Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Heung Kyoung Lee"'
Autor:
Minsung Kim, Suhkneung Pyo, Chung Hyo Kang, Chong Ock Lee, Heung Kyoung Lee, Sang Un Choi, Chi Hoon Park
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198347 (2018)
Gastric cancer is a malignancy that has a high mortality rate. Although progress has been made in the treatment of gastric cancer, many patients experience cancer recurrence and metastasis. Folate receptor 1 (FOLR1) is overexpressed on the cell surfa
Externí odkaz:
https://doaj.org/article/9ea7f921dc354f5faa19662885bab7d9
Autor:
Hyesu Yeom, Raghavendra Achary, Yunha Choi, Chi Hoon Park, Joo‐Youn Lee, Heung Kyoung Lee, Pilho Kim, Sung Yun Cho
Publikováno v:
Bulletin of the Korean Chemical Society. 43:577-584
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cbffe62d035fbb5fd9d1c9403564813
https://doi.org/10.1002/bkcs.12490
https://doi.org/10.1002/bkcs.12490
Autor:
Heung Kyoung Lee, Chung Hyo Kang, Hye Gwang Jeong, Chi Hoon Park, Chang-Soo Yun, Sunjoo Ahn, Sang Un Choi, You Hwa Son
Publikováno v:
Anticancer Research. 40:4929-4935
Background Mutations in the isocitrate dehydrogenase 1 (IDH1) gene are frequently found in various cancer types. IDH1 mutants produce 2-hydroxyglutarate (2-HG), an oncometabolite, from alpha-ketoglutarate (α-KG). This 2-HG plays a key role in tumori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c787f79a41c454d1091c1c9cd2b1bd6
https://doi.org/10.21873/anticanres.14496
https://doi.org/10.21873/anticanres.14496
Publikováno v:
Cancers
Volume 13
Issue 22
Cancers, Vol 13, Iss 5738, p 5738 (2021)
Volume 13
Issue 22
Cancers, Vol 13, Iss 5738, p 5738 (2021)
Simple Summary c-Met is known to be overexpressed in gastric cancers. Here, we developed anti-c-Met CAR T cell and measured its anti-tumor efficacy in vitro and in vivo. Our anti c-Met CAR T cells have shown selective killing of c-Met overexpressed g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2bba053488e77b1703929a0b7fd970
Autor:
Akshay D. Takwale, Eun Yeong Kim, Yerin Jang, Dong Ho Lee, Seulgi Kim, Yuri Choi, Jin Hwan Kim, Da Yeon Lee, Yeongrin Kim, So Myoung Lee, Heung Kyoung Lee, Hye Jin Nam, Joo-Youn Lee, Jin Hwa Cho, Jeong Hee Moon, Ga Seul Lee, Jeong-Hoon Kim, Pilho Kim, Chi Hoon Park, Jong Yeon Hwang
Publikováno v:
Bioorganic Chemistry. 127:105923
Molecular glue degraders, such as lenalidomide and pomalidomide, bind to cereblon (CRBN) E3 ligase and subsequently recruit neosubstrate proteins, Ikaros (IKZF1) and Aiolos (IKZF3), for the ubiquitination-proteasomal degradation process. In this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b544fcef6e14bdce7fea1bd240a14d
https://doi.org/10.1016/j.bioorg.2022.105923
https://doi.org/10.1016/j.bioorg.2022.105923
Autor:
Heung Kyoung Lee, Ara Go, Jong Yeon Hwang, Sung Goo Park, Young Uk Jeon, Jae Du Ha, Sung Yun Cho, Chi Hoon Park, Pilho Kim, Sun Jun Park, Ji-Eun Kim, Jeong Hoon Kim, Seung-Hyun Jo, Byoung Chul Park, Chong-Ock Lee, Sung Ah Kim, Sunhong Kim
Publikováno v:
European Journal of Medicinal Chemistry. 166:65-74
Immunomodulatory drugs (IMiDs) exert anti-myeloma activity by binding to the protein cereblon (CRBN) and subsequently degrading IKZF1/3. Recently, their ability to recruit E3 ubiquitin ligase has been used in the proteolysis targeting chimera (PROTAC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1926b61f0b5589af19191e24dea31c1f
https://doi.org/10.1016/j.ejmech.2019.01.023
https://doi.org/10.1016/j.ejmech.2019.01.023
Autor:
Ji-Eun Kim, Chong Ock Lee, Young Hun Kim, Yeongrin Kim, Kwan-Young Jung, Miyoun Yoo, Chi Hoon Park, Sang Un Choi, Heung Kyoung Lee, Min Sung Kim, Minjin Yoo
Publikováno v:
Oncology Letters
Since bromodomain containing 4 (brd4) has been considered as a prominent cancer target, numerous attempts have been made to develop potent brd4 bromodomain inhibitors. The present study provided a novel chemical scaffold which inhibited brd4 activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68bf0638afe151f704eca3e256f84eb
https://doi.org/10.3892/ol.2021.12734
https://doi.org/10.3892/ol.2021.12734
Autor:
Chong Ock Lee, Akshay. D. Takwale, Jeong Hoon Kim, Seung-Hyun Jo, Hyung-Soo Kim, Sunjoo Ahn, Jae Du Ha, Jong Yeon Hwang, Choong Hoon Shin, Yeong Uk Jeon, Heung Kyoung Lee
Publikováno v:
European journal of medicinal chemistry. 208
Proteolysis-targeting chimera (PROTAC)-mediated protein degradation is a rapidly emerging therapeutic intervention that induces the degradation of targeted proteins. Herein, we report the design and biological evaluation of a series of androgen recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3be12fd913cfdfcdff9d3d08c755cca
https://pubmed.ncbi.nlm.nih.gov/32961381
https://pubmed.ncbi.nlm.nih.gov/32961381
Autor:
Chong Ock Lee, Sung Woong Moon, Heung Kyoung Lee, Chul Woong Chung, Sang Un Choi, Minjin Yoo, Young Hun Kim, Minsung Kim, Miyoun Yoo, Hye Kyung Chang, Chi Hoon Park, Ji-Eun Kim, Suhkneung Pyo, Kwan-Young Jung, Jung-Nyoung Heo, Chang-Soo Yun
Publikováno v:
Biochemical and Biophysical Research Communications. 503:882-887
Bromodomain-containing protein 4 (Brd4) is known to play a key role in tumorigenesis. It binds acetylated histones to regulate the expression of numerous genes. Because of the importance of brd4 in tumorigenesis, much research has been undertaken to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36e94d2e06ef81c94be197122569424
https://doi.org/10.1016/j.bbrc.2018.06.091
https://doi.org/10.1016/j.bbrc.2018.06.091
Autor:
Chong Ock Lee, Heung Kyoung Lee, Minsung Kim, Sang Un Choi, Chi Hoon Park, Chung Hyo Kang, Suhkneung Pyo
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 6, p e0198347 (2018)
PLoS ONE, Vol 13, Iss 6, p e0198347 (2018)
Gastric cancer is a malignancy that has a high mortality rate. Although progress has been made in the treatment of gastric cancer, many patients experience cancer recurrence and metastasis. Folate receptor 1 (FOLR1) is overexpressed on the cell surfa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2719d65fc0eeb8afd451ef1b5f2aac6e
http://europepmc.org/articles/PMC5991383
http://europepmc.org/articles/PMC5991383