Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Heung Sun Kwon"'
Autor:
Bill X. Huang, Huazhen Chen, Yuyoung Joo, Heung-Sun Kwon, Cheng Fu, Arthur A. Spector, Hee-Yong Kim
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106550- (2023)
Summary: Activation of adhesion receptor GPR110 by the endogenous ligand synaptamide promotes neurogenesis, neurite growth, and synaptogenesis in developing brains through cAMP signal transduction. However, interacting partners of GPR110 and their in
Externí odkaz:
https://doaj.org/article/9d4d3a392f384e638f1a38fee39cb2bc
Autor:
Heung-Sun Kwon, Karl Kevala, Haohua Qian, Mones Abu-Asab, Samarjit Patnaik, Juan Marugan, Hee-Yong Kim
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5340
It is extremely difficult to achieve functional recovery after axonal injury in the adult central nervous system. The activation of G-protein coupled receptor 110 (GPR110, ADGRF1) has been shown to stimulate neurite extension in developing neurons an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441c9d6defa6d88376ccb5e6d080d2b9
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 7
International Journal of Molecular Sciences, Vol 22, Iss 3386, p 3386 (2021)
Volume 22
Issue 7
International Journal of Molecular Sciences, Vol 22, Iss 3386, p 3386 (2021)
Recovery from axonal injury is extremely difficult, especially for adult neurons. Here, we demonstrate that the activation of G-protein coupled receptor 110 (GPR110, ADGRF1) is a mechanism to stimulate axon growth after injury. N-docosahexaenoylethan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff42b7db32329d91ef47c7fd34282ba
http://europepmc.org/articles/PMC8037074
http://europepmc.org/articles/PMC8037074
Autor:
Juan J. Marugan, Jiwon Lee, Hee-Yong Kim, Heung Sun Kwon, Cheng Fu, Noel Southall, Xin Hu, Bill X. Huang
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
Communications Biology
Communications Biology
Adhesion G protein-coupled receptors (aGPCR) are characterized by a large extracellular region containing a conserved GPCR-autoproteolysis-inducing (GAIN) domain. Despite their relevance to several disease conditions, we do not understand the molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0879a5e0afc98196ae9869acd459c67d
https://doi.org/10.1038/s42003-020-0831-6
https://doi.org/10.1038/s42003-020-0831-6
Publikováno v:
The Journal of Neuroscience. 34:5539-5551
Myocilin is a secreted glycoprotein that belongs to a family of olfactomedin domain-containing proteins. Although myocilin is detected in several ocular and nonocular tissues, the only reported human pathology related to mutations in theMYOCILINgene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9b9c75cede279dc70df4cacd5bd2ab
https://doi.org/10.1523/jneurosci.4731-13.2014
https://doi.org/10.1523/jneurosci.4731-13.2014
Publikováno v:
Journal of Biological Chemistry. 289:10155-10167
Myocilin, a causative gene for open angle glaucoma, encodes a secreted glycoprotein with poorly understood functions. To gain insight into its functions, we produced a stably transfected HEK293 cell line expressing myocilin under an inducible promote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f307838bee596c8de3258230fb4136
https://doi.org/10.1074/jbc.m113.547091
https://doi.org/10.1074/jbc.m113.547091
Autor:
Myung Kuk Joe, Chi-Chao Chan, Jun Zhang, Heung Sun Kwon, Thomas V. Johnson, Stanislav I. Tomarev, Mones Abu-Asab
Publikováno v:
Journal of Biological Chemistry. 288:26357-26371
The glaucoma-associated gene, myocilin, is expressed in ocular and non-ocular tissues including the peripheral nervous system, but its functions in these tissues remain poorly understood. We demonstrate that in sciatic nerve, myocilin is expressed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4b5a6fd696666ceb6a82d2600ecb1a
https://doi.org/10.1074/jbc.m112.446138
https://doi.org/10.1074/jbc.m112.446138
Publikováno v:
Journal of Biological Chemistry. 288:16882-16894
Myocilin is a secreted glycoprotein that is expressed in ocular and non-ocular tissues. Mutations in the MYOCILIN gene may lead to juvenile- and adult-onset primary open-angle glaucoma. Here we report that myocilin is expressed in bone marrow-derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4bada9347ef26005a192d75484fce2
https://doi.org/10.1074/jbc.m112.422972
https://doi.org/10.1074/jbc.m112.422972
Autor:
Juan J. Marugan, Samarjit Patnaik, Jiwon Lee, Hee Yong Kim, Giorgi Kharebava, Bill X. Huang, Mohammad Abdur Rashid, Abhishek Desai, Heung Sun Kwon
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Docosahexaenoic acid (DHA, 22:6n-3) is an omega-3 fatty acid essential for proper brain development. N-docosahexaenoylethanolamine (synaptamide), an endogenous metabolite of DHA, potently promotes neurogenesis, neuritogenesis and synaptogenesis; howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03260c96ec1df84aaeaa707f3381a18f
http://europepmc.org/articles/PMC5075789
http://europepmc.org/articles/PMC5075789
Autor:
Dori L. Borjesson, Heung Sun Kwon, Joshua T. Morgan, Paul Russell, Joshua A. Wood, Stanislav I. Tomarev, Christopher J. Murphy
Adipose-derived mesenchymal stem cells (ASCs) hold promise for use in cell-based therapies. Their intrinsic anti-inflammatory properties are potentially useful for treatments of inflammatory conditions such as uveitis, while their ability to differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97011af0f82acf418dde56907d748dc5
https://escholarship.org/uc/item/9p82b489
https://escholarship.org/uc/item/9p82b489
