Zobrazeno 1 - 10
of 1 198
pro vyhledávání: '"Heterogeneous ribonucleoprotein particle"'
Autor:
Xiaolin Ma, Huaxi Xu, Jin Ye, Juan Zhang, Qingyang Zhang, Yingjun Zhao, Hongda Liu, Keqiang He, Chao Wang, Ji Yuan, Wei Zhang, Xiaohui Li, Qiang Liu
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-19 (2021)
Molecular Neurodegeneration
Molecular Neurodegeneration
BackgroundAberrant alternative splicing plays critical role in aging and age-related diseases. Heterogeneous nuclear ribonucleoproteins (hnRNPs) reportedly regulate RNA splicing process. Whether and how hnRNPs contribute to age-related neurodegenerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ecf1efc262f6c7d55e912eb07700b18
https://doaj.org/article/653dd67fd7004fd4b10f2c4a1e56cfc2
https://doaj.org/article/653dd67fd7004fd4b10f2c4a1e56cfc2
Autor:
Pietro Fratta, Dipanjan Bhattacharya, Towfique Raj, Sara Cappelli, Jack Humphrey, Anna-Leigh Brown, Tammaryn Lashley, Marco Foiani, Yi Hua Low, Sandrine C. Foti, Yasmine T. Asi, Emanuele Buratti, Ariana Gatt, Alexander Bampton
Publikováno v:
Acta Neuropathologica
Heterogeneous nuclear ribonucleoproteins (HnRNPs) are a group of ubiquitously expressed RNA-binding proteins implicated in the regulation of all aspects of nucleic acid metabolism. HnRNP K is a member of this highly versatile hnRNP family. Pathologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62a478772e8d7759ac52cc744899c9b
http://europepmc.org/articles/PMC8423707
http://europepmc.org/articles/PMC8423707
Autor:
Ming Zhao, Lei Wang, Weidong Liu, Bin Zhu, Caiping Ren, Hecheng Zhu, Wen Xie, Shasha Li, Yao Zhou, Xingjun Jiang, Cong Zhao
Publikováno v:
International Journal of Biological Sciences
The self-renewal, pluripotency and differentiation of stem cells are regulated by various genetic and epigenetic factors. As a kind of RNA binding protein (RBP), the heterogeneous nuclear ribonucleoproteins (hnRNPs) can act as "RNA scaffold" and recr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d61645b7c2cdc45bf921f246461c875
http://europepmc.org/articles/PMC7975692
http://europepmc.org/articles/PMC7975692
Autor:
Katherine M. Coburn, David J. Weber, Santosh Kesari, Gerald M. Wilson, Elmar Nurmemmedov, Wenbo Yu, Alexander D. MacKerell, Elizabeth T. Chang, Eduardo Solano-Gonzalez
Publikováno v:
Nucleic Acids Research
We have identified chemical probes that simultaneously inhibit cancer cell progression and an immune checkpoint. Using the computational Site Identification by Ligand Competitive Saturation (SILCS) technology, structural biology and cell-based assays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f28928812e51cf2d5ded3fcc4f031f
https://doi.org/10.1093/nar/gkaa1254
https://doi.org/10.1093/nar/gkaa1254
Autor:
Zheng Huo, Jiawei Zhou, Guohui Ma, Jintao Fang, Qian Xu, Qinghui Han, Yugang Guo, Yuxin Xing, Mengzhen Wang
Publikováno v:
Aging (Albany NY)
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are RNA-binding proteins that are reported to play a crucial role in the pathogenic process of multiple malignancies. However, their expression patterns, clinical application significance and prognost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d1f91fdfe39e31219cbdb89ea8e608
http://europepmc.org/articles/PMC7906176
http://europepmc.org/articles/PMC7906176
Publikováno v:
Molecular Omics. 17:503-516
RNA-binding proteins (RBPs) have conserved domains and consensus sequences that interact with RNAs and other proteins forming ribonucleoprotein (RNP) complexes. RNPs are involved in the regulation of several cellular processes, including transcriptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81518806acf26eabef9f85a3988b77c5
https://doi.org/10.1039/d1mo00024a
https://doi.org/10.1039/d1mo00024a
Autor:
Liao, Susan E, Regev, Oded
Publikováno v:
Nucleic Acids Research
Phase-separated membraneless bodies play important roles in nucleic acid biology. While current models for the roles of phase separation largely focus on the compartmentalization of constituent proteins, we reason that other properties of phase separ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91969df6f83115c8a5c2b7dae14b377
https://doi.org/10.1093/nar/gkaa1209
https://doi.org/10.1093/nar/gkaa1209
Autor:
Aldo Barrera, Leandro Fernández-García, Jorge Vera-Otarola, Valeria Olguín, Hade Ramos, Marcelo López-Lastra, Andrew J. Mouland, Karla Pino, Jenniffer Angulo
Publikováno v:
Nucleic Acids Research
The full-length mRNAs of the human immunodeficiency virus type-1 (HIV-1), the human T-cell lymphotropic virus type-1 (HTLV-1), and the mouse mammary tumor virus (MMTV) harbor IRESs. The activity of the retroviral-IRESs requires IRES-transacting facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d6a3ef7211d24db6e98e0785a17ab4
https://doi.org/10.1093/nar/gkaa765
https://doi.org/10.1093/nar/gkaa765
Autor:
Xiaolin Guo, Jingwei Liu, Hao Li, Di Dai, Shixuan Shen, Dong Xiaolong, Shitong Cheng, Liping Sun
Publikováno v:
Journal of Cellular and Molecular Medicine
As the most critical alternative splicing regulator, heterogeneous nuclear ribonucleoproteins (hnRNPs) have been reported to be implicated in various aspects of cancer. However, the comprehensive understanding of hnRNPs in cancer is still lacking. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36c54b5f1d0fcf296ef6e69aa93fcfb
http://europepmc.org/articles/PMC7576281
http://europepmc.org/articles/PMC7576281
Publikováno v:
Acta Neuropathologica
Dysregulated RNA metabolism is emerging as a crucially important mechanism underpinning the pathogenesis of frontotemporal dementia (FTD) and the clinically, genetically and pathologically overlapping disorder of amyotrophic lateral sclerosis (ALS).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::987df488829fa8719f02ebe317d95b43
https://doi.org/10.1007/s00401-020-02203-0
https://doi.org/10.1007/s00401-020-02203-0