Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Hew Yeng Lai"'
Autor:
Hew Yeng Lai, Stefan Brooks, Laura F. Mendez Luque, Xinyue Chang, Brianna M. Craver, Angela G. Fleischman, Gajalakshmi Ramanathan, Summer Hoang
Publikováno v:
Blood advances, vol 4, iss 2
Thrombosis is a major cause of mortality in patients with myeloproliferative neoplasms (MPNs), though there is currently little to offer patients with MPN beyond aspirin and cytoreductive therapies such as hydroxyurea for primary prevention. Thrombog
Autor:
Michael R. Garbati, Brianna M. Craver, Thanh Kim Nguyen, Hew Yeng Lai, Angela G. Fleischman, Stefan Brooks, Nahideh Haghighi, Sarah J. Morse
Publikováno v:
Blood Advances. 3:122-131
Patients with myeloproliferative neoplasms (MPN) have high levels of inflammatory cytokines, some of which drive many of the debilitating constitutional symptoms associated with the disease and may also promote expansion of the neoplastic clone. We r
Autor:
Angela G. Fleischman, Michael T. Kleinman, Gajalakshmi Ramanathan, Brianna Craver-Hoover, David A. J. Herman, Jane H Chen, Samantha R. Renusch, Rebecca J Arechavala, Hew Yeng Lai
Publikováno v:
Cancers, Vol 12, Iss 2292, p 2292 (2020)
Cancers, vol 12, iss 8
Cancers
Volume 12
Issue 8
Cancers, vol 12, iss 8
Cancers
Volume 12
Issue 8
Electronic cigarettes (E-cigs) generate nicotine containing aerosols for inhalation and have emerged as a popular tobacco product among adolescents and young adults, yet little is known about their health effects due to their relatively recent introd
Autor:
Brianna M Hoover, Hew Yeng Lai, Nitya Mehrota-Venkat, Tiffany Han, Gajalakshmi Ramanathan, Angela G. Fleischman, Tiffany Trieu
Publikováno v:
Blood. 138:3595-3595
An emerging theme among clonal hematopoiesis (CH) associated mutations is that these mutations endow hematopoietic stem cells (HSC) protection from chronic inflammatory stress. Specific inflammatory stressors may select for specific mutants, such tha
Autor:
Simran Bhardwaj, Angela G. Fleischman, Eli M Soyfer, Hew Yeng Lai, Nahid Haghighi, Hellen Nguyen
Publikováno v:
Blood. 138:4926-4926
Introduction A matched "tumor" and germline sample is required to unambiguously identify somatically acquired mutations in the blood or bone marrow of patients with hematologic malignancies or clonal hematopoiesis, particularly when variants of unkno
Publikováno v:
The Journal of Immunology. 204:145.30-145.30
Chronic inflammation is a key feature of myeloproliferative neoplasm (MPN), a hematological malignancy. MPN is characterized acquisition of a somatic mutation in hematopoietic stem cells, most commonly the JAK2V617F mutation, which leads to unrestrai
Autor:
Stefan Brooks, Tiffany Trieu, Angela G. Fleischman, Tiffany Han, Brianna M. Craver, Hew Yeng Lai, Gajalakshmi Ramanathan
Publikováno v:
Blood. 134:4206-4206
Rationale: Chronic inflammation is a key feature of Myeloproliferative Neoplasm (MPN), inflammation drives symptom burden and disease progression. We have found that monocytes from MPN patients persistently produce Tumor Necrosis Factor-alpha (TNF) f
Autor:
Summer Hoang, Hew Yeng Lai, Angela G. Fleischman, Gajalakshmi Ramanathan, Laura F. Mendez Luque, Kenza Elalaoui, Stefan Brooks, Brianna M. Craver
Publikováno v:
Blood. 132:1786-1786
Chronic inflammation is common in MPN and drives disease progression and worsens symptom burden. It has been reported that JAK2V617F hematopoietic stem and progenitor cells (HSPCs) exhibit elevated basal oxidative stress compared to wild-type cells.
Autor:
Jennifer B. H. Martiny, Angela G. Fleischman, Andrew Oliver, Brianna M. Craver, Kenza Elalaoui, Daniel Kim, Claudia Weihe, Stefan Brooks, Katrine Whiteson, Hew Yeng Lai
Publikováno v:
Blood. 132:3051-3051
The human microbiome is composed of trillions of micro-organisms living in symbiosis with the human body. The interest in the microbiome and the clinical impact of its disruption (dysbiosis) has grown exponentially in the past years, especially in th
Autor:
Angela G. Fleischman, Hew Yeng Lai, Samuel B. Luty, Brian J. Druker, Stefan Brooks, Anupriya Agarwal, Thanh Kim Nguyen, Lacey R. Royer, Sarah J. Morse
Publikováno v:
Experimental hematology, vol 44, iss 1
A germline JAK2(V617I)point mutation results in hereditary thrombocytosis and shares some phenotypic features with myeloproliferative neoplasm, a hematologic malignancy associated with a somatically acquired JAK2(V617F) mutation. We established a mou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788cb662881d9be9aac3e4f55473c95a
https://escholarship.org/uc/item/1mw4j1t9
https://escholarship.org/uc/item/1mw4j1t9