A key role for peroxynitrite-mediated inhibition of cardiac ERG (Kv11.1) K+ channels in carbon monoxide–induced proarrhythmic early afterdepolarizations

Autor: Al-Owais, MM, Hettiarachchi, NT, Kirton, HM, Hardy, ME, Boyle, JP, Scragg, JL, Steele, DS, Peers, CS

Exposure to carbon monoxide (CO) causes early afterdepolarization arrhythmias. Previous studies in rats indicated arrhythmias arose due to augmentation of the late Na+ current. The purpose of the present study was to examine the basis of CO-induced a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::4d3e52305f766d162861e791ab58bdf8

Multiple mechanisms mediating carbon monoxide inhibition of the voltage-gated K+ channel Kv1.5

Autor: Al-Owais, MM, Hettiarachchi, NT, Boyle, JP, Scragg, JL, Elies, J, Dallas, ML, Lippiat, JD, Steele, DS, Peers, C

Publikováno v: Cell Death & Disease

The voltage-gated K+ channel plays key roles in the vasculature and in atrial excitability, and contributes to apoptosis in various tissues. In this study, we have explored its regulation by carbon monoxide (CO), a product of the cytoprotective heme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e801433ddfa1d4270a77131dbcdbed84
http://europepmc.org/articles/PMC5775415

A homozygous STIM1 mutation impairs store-operated calcium entry and natural killer cell effector function without clinical immunodeficiency

Autor: Parry, DA, Holmes, TD, Gamper, N, El-Sayed, W, Hettiarachchi, NT, Ahmed, M, Cook, GP, Logan, CV, Johnson, CA, Joss, S, Peers, C, Prescott, K, Savic, S, Inglehearn, CF, Mighell, AJ

Publikováno v: The Journal of Allergy and Clinical Immunology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a3afe90204d47d4b7829d3c975463cee
http://europepmc.org/articles/PMC4775071

Hydrogen sulfide regulates hippocampal neuron excitability via S-sulfhydration of Kv2.1.

Autor: Dallas ML; Reading School of Pharmacy, University of Reading, Reading, RG6 6UB, UK. m.dallas@reading.ac.uk., Al-Owais MM; Division of Cardiovascular and Diabetes Research, LIGHT, Faculty of Medicine and Health, University of Leeds, Leeds, LS2 9JT, UK. m.al-owais@leeds.ac.uk.; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK. m.al-owais@leeds.ac.uk., Hettiarachchi NT; Division of Cardiovascular and Diabetes Research, LIGHT, Faculty of Medicine and Health, University of Leeds, Leeds, LS2 9JT, UK., Vandiver MS; Department of Neuroscience, John's Hopkins University School of Medicine, Baltimore, USA., Jarosz-Griffiths HH; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, LS2 9JT, UK., Scragg JL; Division of Cardiovascular and Diabetes Research, LIGHT, Faculty of Medicine and Health, University of Leeds, Leeds, LS2 9JT, UK., Boyle JP; Division of Cardiovascular and Diabetes Research, LIGHT, Faculty of Medicine and Health, University of Leeds, Leeds, LS2 9JT, UK., Steele D; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK., Peers C; Reading School of Pharmacy, University of Reading, Reading, RG6 6UB, UK.

Publikováno v: Scientific reports [Sci Rep] 2021 Apr 14; Vol. 11 (1), pp. 8194. Date of Electronic Publication: 2021 Apr 14.

Multiple mechanisms mediating carbon monoxide inhibition of the voltage-gated K ⁺ channel Kv1.5.

Autor: Al-Owais MM; Division of Cardiovascular and Diabetes Research, LICAMM, Faculty of Medicine and Health, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK., Hettiarachchi NT; Division of Cardiovascular and Diabetes Research, LICAMM, Faculty of Medicine and Health, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK., Boyle JP; Division of Cardiovascular and Diabetes Research, LICAMM, Faculty of Medicine and Health, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK., Scragg JL; Division of Cardiovascular and Diabetes Research, LICAMM, Faculty of Medicine and Health, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK., Elies J; Division of Cardiovascular and Diabetes Research, LICAMM, Faculty of Medicine and Health, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK., Dallas ML; Division of Cardiovascular and Diabetes Research, LICAMM, Faculty of Medicine and Health, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK., Lippiat JD; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK., Steele DS; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK., Peers C; Division of Cardiovascular and Diabetes Research, LICAMM, Faculty of Medicine and Health, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

Publikováno v: Cell death & disease [Cell Death Dis] 2017 Nov 02; Vol. 8 (11), pp. e3163. Date of Electronic Publication: 2017 Nov 02.