GC-elements controlling HRAS transcription form i-motif structures unfolded by heterogeneous ribonucleoprotein particle A1

Autor: Susanna Cogoi, Luigi E. Xodo, Giulia Miglietta, Erik B. Pedersen

Publikováno v: Miglietta, G, Cogoi, S, Pedersen, E B & Xodo, L E 2015, ' GC-elements controlling HRAS transcription form i-motif structures unfolded by heterogeneous ribonucleoprotein particle A1 ', Scientific Reports, vol. 5, 18097 . https://doi.org/10.1038/srep18097
Scientific Reports

HRAS is regulated by two neighbouring quadruplex-forming GC-elements (hras-1 and hras-2), located upstream of the major transcription start sites (doi: 10.1093/nar/gku 5784). In this study we demonstrate that the C-rich strands of hras-1 and hras-2 f

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https://findresearcher.sdu.dk:8443/ws/files/129761581/GC_elements_controlling_HRAS_transcription_form_i_motif_structures_unfolded_by_heterogeneous_ribonucleoprotein_particle_A1.pdf

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Specific binding of heterogeneous ribonucleoprotein particle protein K to the human c-myc promoter, in vitro

Autor: Masato Takimoto, Henry C. Krutzsch, Mark I. Avigan, Takeshi Tomonaga, Gideon Dreyfuss, David Levens, Michael J. Matunis

Publikováno v: Scopus-Elsevier

A homopurine/homopyrimidine-like sequence is found 100-150 base pairs upstream of the human c-myc promoter P1. This element, termed the CT-element, has been shown to augment expression from P1, and it serves as a positive transcriptional element when

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7199966c06ecc62b377fb1021e4b6c8
http://www.scopus.com/inward/record.url?eid=2-s2.0-0027182876&partnerID=MN8TOARS

HnRNP K mislocalisation is a novel protein pathology of frontotemporal lobar degeneration and ageing and leads to cryptic splicing

Autor: Pietro Fratta, Dipanjan Bhattacharya, Towfique Raj, Sara Cappelli, Jack Humphrey, Anna-Leigh Brown, Tammaryn Lashley, Marco Foiani, Yi Hua Low, Sandrine C. Foti, Yasmine T. Asi, Emanuele Buratti, Ariana Gatt, Alexander Bampton

Publikováno v: Acta Neuropathologica

Heterogeneous nuclear ribonucleoproteins (HnRNPs) are a group of ubiquitously expressed RNA-binding proteins implicated in the regulation of all aspects of nucleic acid metabolism. HnRNP K is a member of this highly versatile hnRNP family. Pathologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62a478772e8d7759ac52cc744899c9b
http://europepmc.org/articles/PMC8423707

Small molecules inhibitors of the heterogeneous ribonuclear protein A18 (hnRNP A18): a regulator of protein translation and an immune checkpoint

Autor: Katherine M. Coburn, David J. Weber, Santosh Kesari, Gerald M. Wilson, Elmar Nurmemmedov, Wenbo Yu, Alexander D. MacKerell, Elizabeth T. Chang, Eduardo Solano-Gonzalez

Publikováno v: Nucleic Acids Research

We have identified chemical probes that simultaneously inhibit cancer cell progression and an immune checkpoint. Using the computational Site Identification by Ligand Competitive Saturation (SILCS) technology, structural biology and cell-based assays

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f28928812e51cf2d5ded3fcc4f031f
https://doi.org/10.1093/nar/gkaa1254