Damaging Mutations in AFDN Contribute to Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate.

Autor: Awotoye W; Iowa Institute for Oral Health Research, University of Iowa, Iowa City, IA, USA.; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA., Mossey PA; Department of Orthodontics, University of Dundee, Dundee, UK., Hetmanski JB; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Gowans LJJ; Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Eshete MA; Surgical Department, School Medicine, Addis Ababa University, Addis Ababa, Ethiopia., Adeyemo WL; Department of Oral and Maxillofacial Surgery, University of Lagos, Lagos, Nigeria., Alade A; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA.; Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA., Zeng E; Division of Biostatistics and Computational Biology, College of Dentistry, University of Iowa, Iowa City, IA, USA., Adamson O; Department of Oral and Maxillofacial Surgery, University of Lagos, Lagos, Nigeria., James O; Department of Oral and Maxillofacial Surgery, University of Lagos, Lagos, Nigeria., Fashina A; Department of Oral and Maxillofacial Surgery, University of Lagos, Lagos, Nigeria., Ogunlewe MO; Department of Oral and Maxillofacial Surgery, University of Lagos, Lagos, Nigeria., Naicker T; Department of Pediatrics, University of KwaZulu-Natal, Durban, South Africa., Adeleke C; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA., Busch T; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA., Li M; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA., Petrin A; Iowa Institute for Oral Health Research, University of Iowa, Iowa City, IA, USA., Oladayo A; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA., Kayali S; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA., Olotu J; Department of Anatomy, University of Port Harcourt, Port Harcourt, Rivers state, Nigeria., Sule V; Department of Operative Dentistry, College of Dentistry, University of Iowa, Iowa City, IA, USA., Hassan M; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA., Pape J; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA., Aladenika ET; Iowa Institute for Oral Health Research, University of Iowa, Iowa City, IA, USA.; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA., Donkor P; Department of Surgery, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Arthur FKN; Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Obiri-Yeboah S; Department of Maxillofacial Sciences, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Sabbah DK; Department of Child Oral Health and Orthodontics, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Agbenorku P; Department of Surgery, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Ray D; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Plange-Rhule G; Department of Child Health, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Oti AA; Department of Maxillofacial Sciences, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Albokhari D; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA., Sobreira N; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA., Dunnwald M; Department of Anatomy and Cell Biology, University of Iowà, Iowa City, IA, USA., Beaty TH; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Taub M; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Marazita ML; Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, and Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Adeyemo AA; National Human Genomic Research Institute, Bethesda, MD, USA., Murray JC; Department of Pediatrics, University of Iowa, Iowa City, IA, USA., Butali A; Iowa Institute for Oral Health Research, University of Iowa, Iowa City, IA, USA.; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA.

Publikováno v: The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association [Cleft Palate Craniofac J] 2024 Apr; Vol. 61 (4), pp. 697-705. Date of Electronic Publication: 2022 Nov 16.

Whole-genome sequencing reveals de-novo mutations associated with nonsyndromic cleft lip/palate.

Autor: Awotoye W; Iowa Institute for Oral Health Research, University of Iowa, Iowa City, IA, USA. awotoye@uiowa.edu.; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA. awotoye@uiowa.edu., Mossey PA; Department of Orthodontics, University of Dundee, Dundee, UK., Hetmanski JB; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Gowans LJJ; Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Eshete MA; Surgical Department, School Medicine, Addis Ababa University, Addis Ababa, Ethiopia., Adeyemo WL; Department of Oral and Maxillofacial Surgery, University of Lagos, Lagos, Nigeria., Alade A; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA.; Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA., Zeng E; Division of Biostatistics and Computational Biology, College of Dentistry, University of Iowa, Iowa City, IA, USA., Adamson O; Department of Oral and Maxillofacial Surgery, University of Lagos, Lagos, Nigeria., Naicker T; Department of Pediatrics, University of KwaZulu-Natal, Durban, South Africa., Anand D; Department of Biological Sciences, University of Delaware, Newark, USA., Adeleke C; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA., Busch T; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA., Li M; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA., Petrin A; Iowa Institute for Oral Health Research, University of Iowa, Iowa City, IA, USA.; Department of Orthodontics, University of Iowa, Iowa City, IA, USA., Aregbesola BS; Department of Oral and Maxillofacial Surgery, Obafemi Awolowo University, Ile-Ife, Osun, A234, Nigeria., Braimah RO; Department of Oral and Maxillofacial Surgery, Obafemi Awolowo University, Ile-Ife, Osun, A234, Nigeria., Oginni FO; Department of Oral and Maxillofacial Surgery, Obafemi Awolowo University, Ile-Ife, Osun, A234, Nigeria., Oladele AO; Department of Oral and Maxillofacial Surgery, Obafemi Awolowo University, Ile-Ife, Osun, A234, Nigeria., Oladayo A; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA., Kayali S; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA., Olotu J; Department of Anatomy, University of Port Harcourt, Choba, Nigeria., Hassan M; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA., Pape J; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA., Donkor P; Department of Surgery, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Arthur FKN; Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Obiri-Yeboah S; Department of Maxillofacial Sciences, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Sabbah DK; Department of Child Oral Health and Orthodontics, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Agbenorku P; Department of Surgery, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Plange-Rhule G; Department of Child Health, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Oti AA; Department of Maxillofacial Sciences, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Gogal RA; Center for Biocatalysis and Bioprocessing (CBB), University of Iowa, Iowa City, USA., Beaty TH; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Taub M; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Marazita ML; Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, and Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Schnieders MJ; Center for Biocatalysis and Bioprocessing (CBB), University of Iowa, Iowa City, USA., Lachke SA; Department of Biological Sciences, University of Delaware, Newark, USA.; Center for Bioinformatics and Computational Biology, University of Delaware, Newark, USA., Adeyemo AA; National Human Genomic Research Institute, Bethesda, MD, USA., Murray JC; Department of Pediatrics, University of Iowa, Iowa City, IA, USA., Butali A; Iowa Institute for Oral Health Research, University of Iowa, Iowa City, IA, USA. Azeez-butali@uiowa.edu.; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA. Azeez-butali@uiowa.edu.

Publikováno v: Scientific reports [Sci Rep] 2022 Jul 11; Vol. 12 (1), pp. 11743. Date of Electronic Publication: 2022 Jul 11.

Detecting Gene-Environment Interaction for Maternal Exposures Using Case-Parent Trios Ascertained Through a Case With Non-Syndromic Orofacial Cleft.

Autor: Zhang W; Department of Epidemiology, School of Public Health, Johns Hopkins University, Baltimore, MD, United States., Venkataraghavan S; Department of Epidemiology, School of Public Health, Johns Hopkins University, Baltimore, MD, United States., Hetmanski JB; Department of Epidemiology, School of Public Health, Johns Hopkins University, Baltimore, MD, United States., Leslie EJ; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, United States., Marazita ML; Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine and Clinical and Translational Science, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States., Feingold E; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States., Weinberg SM; Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine and Clinical and Translational Science, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States., Ruczinski I; Department of Biostatistics, School of Public Health, Johns Hopkins University, Baltimore, MD, United States., Taub MA; Department of Biostatistics, School of Public Health, Johns Hopkins University, Baltimore, MD, United States., Scott AF; Department of Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, United States., Ray D; Department of Epidemiology, School of Public Health, Johns Hopkins University, Baltimore, MD, United States., Beaty TH; Department of Epidemiology, School of Public Health, Johns Hopkins University, Baltimore, MD, United States.

Publikováno v: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2021 Apr 16; Vol. 9, pp. 621018. Date of Electronic Publication: 2021 Apr 16 (Print Publication: 2021).

Whole genome sequencing of orofacial cleft trios from the Gabriella Miller Kids First Pediatric Research Consortium identifies a new locus on chromosome 21.

Autor: Mukhopadhyay N; Department of Oral Biology, Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Bridgeside Point Suite 500, 100 Technology Dr., Pittsburgh, PA, 15219, USA., Bishop M; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, 30322, USA., Mortillo M; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA., Chopra P; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, 30322, USA., Hetmanski JB; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, 21205, USA., Taub MA; Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, 21205, USA., Moreno LM; Department of Orthodontics, College of Dentistry, University of Iowa, Iowa City, IA, 52242, USA., Valencia-Ramirez LC; Fundación Clínica Noel (http://www.clinicanoel.org.co/), Medellín, Colombia., Restrepo C; Fundación Clínica Noel (http://www.clinicanoel.org.co/), Medellín, Colombia., Wehby GL; Department of Health Management and Policy, College of Public Health, University of Iowa, Iowa City, IA, 52242, USA., Hecht JT; Department of Pediatrics, McGovern Medical School and School of Dentistry, UT Health at Houston, Houston, TX, 77030, USA., Deleyiannis F; UC Health Plastic and Reconstructive Surgery, Colorado Springs, CO, 80907, USA., Butali A; Iowa Institute of Oral Health Research, College of Dentistry, University of Iowa, Iowa City, IA, 52242, USA., Weinberg SM; Department of Oral Biology, Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Bridgeside Point Suite 500, 100 Technology Dr., Pittsburgh, PA, 15219, USA.; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15219, USA., Beaty TH; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, 21205, USA., Murray JC; Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Leslie EJ; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, 30322, USA., Feingold E; Department of Oral Biology, Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Bridgeside Point Suite 500, 100 Technology Dr., Pittsburgh, PA, 15219, USA.; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15219, USA.; Department of Biostatistics Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Marazita ML; Department of Oral Biology, Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Bridgeside Point Suite 500, 100 Technology Dr., Pittsburgh, PA, 15219, USA. marazita@pitt.edu.; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15219, USA. marazita@pitt.edu.; Department of Psychiatry, School of Medicine and Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, 15260, USA. marazita@pitt.edu.

Publikováno v: Human genetics [Hum Genet] 2020 Feb; Vol. 139 (2), pp. 215-226. Date of Electronic Publication: 2019 Dec 17.

Genetic effects and causal association analyses of 14 common conditions/diseases in multimorbidity patterns.

Autor: Fu, Ting^1,2 (AUTHOR), Yang, Yi-Qun^1,2 (AUTHOR), Tang, Chang-Hua³ (AUTHOR), He, Pei^1,2 (AUTHOR) leisf@suda.edu.cn, Lei, Shu-Feng^1,2,4 (AUTHOR) leisf@suda.edu.cn

Publikováno v: PLoS ONE. 5/16/2024, Vol. 19 Issue 5, p1-15. 15p.