Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Heung Sik Hahm"'
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Automated glycan assembly has proven a powerful method to rapidly synthesize large oligosaccharides, though stereoselective cis-glycosylation remains a challenge. Here, the authors demonstrate a system to selectively incorporate multiple cis-glycosid
Externí odkaz:
https://doaj.org/article/322fc83fe2004ff7aa51b9b5748470ab
Autor:
Markus W. Weishaupt, Stefan Matthies, Mattan Hurevich, Claney L. Pereira, Heung Sik Hahm, Peter H. Seeberger
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 1440-1446 (2016)
Vaccines against S. pneumoniae, one of the most prevalent bacterial infections causing severe disease, rely on isolated capsular polysaccharide (CPS) that are conjugated to proteins. Such isolates contain a heterogeneous oligosaccharide mixture of di
Externí odkaz:
https://doaj.org/article/f704f9aed74241d8b435dbccf62c5091
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 617-621 (2015)
A sialic acid glycosyl phosphate building block was designed and synthesized. This building block was used to prepare α-sialylated oligosaccharides by automated solid-phase synthesis selectively.
Externí odkaz:
https://doaj.org/article/0ac26675dd36457ba756d2b848381434
Autor:
Jeffrey W. Brulet, Emmanuel K. Toroitich, Adam L. Borne, Ku-Lung Hsu, Adam H. Libby, Kun Yuan, Rebecca L. McCloud, Heung Sik Hahm, Anthony M. Ciancone, Timothy B. Ware
Publikováno v:
Nature chemical biology
Covalent probes serve as valuable tools for global investigation of protein function and ligand binding capacity. Despite efforts to expand coverage of residues available for chemical proteomics (e.g. cysteine and lysine), a large fraction of the pro
Publikováno v:
Methods in Molecular Biology ISBN: 9781071613979
Methods in Molecular Biology
Methods in Molecular Biology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::715ca2c2ba1d0e04f9c70d403878e4ed
https://doi.org/10.1007/978-1-0716-1398-6_26
https://doi.org/10.1007/978-1-0716-1398-6_26
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2303
Glycosaminoglycans (GAGs) are important sulfated carbohydrates prevalently found in the extracellular matrix that serve many biological functions. The synthesis of structurally diverse but defined GAGs is extremely challenging as one has to account f
Autor:
Adam H. Libby, Ku-Lung Hsu, Emmanuel K. Toroitich, Anthony M. Ciancone, Skylar M Brodowski, Heung Sik Hahm
Publikováno v:
Chembiochem
Sulfonyl-triazoles have emerged as a new reactive group for covalent modification of tyrosine sites on proteins through sulfur-triazole exchange (SuTEx) chemistry. The extent to which this sulfur electrophile can be tuned for developing ligands with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ccfe0154ab4cdebc465848c6b89eac
https://europepmc.org/articles/PMC8206015/
https://europepmc.org/articles/PMC8206015/
Autor:
Gert von Helden, Sandy Gewinner, Eike Mucha, Mateusz Marianski, Daniel A. Thomas, Ana Isabel González Flórez, Waldemar Hoffmann, Weston B. Struwe, Peter H. Seeberger, Heung Sik Hahm, Wieland Schöllkopf, Kevin Pagel
Publikováno v:
Angewandte Chemie
Die Vielfalt der in Glykanen und ihren Konjugaten vorhandenen stereochemischen Isomere stellt eine Herausforderung für ihre Strukturanalyse dar. Üblicherweise wird Massenspektrometrie (MS) in Kombination mit Flüssigchromatographie oder Ionenmobili
Autor:
Peter H. Seeberger, Xiaoqiang Guo, Jana Mrázková, Franck Fieschi, You Yang, Hidenori Tanaka, Bernd Lepenies, Chakkumkal Anish, Frank Schuhmacher, Michaela Wimmerová, Christoph Rademacher, Daniele Leonori, Heung Sik Hahm, João T. Monteiro, Claney L. Pereira, Anika Reinhardt, Sandip Pasari, Sharavathi Guddehalli Parameswarappa, Mark K. Schlegel, Dan Grünstein, Jeyakumar Kandasamy, Guozhi Xiao, Andreas Geissner, Timo Johannssen, Sebastian Götze, Christopher E. Martin, Michel Thépaut
Publikováno v:
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (6), pp.1958-1967. ⟨10.1073/pnas.1800853116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (6), pp.1958-1967. ⟨10.1073/pnas.1800853116⟩
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (6), pp.1958-1967. ⟨10.1073/pnas.1800853116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (6), pp.1958-1967. ⟨10.1073/pnas.1800853116⟩
International audience; Interactions between glycans and glycan binding proteins are essential for numerous processes in all kingdoms of life. Glycan microarrays are an excellent tool to examine protein-glycan interactions. Here, we present a microbe
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Nature Communications
Nature Communications
Automated glycan assembly (AGA) has advanced from a concept to a commercial technology that rapidly provides access to diverse oligosaccharide chains as long as 30-mers. To date, AGA was mainly employed to incorporate trans-glycosidic linkages, where