Microglia depletion leads to increased susceptibility to ocular hypertension-dependent glaucoma.

Autor: Diemler CA; The Jackson Laboratory, Bar Harbor, ME, United States.; Graduate School of Biological Sciences and Engineering, University of Maine, Orono, ME, United States., MacLean M; The Jackson Laboratory, Bar Harbor, ME, United States., Heuer SE; The Jackson Laboratory, Bar Harbor, ME, United States.; Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA, United States., Hewes AA; The Jackson Laboratory, Bar Harbor, ME, United States., Marola OJ; The Jackson Laboratory, Bar Harbor, ME, United States., Libby RT; Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY, United States., Howell GR; The Jackson Laboratory, Bar Harbor, ME, United States.; Graduate School of Biological Sciences and Engineering, University of Maine, Orono, ME, United States.; Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY, United States.

Publikováno v: Frontiers in aging neuroscience [Front Aging Neurosci] 2024 Jul 02; Vol. 16, pp. 1396443. Date of Electronic Publication: 2024 Jul 02 (Print Publication: 2024).

Transcriptome analysis reveals organ-specific effects of 2-deoxyglucose treatment in healthy mice.

Autor: Wells AE; The Jackson Laboratory, Bar Harbor, ME, United States of America., Wilson JJ; The Jackson Laboratory, Bar Harbor, ME, United States of America., Heuer SE; The Jackson Laboratory, Bar Harbor, ME, United States of America.; Tufts University Graduate School of Biomedical Sciences, Boston, MA, United States of America., Sears JD; The Jackson Laboratory, Bar Harbor, ME, United States of America., Wei J; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China., Pandey R; The Jackson Laboratory, Bar Harbor, ME, United States of America., Costa MW; The Jackson Laboratory, Bar Harbor, ME, United States of America., Kaczorowski CC; The Jackson Laboratory, Bar Harbor, ME, United States of America.; Tufts University Graduate School of Biomedical Sciences, Boston, MA, United States of America.; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, United States of America., Roopenian DC; The Jackson Laboratory, Bar Harbor, ME, United States of America., Chang CH; The Jackson Laboratory, Bar Harbor, ME, United States of America.; Tufts University Graduate School of Biomedical Sciences, Boston, MA, United States of America.; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, United States of America., Carter GW; The Jackson Laboratory, Bar Harbor, ME, United States of America.; Tufts University Graduate School of Biomedical Sciences, Boston, MA, United States of America.; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, United States of America.

Publikováno v: PloS one [PLoS One] 2024 Mar 07; Vol. 19 (3), pp. e0299595. Date of Electronic Publication: 2024 Mar 07 (Print Publication: 2024).

Control of hippocampal synaptic plasticity by microglia-dendrite interactions depends on genetic context in mouse models of Alzheimer's disease.

Autor: Heuer SE; The Jackson Laboratory, Bar Harbor, Maine, USA.; Graduate School of Biomedical Sciences, Tufts University, Boston, Massachusetts, USA., Keezer KJ; The Jackson Laboratory, Bar Harbor, Maine, USA., Hewes AA; The Jackson Laboratory, Bar Harbor, Maine, USA., Onos KD; The Jackson Laboratory, Bar Harbor, Maine, USA., Graham KC; The Jackson Laboratory, Bar Harbor, Maine, USA., Howell GR; The Jackson Laboratory, Bar Harbor, Maine, USA.; Graduate School of Biomedical Sciences, Tufts University, Boston, Massachusetts, USA.; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, Maine, USA., Bloss EB; The Jackson Laboratory, Bar Harbor, Maine, USA.; Graduate School of Biomedical Sciences, Tufts University, Boston, Massachusetts, USA.; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, Maine, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Jan; Vol. 20 (1), pp. 601-614. Date of Electronic Publication: 2023 Sep 27.

Genetic context controls early microglia-synaptic interactions in mouse models of Alzheimer's disease.

Autor: Heuer SE; The Jackson Laboratory, Bar Harbor, ME 04609, USA.; Tufts University Graduate School of Biomedical Sciences, Boston, MA 02111, USA., Keezer KJ; The Jackson Laboratory, Bar Harbor, ME 04609, USA., Hewes AA; The Jackson Laboratory, Bar Harbor, ME 04609, USA., Onos KD; The Jackson Laboratory, Bar Harbor, ME 04609, USA., Graham KC; The Jackson Laboratory, Bar Harbor, ME 04609, USA., Howell GR; The Jackson Laboratory, Bar Harbor, ME 04609, USA.; Tufts University Graduate School of Biomedical Sciences, Boston, MA 02111, USA.; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, Maine 04469, USA., Bloss EB; The Jackson Laboratory, Bar Harbor, ME 04609, USA.; Tufts University Graduate School of Biomedical Sciences, Boston, MA 02111, USA.; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, Maine 04469, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Apr 29. Date of Electronic Publication: 2023 Apr 29.

Nucleic Acid-Sensing and Interferon-Inducible Pathways Show Differential Methylation in MZ Twins Discordant for Lupus and Overexpression in Independent Lupus Samples: Implications for Pathogenic Mechanism and Drug Targeting.

Autor: Marion MC; Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.; Center for Precision Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA., Ramos PS; Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA., Bachali P; AMPEL BioSolutions, LLC and RILITE Research Institute, Charlottesville, VA 22902, USA., Labonte AC; AMPEL BioSolutions, LLC and RILITE Research Institute, Charlottesville, VA 22902, USA., Zimmerman KD; Center for Precision Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA., Ainsworth HC; Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.; Center for Precision Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA., Heuer SE; AMPEL BioSolutions, LLC and RILITE Research Institute, Charlottesville, VA 22902, USA.; The Jackson Laboratory, Tufts Graduate School of Biomedical Sciences, Bar Harbor, ME 04609, USA., Robl RD; AMPEL BioSolutions, LLC and RILITE Research Institute, Charlottesville, VA 22902, USA., Catalina MD; AMPEL BioSolutions, LLC and RILITE Research Institute, Charlottesville, VA 22902, USA., Kelly JA; Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA., Howard TD; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA., Lipsky PE; AMPEL BioSolutions, LLC and RILITE Research Institute, Charlottesville, VA 22902, USA., Grammer AC; AMPEL BioSolutions, LLC and RILITE Research Institute, Charlottesville, VA 22902, USA., Langefeld CD; Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.; Center for Precision Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.

Publikováno v: Genes [Genes (Basel)] 2021 Nov 26; Vol. 12 (12). Date of Electronic Publication: 2021 Nov 26.