na Li, Paul R. Langford, Hongtao Liu, Liancheng Lei

Publikováno v: Cells, Vol 11, Iss 13, p 2071 (2022)

Streptococcus suis serovar 2 (S. suis serovar 2) is a zoonotic pathogen that causes meningitis in pigs and humans, and is a serious threat to the swine industry and public health. Understanding the mechanism(s) by which S. suis serovar 2 penetrates t

Externí odkaz: https://doaj.org/article/e65e1df5a4ea40ab8742cb5e57a9c5cb

Differential Protein Profiling of Cerebrospinal Fluid in Piglets with Severe Meningoencephalitis Caused by Streptococcus suis Type 2 Compared to Controls

Autor: Hongtao Liu, Li Jia, Wenfei Guo, Yingying Sun, Rining Zhu, Shuguang Li, Guanggang Qu, Hexiang Jiang, Junjie Wang, Jingmin Gu, Changjiang Sun, Xin Feng, Wenyu Han, Liancheng Lei

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)

Streptococcus suis serotype 2 (SS2) is a zoonotic pathogen that can cause meningitis both in pigs and in human beings. However, the pathogenesis of central nervous system (CNS) infection caused by SS2 have not yet been elucidated. To find the key mol

Externí odkaz: https://doaj.org/article/e1f1cbe9035744c48fe1d9b6c315862e

Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity

Autor: Guanggang Qu, Hongtao Liu, Li Jia, Paul R. Langford, Hexiang Jiang, Yingying Sun, Changjiang Sun, Xin Feng, Shuguang Li, Rining Zhu, Xiaojing Xia, Wenyu Han, Liancheng Lei, Jingmin Gu, Lei Siyu

Publikováno v: Veterinary Research
Veterinary Research, BioMed Central, 2021, 52 (1), pp.30. ⟨10.1186/s13567-020-00887-6⟩
Veterinary Research, Vol 52, Iss 1, Pp 1-15 (2021)

Host proteins interacting with pathogens are receiving more attention as potential therapeutic targets in molecular medicine. Streptococcus suis serotype 2 (SS2) is an important cause of meningitis in both humans and pigs worldwide. SS2 Enolase (Eno)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97959bdbff4b6b02fd80d28685c09bb8
https://hal.archives-ouvertes.fr/hal-03154460/file/13567_2020_Article_887.pdf